Tissue fusion method using collagenase for repair of soft tissue

a tissue fusion and soft tissue technology, applied in the field of collagenase, can solve the problems of fibrous tissue sometimes filling the defect gap, tissue often not healing to any significant degree, and fibrous tissue is not mechanically suitable as a replacement for native tissue, etc., to promote the healing process, promote tissue fusion, and accelerate the natural healing process
US20130084320A1Inactive Publication Date: 2013-04-04DEPUY MITEK INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
DEPUY MITEK INC
Publication Date
2013-04-04
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

The present invention provides a method of using locally administered collagenase as a non-invasive means of enhancing cell release from the cartilage or fibrocartilage tissues adjacent to a disease or injury site. The subsequent migration of cells from these tissues into the lesion or wound, followed by deposition of the appropriate extracellular matrix, results in closure of the lesion or fusion of a tissue gap.
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Description

FIELD OF THE INVENTION

[0001] The field of art to which this invention relates is compositions for use in methods of treating and repairing soft tissue, more particularly collagenase compositions and methods of using such compositions for tissue fusion to treat or repair soft tissue.BACKGROUND OF THE INVENTION

[0002] Tissue healing is a complex process involving cells, matrix components and biological factors. Whether the damage to the tissue is caused by injury or disease, a key component of tissue healing is the migration of native cells from surrounding tissue into the wound or lesion, where they can participate in the healing process, whether by interaction with each other, expression of the appropriate biological factors or by the deposition of new extracellular matrix (ECM). In most tissues, this is accomplished by immediate massive matrix degradation via a post-injury response. In the case of vascularized tissue, matrix metalloproteinases (MMPs), e.g., collagenases, are released ...

Claims

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