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Methods And Compositions For Controlling Parasitic Infections Of Animals

a technology for parasitic infections and compositions, applied in the direction of drug compositions, antiparasitic agents, biocides, etc., can solve the problems of increased mortality, reduced production and performance, and reduced feed conversion efficiency, so as to prevent or reduce the harmful effects of protozoal infection or cecal or liver lesions

Active Publication Date: 2014-05-29
ALLTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]In accordance with the purposes of the present invention as described herein, in one aspect of the present invention compositions are provided for preventing or reducing harmful effects of a protozoal infection in an animal suffering from or exposed to a protozoal organism, the composition comprising a yeast cell wall and a preparation derived from oregano. The compositions of the present invention are effective against a variety of protozoal infections, including those caused by protozoal organism selected from Eimeria species, Histomonas species, Cochlosoma species, Hexamita species, and combinations thereof. The compositions may be formulated for admixing with food, or may be provided as a dietary supplement. The oregano preparation may be derived by any means known in the art. In one embodiment, the oregano preparation comprises at least one oil derived from oregano by steam distillation.
[0010]In yet another aspect of the invention, a method for preventing or reducing harmful effects of a protozoal infection in an animal suffering from or exposed to a protozoal organism is provided, comprising administering a composition to the animal comprising a yeast cell wall and a preparation derived from oregano in an amount effective to prevent or reduce protozoal infection or cecal or liver lesions caused by protozoal infection. The compositions may be formulated for admixing with a food, or for feeding as a dietary supplement.
[0011]In still yet another aspect of the invention, a method for preventing or reducing harmful effects of a protozoal infection in an animal is provided, comprising administering a composition to the animal comprising a yeast cell wall, at least one preparation derived from oregano, and at least one plant preparation derived from Yucca in an amount effective to prevent or reduce protozoal infection or cecal lesions caused by protozoal infection.

Problems solved by technology

Protozoal parasitic infections of food species including mammals and birds are characterized by varying degrees of enteritis that results in decreased production and performance.
In extreme cases, increased mortality is seen.
However, even in less severe infections, losses in feed conversion efficiency and decreased weight gains may represent the difference between profit and loss in modern, intensive animal production situations.
Other protozoans, such as Histomonas and Cochlosoma, also lead to necrotic enteritis and increased mortality in severe cases, or in less severe cases poor feed utilization, stunted growth, and overall poor performance.
The economic effects on producers can be catastrophic.
Conventional disinfectants are relatively ineffective against protozoans.
Unfortunately, due to relatively rapid turnaround of hosts (for example, the rapid replacement of flocks in broiler operations), a permanent reservoir of protozoal organisms is often maintained.
However, a significant disadvantage of current drugs used for treatment / control of protozoa is that, over time, treated organisms may become resistant to particular drugs.
Even in cases where shuttle programs are implemented, it is possible that efficacy against protozoal infections will be compromised during the period when drugs are altered.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0019]Anticoccidial efficacy of the compositions of the present invention in poultry was evaluated against a conventional coccidiostat, Salinomycin (60 g / 1000 kg of feed). Three dietary treatments were prepared:[0020]1. Dietary treatment 1: yeast cell wall (1 kg / 1000 kg feed), Yucca preparation (500 g / 1000 kg feed), selenium (0.2 g / 1000 kg feed), and zinc (20 g / 1000 kg feed), included in feed at 1.9 kilograms / 1000 kg feed.[0021]2. Dietary treatment 2: dietary treatment 1 plus 15 g / 1000 kg feed of oregano preparation. The oregano preparation was prepared by steam distillation using methods known in the art to provide an oil, and was added to the dietary treatment as 25 g / 1000 kg feed of a powder comprising 60% oregano oil on a synthetic silica carrier. Dietary treatment 2 was included in the feed at a rate of 1.925 kilograms / 1000 kg feed.[0022]3. Dietary treatment 3: dietary treatment 1 with the Yucca preparation omitted, plus 30 g / ton of oregano preparation as described above, inclu...

example 2

[0029]It was of interest to compare the effects of the compositions of the present invention on a variety of different protozoal parasites. Blackhead is an acute or chronic protozoan disease of fowl, primarily affecting the cecae and liver, caused by Histomonas meleagridis. Symptoms include loss of appetite, increased thirst, drowsiness, and diarrhea.

[0030]A total of 750 1 day old Hubbard Hi-Y broilers were used in this study. Animals were separated into 5 pens (150 birds per pen, day 0 average weight 40 g / broiler chick). Each pen contained 4 water fountains and 4 22 kg capacity feed tubes. Each pen had 2 inches of new wood shaving bedding top dressed with 1 inch of old bedding from a commercial broiler breeder flock, with the exception of a control pen which had 3 inches of new bedding only. The basal feed was a commercial corn-soy based diet. Starter feed was fed from day 0 to 21 of the experiment, and grower feed was fed from day 22 to 42. Diet 1 and diet 2 from Example 1 above w...

example 3

[0043]Cochlosoma anatis is a flagellated protozoan parasite of birds, which is considered a primary source of loss performance and mortality in turkeys. The purpose of this experiment was to compare the effects of the compositions of the present invention to conventional treatments for C. anatis, specifically Histostat (170.3 g / ton of feed) and monensin (72 g / ton of feed) provided as premixes.

[0044]A total of 360 1 day old Hybrid turkey hens were used in this study. Animals were separated into 36 pens (10 birds per pen). With the exception of the unchallenged controls, each pen had 2 inches of new wood shaving bedding top dressed with 1 inch of old bedding from a commercial turkey flock known to have had coccidiosis, to promote industry conditions. The basal feed was a commercial corn-soy based diet (Table 10). Diet 1 and diet 2 from Example 1 above were added to the basal diet as premixes (1.9 kg / ton). All birds and feeds were weighed on days 0, 7, 14, and 21.

TABLE 10Basal diet com...

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Abstract

A composition for preventing or reducing harmful effects of protozoal infection is provided, comprising in one embodiment a yeast cell wall and a preparation derived from oregano. The composition may further include a mineral nutrient selected from selenium and / or zinc. The composition may also include a preparation derived from Yucca. Efficacy of the composition is shown against a variety of protozoal organisms.

Description

TECHNICAL FIELD[0001]This invention relates broadly to novel compositions and methods for controlling parasitic diseases of animals. In particular, the invention relates to compositions and methods for controlling protozoal parasitic infections of animals. Still further, the invention relates to compositions and methods for reducing the harmful effects of protozoal parasitic infections in animals.BACKGROUND OF THE INVENTION[0002]Protozoal parasitic infections of food species including mammals and birds are characterized by varying degrees of enteritis that results in decreased production and performance. In extreme cases, increased mortality is seen. However, even in less severe infections, losses in feed conversion efficiency and decreased weight gains may represent the difference between profit and loss in modern, intensive animal production situations. For example, coccidial infections are known to be a predisposing factor to other syndromes, in particular necrotic enteritis (a b...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/064A61K33/04A61P33/02A61K36/53A61K31/715A61K33/30
CPCA23K10/16A23K10/30A23K20/163A23K50/75A61K31/715A61K33/04A61K33/30A61K36/064A61K36/53A61K36/896A61P33/02A61K2300/00
Inventor DUFFY, CEPTACONNOLLY, AIDAN JOSEPH
Owner ALLTECH CO LTD
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