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Predicting suicidality using a combined genomic and clinical risk assessment

a genomic and clinical risk assessment technology, applied in the field of biomarkers, can solve the problems of limiting the step in the ability to intervene, the lack of objective, reliable predictors, and the leading cause of suicide in psychiatric patients, so as to increase the predictive accuracy and improve the predictive accuracy

Inactive Publication Date: 2020-10-01
INDIANA UNIV RES & TECH CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present patent is about predicting who will commit suicide and who will need to be hospitalized due to suicidality. The methods described increase the accuracy of identifying these individuals. Additionally, the patent describes a method for reducing the risk of suicidality in individuals by administering a treatment that reduces the difference between the individual's expression level of a blood biomarker and a reference expression level.

Problems solved by technology

Suicide is a leading cause of death in psychiatric patients, and in society at large.
A limiting step in the ability to intervene is the lack of objective, reliable predictors.
One cannot just ask individuals if they are suicidal, as the desire to not be stopped or future impulsive changes of mind may make their self-report of feelings, thoughts and plans unreliable.
There are currently no objective tools to assess and track changes in suicidal risk without asking the subjects directly.

Method used

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  • Predicting suicidality using a combined genomic and clinical risk assessment
  • Predicting suicidality using a combined genomic and clinical risk assessment
  • Predicting suicidality using a combined genomic and clinical risk assessment

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0113]In this Example, male subjects were analyzed for predicting suicidal ideation and future hospitalizations for suicidality.

[0114]Human Participants

[0115]Data was obtained from four cohorts: one live psychiatric participants discovery cohort (within-participant changes in suicidal ideation; n=37 out of 217); one postmortem coroner's office validation cohort (suicide completers; n=26); and two live psychiatric participants test cohorts—one for predicting suicidal ideation (n=108) and one for predicting future hospitalizations for suicidality (n=157).

[0116]Live psychiatric participants were recruited from the patient population at the Indianapolis VA Medical Center. All participants understood and signed informed consent forms detailing the research goals, procedure, caveats and safeguards. Participants completed diagnostic assessments by an extensive structured clinical interview—Diagnostic Interview for Genetic Studies—at a baseline visit, followed by up to six testing visits, 3...

example 2

[0137]In this Example, female subjects were analyzed for predicting suicidal ideation and future hospitalizations for suicidality.

[0138]Human Participants

[0139]Four cohorts were used: one live psychiatric participants discovery cohort (within-participant changes in suicidal ideation; n=12 out of 51); one postmortem coroner's office validation cohort (suicide completers; n=6); and two live psychiatric participants test cohorts—one for predicting suicidal ideation (n=33), and one for predicting future hospitalizations for suicidality (n=24).

[0140]The live psychiatric participants were part of a larger longitudinal cohort that was continuously being collected. Participants were recruited from the patient population at the Indianapolis VA Medical Center and Indiana University School of Medicine through referrals from care providers, the use of brochures left in plain sight in public places and mental health clinics, and through word of mouth. All participants understood and signed infor...

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Abstract

Biomarkers and methods for screening expression levels of the biomarkers for predicting suicidality (referred herein to suicidal ideation and actions, future hospitalizations and suicide completion) are disclosed. Also disclosed are quantitative questionnaires and mobile applications for assessing affective state and for assessing socio-demographic and psychological suicide risk factors, and their use to compute scores that can predict suicidality. Finally, an algorithm that combines biomarkers and computer apps for identifying subjects who are at risk for committing suicide is disclosed, as well as methods to mitigate and prevent suicidality based on the biomarkers and computer apps.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a Continuation Application and claims priority to U.S. application Ser. No. 15 / 735,304 filed Dec. 11, 2017, which is the U.S. National Stage Application of International Patent Application PCT / US2016 / 036985, filed Jun. 10, 2016, which claims priority to and the benefit of U.S. Provisional Provisional Application No. 62 / 278,707, filed Jan. 14, 2016, and U.S. Provisional Application No. 62 / 174,880, filed on Jun. 12, 2015, the disclosures of which are hereby incorporated by reference in their entireties.STATEMENT OF GOVERNMENT SUPPORT[0002]This invention was made with government support under OD007363 awarded by National Institutes of Health and 2I01CX000139 merit award by the Veterans Administration. The Government has certain rights in the invention.BACKGROUND OF THE DISCLOSURE[0003]The present disclosure relates generally to biomarkers and their use for predicting a subject's risk of suicidality (e.g., suicide ideation...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G16B20/00G16B25/00G01N33/48C12Q1/68C12Q1/6883G16H50/20G16H10/20G16H50/30C12Q1/6876G01N33/68G16B20/20G16B20/30G16B25/10
CPCC12Q1/6883Y02A90/10G01N2800/304G01N2800/50G16B25/00G16H50/20G16H50/30C12Q1/6876G16B20/00C12Q2600/158G01N33/48C12Q1/68G16H10/20G01N33/6893C12Q2600/118A61P25/00A61P25/18A61P25/22A61P25/24G16B20/30G16B25/10G16B20/20G01N2800/30
Inventor NICULESCU, ALEXANDER BOGDAN
Owner INDIANA UNIV RES & TECH CORP
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