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Ophthalmic composition

a technology of ophthalmic composition and composition, applied in the field of ophthalmic composition, can solve the problems of eye strain, eye dryness for contact lens users, inhomogeneity, etc., and achieve the effects of reducing eye stress, suppressing eye dryness, and effectively reducing eye strain

Inactive Publication Date: 2010-09-23
ROHTO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0030]The wetting solution—eye drops for contact lenses of the present invention can efficiently stabilize the tear film during wearing contact lens, and can suppress eye dryness, eye strain, or contrast sensitivity decrease effectively.
[0031]The wetting solution—eye drops for contact lenses of the present invention also have an effect of reducing a stress on eyes caused by contact lens wearing. It is thought that eye dryness or eye strain during wearing contact lens is also related to the stress to corneal cells, and thus an effect of improving eye dryness or reducing eye strain by the wetting solution—eye drops for contact lenses of the present invention is accompanied with an effect of reducing the stress caused by wearing contact lens.
[0032]In addition, the wetting solution—eye drops for contact lenses of the present invention imparts a favorable sensation in using and it is not necessary to have a contact lens wetting solution and eye drops separately any more, and thus the solution is highly convenient and portable with no risk of misuse and it is safe as well.
[0033]Further, the wetting solution—eye drops for contact lenses of the present invention has an advantages including cost reduction in manufacturing stage, efficiency of transportation and display in distribution stage, such as reduction of transportation cost, and increase of safety in handling products in sales stage. Accordingly, the wetting solution—eye drops for contact lenses of the present invention can also contribute to the reduction of energy consumption, and is thus useful for energy saving, which means it can reduce the damage to the environment.
[0034]As described above, the present invention provides a wetting solution—eyedrops, which exerts advantageous effects on achieving suppression of eye dryness, reduction of eye strain and improvement of contrast sensitivity during wearing contact lens, and is safe and convenient, and which can make it possible to secure safety and improve efficiency in the course from manufacturing to sales. Therefore the present invention can simultaneously achieve improvements of convenience and safety for the contact lens users, and efficiencies in each stage from manufacturing, transportation to sales.

Problems solved by technology

Wearing contact lens, however, places a load on eye though it varies between individuals.
The typical complaint from contact lens users is eye dryness.
In particular, the lipid layer in the nearest position to the external environment prevents evaporation of tear fluid, however, due to the cause such as thinning or destabilization of tear film, the lipid layer is also prone to become thin, inhomogeneous, or unstable, and evaporation of tear fluid is promoted, and thus dry eye symptom including eye desiccation is occurred.
And such destruction (destabilization) of tear film causes spots wherein the lipid layer is extremely thin or not existed.
It has also been known that even if a person has healthy eyes without lenses, when he wears contact lenses the tear film becomes inhomogeneous and he easily feels desiccation of the eyes, thus he is susceptible to dry eye.
A method of applying artificial tears was conventionally taken to treat eye dryness, however, the method of only using artificial tears could not achieve stabilization of tear film, and thus a sufficient effect could not be obtained.
However, the systems and the compositions described in these documents have not sufficiently exerted an effect of stabilizing tear film, particularly lipid layer continuously and effectively.
Further, other problems associated with wearing contact lens include decreased contrast sensitivity.
Decreased contrast sensitivity may lead, for example, to an accident because it is difficult for a person to distinguish the contrast between the road surface and obstacles while walking, or to an inconvenience in sports (especially, ball game) because it is difficult for a person to perceive the contrast between ball and background.
As a solution to these problems, there is an attempt to change the contact lens itself, however, it has not been known that contrast sensitivity can be improved by an ophthalmic composition.
These solutions, however, are often similar in appearance because of the dosage and so on, despite of the difference in the purpose of use (application), therefore, there was a risk of misuse.
For seller, there also was a risk of inducing misuses by consumers due to false recognition at providing information or mix-ups of products.

Method used

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  • Ophthalmic composition

Examples

Experimental program
Comparison scheme
Effect test

examples

[0105]The present invention is illustrated in more detail by Test Examples and Examples, but should not be construed to be limited thereto.

[0106]In Test Examples, the tests were conducted as successively as possible to keep the measuring condition, in particular the subject's condition almost constant. Each Test Example was carried out independently.

[0107]The viscosities in each Example and Comparative Example were determined by using TVE-20L cone-plate type viscometer (manufactured by TOKIMEC Inc. and supplied by TOKI SANGYO, Co., Ltd., Japan), which is a kind of E-type viscometer, under the following measuring condition according to the manufacturer's instructions. Unless stated otherwise, the measurement was carried out according to the viscometric determination described in JPA 2006-348055. The measuring condition used was as follows.

