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Compositions of an anticonvulsant and mirtazapine to prevent weight gain

a technology of mirtazapine and anticonvulsant, which is applied in the field of compositions and methods of pharmaceutical products, can solve the problems of obesity being generally considered a psychological problem, emerging as a global problem, and death of users, and achieves the effect of increasing the efficacy of mirtazapine and preventing weight gain

Inactive Publication Date: 2010-07-15
DUKE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]Disclosed are pharmaceutical compositions comprising mirtazapine and an anticonvulsant drug. Also disclosed are methods of preventing weight gain associated with the administration of mirtazapine comprising identifying a patient to whom mirtazapine is to be administered and administering to said patient a pharmaceutical composition comprising mirtazapine and an anticonvulsant drug. Further disclosed are methods of increasing the efficacy of mirtazapine comprising identifying a patient to whom mirtazapine is to be administered and administering to said patient a pharmaceutical composition comprising mirtazapine and an anticonvulsant drug.

Problems solved by technology

Obesity has been recognized as one of the leading causes of disease and is emerging as a global problem.
Prior to 1994, obesity was generally considered a psychological problem.
Unfortunately, it was discovered that fenfluramine caused heart-valve complications, which in some cases resulted in the death of the user.
There has been some limited success with other combination therapy approaches, particularly in the field of psychological eating disorders.
Of course, this disorder is an issue for only a small portion of the population.
In addition to those individuals who satisfy a strict definition of medical obesity, a significant portion of the adult population is overweight.

Method used

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  • Compositions of an anticonvulsant and mirtazapine to prevent weight gain
  • Compositions of an anticonvulsant and mirtazapine to prevent weight gain

Examples

Experimental program
Comparison scheme
Effect test

example 1

Use of Zonisamide Alone

[0154]Individuals taking an antidepressant, or about to take an antidepressant, who have gained weight as the result of the use of the antidepressant, or are susceptible to gain weight as the result of the use of the antidepressant, are identified. Each individual is instructed to take one 25 mg tablet of zonisamide on a daily basis, in addition to the antidepressant therapy.

[0155]The individuals are monitored for a period of months. It is recommended that the dosage be adjusted so that each individual loses weight at a rate of 10% of initial weight every 6 months. However, the rate of weigh loss for each individual may be adjusted by the treating physician based on the individual's particular needs.

[0156]The dosage of zonisamide can be from about 25 mg to about 800 mg per day, generally given once per day or divided (e.g., equally) into multiple doses. Preferably, the dose is from about 100 mg to about 600 mg per day, more preferably, the dose is from about 2...

example 2

Use of Topiramate Alone

[0157]Individuals taking an antidepressant, or about to take an antidepressant, who have gained weight as the result of the use of the antidepressant, or are susceptible to gain weight as the result of the use of the antidepressant, are identified. Each individual is instructed to take one 25 mg tablet of topiramate on a daily basis, in addition to the antidepressant therapy.

[0158]The individuals are monitored for a period of months. It is recommended that the dosage be adjusted so that each individual loses weight at a rate of 10% of initial weight every 6 months. However, the rate of weigh loss for each individual may be adjusted by the treating physician based on the individual's particular needs.

[0159]The dosage of topiramate can be from about 25 mg to about 1600 mg, preferably from about 50 mg to about 600 mg, more preferably from about 100 mg to about 400 mg. However, it may be necessary to use dosages outside these ranges.

example 3

Combination of Zonisamide and Mirtazapine

[0160]Individuals having a BMI of greater than 25 are identified. Each individual is instructed to take one tablet of zonisamide on a daily basis, in addition to one tablet of mirtazapine on a daily basis. Initially, the drugs are administered as follows: 8 mg mirtazapine and 64 mg zonisamide; or 16 mg mirtazapine and 128 mg zonisamide; or 32 mg mirtazapine and 252 mg zonisamide; generally with an mirtazapine / zonisamide ratio of 1:8.

[0161]The individuals are monitored for a period of months. It is recommended that the dosage be adjusted so that each individual loses weight at a rate of 10% of initial weight every 6 months. However, the rate of weigh loss for each individual may be adjusted by the treating physician based on the individual's particular needs.

[0162]If the initial dosages are not effective, they can be increased.

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Abstract

Disclosed are pharmaceutical compositions comprising mirtazapine and an anticonvulsant drug. Also disclosed are methods of preventing weight gain associated with the administration of mirtazapine comprising identifying a patient to whom mirtazapine is to be administered and administering to said patient a pharmaceutical composition comprising mirtazapine and an anticonvulsant drug. Further disclosed are methods of increasing the efficacy of mirtazapine comprising identifying a patient to whom mirtazapine is to be administered and administering to said patient a pharmaceutical composition comprising mirtazapine and an anticonvulsant drug.

Description

RELATED APPLICATIONS[0001]The present application is a continuation-in-part of U.S. application Ser. No. 11 / 034,316, filed Jan. 11, 2005 by Gadde et al., and entitled “COMPOSITIONS OF AN ANTICONVULSANT AND AN ANTIPSYCHOTIC DRUG AND METHODS OF USING THE SAME FOR AFFECTING WEIGHT LOSS,” which in turn claims priority to U.S. Provisional Patent Application Ser. No. 60 / 616,393, filed Oct. 5, 2004 by Gadde et al., and entitled “COMPOSITIONS OF AN ANTICONVULSANT AND AN ANTIPSYCHOTIC DRUG AND METHODS OF USING THE SAME FOR AFFECTING WEIGHT LOSS,” U.S. Provisional Patent Application Ser. No. 60 / 567,896, filed May 3, 2004 by Ranga Krishnan, and entitled “COMPOSITIONS FOR AFFECTING WEIGHT LOSS,” and U.S. Provisional Patent Application Ser. No. 60 / 535,799, filed Jan. 13, 2004 by Gadde et al., and entitled “METHOD FOR REDUCING WEIGHT GAIN RISK ASSOCIATED WITH ANTIDEPRESSANT THERAPY,” all of which are incorporated herein by reference in their entirety.BACKGROUND OF THE INVENTION[0002]1. Field of t...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/55A61P3/04
CPCA61K31/137A61K31/155A61K45/06A61K33/00A61K31/7008A61K31/551A61K31/19A61K31/352A61K31/42A61K31/423A61K31/425A61K31/435A61K31/55A61K2300/00A61P3/04
Inventor KRISHNAN, K. RANGA R.GADDE, KISHORE M.
Owner DUKE UNIV
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