Local topical administration formulations containing fipronil

Abstract

The present invention provides formulations and methods useful in eradicating ectoparasites on a domestic animal, decreasing the number of ectoparasites on a domestic animal, and / or preventing ectoparasite infestation on a domestic animal, using a local topical formulation comprising fiproniland a veterinarily acceptable carrier.

Description

BACKGROUND OF THE INVENTION[0001]Animals are often susceptible to infestations by ectoparasites (e.g. flies, ticks, mites and lice), and infections by endoparasites (e.g. filariae and intestinal roundworms). Domesticated animals, such as cats and dogs, are often infested with one or more of the following ectoparasites: cat and dog fleas (Ctenocephalides felis, Ctenocephalides canis, and the like), ticks (Rhipicephalus spp., Ixodes spp., Dermacentor spp., Amblyoma spp. and the like), and mites (Demodex spp., Sarcoptes scabei., Otodectes cynotis. and the like).[0002]Fleas are a particular problem because not only do they adversely affect the health of the animal or human, but they also cause a great deal of psychological stress. Moreover, fleas are also vectors of pathogenic agents in animals, such as dog tapeworm (Dipylidium caninum), including humans.[0003]Similarly, ticks are also harmful to the physical and psychological health of the animal or human. However, the most serious pro...

AI Technical Summary

Benefits of technology

The present invention provides improved fipronil formulations for controlling ectoparasites on domestic animals. These formulations are applied topically and contain fipronil and a veterinary carrier, but do not have any added ingredients to prevent crystallization. The formulations can be applied as needed and are effective in controlling various ectoparasites such as fleas, ticks, flies, or lice on mammals like cats and dogs. The formulations can be applied to a small area of the animal's body and can be used as often as needed.

Problems solved by technology

Animals are often susceptible to infestations by ectoparasites (e.g. flies, ticks, mites and lice), and infections by endoparasites (e.g. filariae and intestinal roundworms).

Fleas are a particular problem because not only do they adversely affect the health of the animal or human, but they also cause a great deal of psychological stress.

Similarly, ticks are also harmful to the physical and psychological health of the animal or human.

However, the most serious problem associated with ticks is that they are the vector of pathogenic agents, agents which cause diseases in both humans and animal.

Occasionally, these toxins are fatal to the host.

Moreover, mites are particularly difficult to combat since there are very few active substances which act on these parasites and they require frequent treatment.

Likewise, farm animals are also susceptible to parasite infestations.

i>. Ticks, such as Boophilus microplus, are particularly difficult to control because they live in the pasture where the farm animals gr

The eradication of ectoparasites within the animal environment is difficult unless the environment is permanently covered in an insecticidal substance, in which case toxicity and reinfestation are problematic.