Measuring Condition:

[0108]Rotational frequency: 100 rpm (the viscosity is measured at the highest rotational frequency among the measurable rotatio...

examples 7 to 11

[0144]The wetting solution—eyedrops for contact lenses (Examples 7 to 11) were prepared according to the formulations described in Table 18. The unit for each ingredient to be compounded in Table 18 is g / 100 mL. All these Examples showed similar effects of the invention as Example 1 in the above Tests 1 to 4.

TABLE 18Ex. 7Ex. 8Ex. 9Ex. 10Ex. 11HPMC1)———0.20.2Hydroxyethylcellulose2)0.20.6———Polyvinyl alcohol————1(partially saponifiedproduct)Dextran 70——0.1——Macrogol 4000———1—1-Menthol0.010.010.005—0.015d-Camphor——0.001—0.01Peppermint oil———0.002—Geraniol——0.005——Mint oil———0.002—Bergamot oil————0.002Polysorbate 800.1———0.3POE hydrogenated castor—0.050.050.3—oil 60Poloxamer 407————0.1Sodium chloride0.440.220.440.440.44Potassium chloride0.080.080.080.080.08Boric acid1111—Borax0.20.20.20.2—Sodium dihydrogen————0.25phosphateDisodium hydrogen————0.05phosphateEdetate sodium0.050.050.050.050.05Polyhexanide————0.0001hydrochloridePurified waterq.s.q.s.q.s.q.s.q.s.Total volume100mL100mL100mL100...

formulation example 1 to 10

[0152]The wetting solution—eye drops for contact lenses (Formulation Example 1 to 10) were prepared according to the prescriptions described in Table 20. The unit for each ingredient to be compounded in Table 20 is g / 100 mL.

TABLE 20Form. 1Form. 2Form. 3Form. 4Form. 5HPMC1)0.010.2———Hydroxyethylcellulose2)——0.050.40.01Polyvinyl alcohol——2——(partially saponifiedproduct)Polyvinylpyrrolidone2.5——1.5—K90Carboxy vinyl polymer—0.2——0.21-Menthol0.010.0050.0150.004—d-Camphor0.0080.0050.010——Peppermint oil———0.005—Geraniol————0.005Bergamot oil————0.002Polysorbate 800.05———0.1POE hydrogenated castor0.050.50.10.2—oil 60Potassium magnesium—1———aspartateEpsilon-aminocaproic———2—acidSodium chloride0.440.220.440.440.3Potassium chloride0.080.080.080.080.08Boric acid11—1.81Borax0.20.2—0.20.2Disodium hydrogen——0.3——phosphate.12 hydratesSodium dihydrogen——0.02——phosphate.2hydratesEdetate sodium0.050.050.050.010.2Polyhexanide—0.0001———hydrochloridePotassium sorbate——0.1——Purified waterq.s.q.s.q.s.q.s.q....

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Abstract

The present invention provides an ophthalmic composition which stabilizes the tear film during wearing contact lens, prevents eye dryness, imparts a favorable sensation in using, is highly convenient with no risk of misuse and shows a high efficiency in the course from manufacturing to sales. More specifically, the present invention provides a wetting solution—eye drops for contact lenses comprising (A) one or more member (s) selected from the group consisting of a cellulose-based polymer, a vinyl-based polymer, polyethylene glycol and dextran; and (B) a terpenoid.

Description

TECHNICAL FIELD[0001]The present invention relates to an ophthalmic composition for alleviating the influence of contact lens on eyes, more specifically to a wetting solution—eye drops for contact lenses, which is excellent, for example, in stabilization of tear film, particularly lipid layer, suppression of sensation of dryness and prevention of decline in visual function during wearing contact lens.BACKGROUND ART[0002]Recently, contact lens, particularly soft contact lens (hereinafter also referred to as SCL) have become very widely used for the purpose of vision correction or beauty. Wearing contact lens, however, places a load on eye though it varies between individuals.[0003]The typical complaint from contact lens users is eye dryness. A healthy tear film is a structure of thin layers with about 7 μm thickness, which is composed of three layers: mucin, aqueous and lipid layers from the eyeball side and protects cornea from drying, stimulation by external environment or the like...

Claims

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Application Information

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IPC IPC(8): A61K31/745A61K31/765A61P43/00
CPCA61K9/0046A61K31/045A61K31/125A61F9/0061A61K31/721A61K31/74A61K31/717A61P27/02A61P27/04A61P43/00
Inventor MATSUMURA, YASUKOFUKUSHIMA, KAZUHIRO
Owner ROHTO PHARM CO LTD
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