Compositions and methods for regulating cancer-related signaling pathways

a signaling pathway and cancer technology, applied in the direction of peptides, immunoglobulins against animals/humans, dna/rna fragmentation, etc., can solve the problems that the regulation of tumoral androgen synthesis remains largely undefined, and achieve the effect of increasing the viability of lncap cells

Inactive Publication Date: 2014-11-27
PINSKI JACEK K
View PDF2 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text discusses the impact of LH exposure on prostate cancer cells. The researchers found that LH increased the survival of these cells and also led to the production of testosterone. They also tested the effect of silencing LHR expression and found that it impacted several key survival pathways in prostate cancer. The technical effect of the patent is the demonstration of a potential therapeutic effect of LH in treating prostate cancer.

Problems solved by technology

The technical problem addressed in this patent text relates to understanding how aberrant androgen signals contribute to the growth and spread of prostate cancer, particularly during advanced stages where traditional treatments such as androgen deprivation have limited effectiveness. More specifically, the text discusses the potential role of regulatory mechanisms involved in controlling tumor-related androgen production, which may provide new opportunities for developing more effective therapies against prostate cancer.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compositions and methods for regulating cancer-related signaling pathways
  • Compositions and methods for regulating cancer-related signaling pathways
  • Compositions and methods for regulating cancer-related signaling pathways

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019]Before the compositions and methods are described, it is to be understood that the invention is not limited to the particular methodologies, protocols, cell lines, assays, and reagents described, as these may vary. It is also to be understood that the terminology used herein is intended to describe particular embodiments of the present invention, and is in no way intended to limit the scope of the present invention as set forth in the appended claims.

[0020]Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods, devices, and materials are now described. All technical and patent publications cited herein are incorporated herein by reference in their entirety. Nothing herein is to b...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Electrical resistanceaaaaaaaaaa
Login to view more

Abstract

The use of luteinizing hormone receptor (LHR) as a treatment target in cancer is provided. Data demonstrates that LHR plays an important role in androgen synthesis and signaling pathways critical for prostate cancer progression. When LHR is silenced, there is a significant downregulation of androgen receptor (AR) mRNA and protein expression with a subsequent suppression of PSA expression. Data suggesting that the LH-LHR signaling cascade may be an upstream and viable therapeutic target in castration-resistant prostate cancer (CRPC) is presented.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Owner PINSKI JACEK K
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap