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73 results about "Acylglycine" patented technology

Novel Surfactant Composition

A surfactant composition comprising the following elements in the indicated amounts expressed as percentage by weight: (a) 1 to 20% of at least one fatty acyl isethionate compound; (b) 0.1% to 10% of at least one acyl glycinate compound; (c) 0.1% to 20% of at least one alkyl betaine compound; and (d) 60% to 98.8% of water wherein the weight ratio of fatty acyl isethionate to acyl glycinate and alkyl betaine is in the range of 1:0.1 to 1:1 and the composition is clear, concentrated and flowable at and below 25° C. and pH at and below 6.
Owner:GALAXY SURFACTANTS LTD

4-Phenyl piperdine sulfonyl glycine transporter inhibitors

InactiveUS20070105902A1Useful in treatmentBiocideNervous disorderGlycine transportDisease cause
The present invention is directed to compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
Owner:MERCK SHARP & DOHME CORP

Preparation method of (R)-2-(N-tertbutyloxycarbonylamino)biphenylpropanol

The invention discloses a preparation method of (R)-2-(N-tertbutyloxycarbonylamino)biphenylpropanol represented by formula (I). The method comprises the following steps: carrying out an Erlenmeyer-Plochl cyclization reaction on biphenylcarboxaldehyde and N-acylglycine, hydrolyzing or alcoholyzing, and carrying out asymmetric hydrogenation to obtain (R)-N-acylbiphenylalanine or an ester thereof; and carrying out acid hydrolysis, reduction and amino protection on the (R)-N-acylbiphenylalanine or the ester thereof, or carrying out reduction, acid hydrolysis and amino protection on the (R)-N-acylbiphenylalanine or the ester thereof, or directly reducing the (R)-N-acylbiphenylalanine or the ester thereof in order to obtain the product (R)-2-(N-tertbutyloxycarbonylamino)biphenylpropanol. The product is a key intermediate of Sacubitril (AHU-377) which is one of a novel blood pressure reducing medicine LCZ696. The method has the advantages of easily available raw materials, and suitableness for industrial production.
Owner:天台宜生生化科技有限公司

Foam enhancement of fatty acyl glycinate surfactants

A personal care cleansing composition is provided which includes a C10-C24 acyl glycinate salt and a dihydroxypropyl quaternary ammonium salt. Most preferred is sodium cocoyl glycinate in combination with dihydroxypropyl trimethyl ammonium chloride. The quaternary ammonium salt enhances foaming properties of the glycinate salt.
Owner:CONOPCO INC D B A UNILEVER

Preservative-free moisturizing firming cosmetic containing natural and organic ingredients

The invention relates to a group of cosmetic compositions which do not contain preservatives and have the effects of immediate firming, long-acting anti-wrinkle and moisturizing. The cosmetic compositions comprise a freshener, a moisturizer, a cream, an essence and a mask, wherein the moisturizer, the cream and the essence are emulsified products; and a surfactant is organic material coming from the natural plants. In the active ingredients, hydrolysis rhizobian gum and Arabic gum having the immediate firming effect, purified ingredients of natural polysaccharide extracted from oat grains, dipalmitoyl hydroxyproline having the long-acting anti-wrinkle effect, and xylitylglucoside, composition of anhydroxylitol and xylitol, trimethylglycine and sodium hyaluronate having the moisturizing effect are organic materials. The traditional preservatives are not contained in the product, and caprylyl glycine and caprylin substituting for the traditional preservatives come from the plants. The invention relates to an application of the organic materials and materials coming from the plants and a preparation method of the cosmetic.
Owner:GLOBAL COSMETICS HONG KONG CO LTD

Cream-type skin cleansing composition

InactiveUS20070232508A1Easy to useNot to impair effectCosmetic preparationsHair removalPolyolAlcohol
A cream-type skin cleansing composition containing substantially no polyhydric alcohol, which weakly acidic with a pH of 4.0 to 6.0, and soft and smooth with a whity appearance is provided, which is excellent in foamability as well as rinsability and in feeling during application, but avoids from becoming hard at low temperatures, and which can be readily prepared by using a common simple mixer, which contains an N-long-chain acylglycine or a salt thereof, a polyoxyethylene alkyl ether sulfate salt, a betaine type amphoteric surfactant, an inorganic or organic salt and water at a specified amounts and pH.
Owner:AJINOMOTO CO INC

