Il-6 detection based early diagnosis and prediction of systematic inflammatory response syndrome and sepsis in asymptomatic patients

Abstract

Methods, systems and kits for the early diagnosis or prediction of systemic inflammatory response syndrome (SIRS) including sepsis in asymptomatic patients, such as patients undergoing a surgical intervention, are provided. Some embodiments include a method and system for the detection or diagnosis of SIRS, or detection or diagnosis of a risk to suffer from or develop SIRS, in an asymptomatic patient comprising the steps of determining the level of IL-6 (or a variant thereof) in a sample from the patient; comparing the level of IL-6 (or a variant thereof) to a reference level; detecting or diagnosing SIRS or diagnosing a risk to suffer from or develop SIRS, wherein the sample is isolated at least 2 times at short intervals and the determining and comparing steps are both repeated for each sample. Also provided are methods, systems and kits for therapy monitoring and mortality prediction.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of International Application No. PCT / EP2011 / 001006, filed Mar. 2, 2011, which claims the benefit of European Patent Application No. 10002190.6, filed Mar. 2, 2010, the disclosures of which are hereby incorporated by reference in their entirety.BACKGROUND OF THE DISCLOSURE[0002]Systemic inflammatory response (SIRS) and sepsis represent a common and devastating syndrome that is increasing in frequency around the world. SIRS and sepsis are among the most frequent causes of death in intensive care patients.[0003]In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) provided a conceptual and practical framework to define the systemic inflammatory response to infection (American College of Chest Physicians / Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in seps...

AI Technical Summary

Benefits of technology

[0007]According to a first embodiment, it is provided a method for detection or diagnosis of a systemic inflammatory response syndrome (SIRS) or sepsis, or for detection or diagnosis of a risk to develop or suffer from SIRS or sepsis, in an asymptomatic patient, comprising the steps of determining the level of IL-6 or a variant thereof in a sample from the patient, comparing the level of IL-6 or a variant thereof determined in step a) to a reference level and detecting or diagnosing SIRS, or detecting or diagnosing a risk to develop or suffer from SIRS or sepsis. In some such embodiments, the sample may be isolated at least 2 times at short intervals and the steps of determining and comparing are repeated for each sample.

[0008]In some embodiments, it is provided a method for detecting the level of IL-6 in an asymptomatic patient for detection or diagnosis of a risk to develop or suffer from SIRS or sepsis, comprising the steps of determining the level of IL-6 or a variant thereof in a sample from the patient and comparing the level of IL-6 or a variant thereof determined in the determining step to a reference level. According to various embodiments, based on the comparison it is detected or diagnosed if the patient is at risk to develop or suffer from SIRS or sepsis. In some embodiments, the sample is isolated at least 2 times at short intervals and the determining and comparing steps are repeated for each sample.

[0009]Yet in further embodiments of the instant disclosure, it is also provided a metho...

Problems solved by technology

Prior to this time, various terminologies were used interchangeably, leading to much confusion.

However, no current methods exist for diagnosing SIRS and sepsis, or for predicting the...

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