Methods of diagnosing and treating complications of pregnancy

a technology of hypertension and complications, applied in the field of pregnancy related hypertension disorders, can solve the problems of ineffective monitoring methods, no known cure for pre-eclampsia, and substantial maternal and fetal morbidity and mortality, and achieve the effects of high affinity, and reducing the elevated levels of soluble endoglin
US20110243956A1Inactive Publication Date: 2011-10-06BETH ISRAEL DEACONESS MEDICAL CENT INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BETH ISRAEL DEACONESS MEDICAL CENT INC
Publication Date
2011-10-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed herein are methods for diagnosing a pregnancy related hypertensive disorder or a predisposition to a pregnancy related hypertensive disorder by measuring the level or biological activity of soluble endoglin. Also disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using compounds that alter soluble endoglin levels or biological activity.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of U.S. patent application Ser. No. 11 / 235,577, filed Sep. 26, 2005, which claims the benefit of the filing date of U.S. provisional application No. 60 / 613,170, filed Sep. 24, 2004, both of which are herein incorporated by reference.STATEMENT AS TO FEDERALLY SPONSORED RESEARCH

[0002] This invention was made in part with support from the Government through NIH Grant Nos. DK 064255 and HL 079594. The Government has certain rights in the invention.FIELD OF THE INVENTION

[0003] In general, this invention relates to the detection and treatment of subjects having a pregnancy related hypertensive disorder.BACKGROUND OF THE INVENTION

[0004] Pre-eclampsia is a syndrome of hypertension, edema, and proteinuria that affects 5 to 10% of pregnancies and results in substantial maternal and fetal morbidity and mortality. Pre-eclampsia accounts for at least 200,000 maternal deaths worldwide per year. The symptoms of pre-eclamp...

Claims

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