Oil control and acne removal composition and application thereof

The invention relates to an oil control and acne removal composition and an application thereof. The oil control and acne removal composition comprises, by weight, 2-25 parts of water-soluble polyurethane, 5-25 parts of kaolin, 1-5 parts of titanium dioxide, 3-10 parts of dipropylene glycol, 0.1-1 part of zinc pyrrolidone carboxylate and 1-5 parts of an anti-acne active substance. A polyurethane-containing mud film is produced by adopting the aqueous polyurethane as a film forming component and selecting the dipropylene glycol as a film forming assistant, the kaolin controls oil through externally adsorbing the oil, and octanoylglycine, sarcosine, Cinnamomum zeylanicum bark extract and zinc salt of strong acid of pyrrolidone can inhibit the oil secretion through inhibiting 5alpha-reductase, so the composition can effectively inhibit acne propionibacteria of acne skins and effectively restore acnes on oily skins.
Owner:HUNAN YUJIA COSMETICS MFG CO LTD

Cleansing gel and preparation method thereof

The invention discloses cleansing gel and a preparation method thereof. The cleansing gel is prepared from the following components: 25-45 parts of an anionic surfactant selected from alkyl acyl glycinate, alkyl acyl taurate and a mixture of the alkyl acyl glycinate and the alkyl acyl taurate, 3-20 parts of a betaine-type amphoteric surfactant, 4-8 parts of acrylic acid (ester) polymers, 0.2-0.5 part of sodium hydroxide and the balance of water. The product prepared by the method has rich, fine and smooth foam; after using the cleansing gel, a person feels well and does not have obvious residual feeling; furthermore, the cleansing gel is stable in viscosity and is less affected by temperature; the preparation method is simple in technology and free of heating, so that more time is saved.
Owner:HUAANTANG BIOTECH GRP CO LTD

Method for preparing fatty acyl potassium glycine and composition containing surfactant

The invention discloses a method for preparing fatty acyl potassium glycine and a composition containing the surfactant, and belongs to the technical field of fine chemical engineering. According to the technique for synthesizing a fatty acyl potassium glycine type surfactant, fatty acid methyl ester of a natural fat resource is taken as a raw material for synthesizing the fatty acyl potassium glycine type surfactant, that is, fatty acid methyl ester and potassium glycine react in the presence of a phase shifting catalyst PEG2000 to prepare fatty acyl potassium glycine and the composition containing the surfactant. The method is high in raw material utilization rate, high in yield, high in active matter content, high in surface activity, simple in synthesis route, and free of environment pollution and is a green synthesis technique, and products can be directly used without being separated or purified. The invention further discloses a surfactant composition containing the fatty acyl potassium glycine.
Owner:BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY

Method for producing acylglycinates

The invention relates to a method for producing acylglycinates of formula (I) wherein R1 represents a linear or branched, saturated alkanoyl group having between 6 and 30 carbon atoms, or a linear or branched, mono- or polyunsaturated alkenoyl group having between 6 and 30 carbon atoms, and Q+ represents a cation selected from the alkali metals Li+, Na+ and K+, characterised in that glycine comprises fatty acid chloride R1Cl, wherein R1 which has the meaning given in formula (I), is provided in water and in presence of a basic alkali compound, the cations Q+ are selected from Li+, Na+ and K+, but in the absence of organic solvents, is reacted at between 30-35 DEG C, and the proportion of fatty acid chloride R1Cl containing acyl groups R1 having 18 or more carbon atoms, in relation to the total amount of used fatty acid chloride, is less than 2.0% in wt.
Owner:CLARIANT INT LTD

Oil control composition and application thereof

The invention relates to an oil control composition, which is prepared from octanoyl glycine, nicotinamide, inositol, sophorolipid fermentation liquor and a laminaria saccharina extract. The oil control composition prepared from the nicotinamide, the inositol, the octanoyl glycine, the laminaria saccharina extract and the sophorolipid fermentation liquor adjusts oil secretion on the basis of moisture retention, and establishes a three-dimensional balance oil control technology aiming at inhibition for the activity of three target points, i.e., lipase, 5 alpha-reductase and sebum flow regulation.
Owner:HUNAN YUJIA COSMETICS MFG CO LTD

Cold processable non-toxic preservative composition for home and personal care products

Disclosed herein is a cold-processable antimicrobial composition in non-dusting solid form, free from toxic antimicrobial comprising, a) N-capryloyl glycine (Formula I), b) N-undecylenoyl glycine (Formula II), c) benzoic acid (Formula III) and d) sodium dehydroacetate (Formula IV) for use in personal care and home care products. The invention further discloses a process for preparation of the antimicrobial composition and ease of its incorporation in various personal and home products.
Owner:GALAXY SURFACTANTS

Preparation method for aryl acetic acid derivative

The invention discloses a preparation method for an aryl acetic acid derivative. The preparation method comprises the following specific steps of: (1) adding sodium acetate, acetic anhydride and a cyclization agent into aryl methanal or alkyl original aliphatic aldehyde having more than four carbon atoms, and performing cyclization reaction to obtain an aryl oxazolone derivative, wherein the cyclization agent is N-acyl-glycine or an analogue thereof; and (2) uniformly mixing the aryl oxazolone derivative and aqueous alkali, adding an oxidizing agent and performing oxidization reaction to obtain the corresponding aryl acetic acid derivative, wherein the alkali is sodium hydroxide solution or potassium hydroxide, and the oxidizing agent is peroxy acid. Compared with the prior art, the method is mild in reaction condition, short in reaction steps, short in preparation cycle, low in cost, simple in posttreatment and low in environmental pollution, and is applicable for preparation of the aryl acetic acid derivative; by the method, the raw materials are readily available; moreover, the product prepared by the method is high in purity and stable in quality, and the method is suitable for large-scale industrial production.
Owner:GUILIN NORMAL COLLEGE

Composition and acne-removing cosmetic containing same

InactiveCN108478518AInhibition evokedInhibit inflammationCosmetic preparationsAntipyreticCentella asiatica extractAzadirachta indica leaf extract
The invention relates to the field of cosmetics, in particular to a composition and an acne-removing cosmetic containing the same. The composition comprises glycolic acid, lactobacillus / pear juice fermented product filtrate, a xanthate bark extract, a white willow bark extract, a rehmannia chinensis root extract, an azadirachta indica leaf extract, a glycine ussuriensis extract, nicotinamide, octyl glycine, a radix sophorae root extract, a radix salvia miltiorrhizae extract, silanediol salicylate, zinc pyrrolidone carboxylate, quercetin, L-magnesium ascorbate phosphate, a centella extract andmenthoxypropanediol. The composition and the acne-removing cosmetic containing the same have the effects of inhibiting induction, inhibiting inflammation and promoting healing.
Owner:HUNAN YUJIA COSMETICS MFG CO LTD

Composition and cosmetic containing same for inhibiting acne inflammation

The invention relates to the field of cosmetics, in particular to a composition and a cosmetic containing the same for inhibiting acne inflammation. The composition comprises a rhizoma dioscoreae bulbiferae bark extract, an azadirachta indica leaf extract, octanoyl glycine, a radix sophorae flavescentis extract, a radix salviae miltiorrhizae extract, silanediol salicylate, quercetin, a herba centellae extract and L-magnesium ascorbyl phosphate. The composition and the cosmetic containing the same have the effect of suppressing acne inflammation.
Owner:HUNAN YUJIA COSMETICS MFG CO LTD

Skin oil balance composite and application thereof

The invention relates to a skin oil balance composite and application thereof. The skin oil balance composite comprises nicotinamide, inositol, capryloylglycine and an oil control plant extractive, wherein the oil control plant extractive comprises an chamomile extractive, an nettle extractive, a meadow pine extractive, a rosemary extractive, a melissa extractive, a buckeye seed extractive, a salvia extractive and a coltsfoot extractive. The skin oil balance composite aims at the problems of scalp oil, pruritus, alopecia and the like of the scalp and adopts the nicotinamide, inositol, capryloylglycine and oil control plant extractive to maintain oil balance, and scalp problems can be effectively solved.
Owner:HUNAN YUJIA COSMETICS MFG CO LTD

Scalp maintenance composite and application thereof

The invention relates to a scalp maintenance composite and application thereof. The scalp maintenance composite comprises a skin grease balance composite, a skin microecological balance composite anda skin barrier repairing composite. By aiming at the problems of the drying, pruritus, decrustation, alopecia and the like of the scalp, the scalp maintenance composite adopts sodium pyrrolidonecarboxylate and ecdysterone to repair the scalp barrier, adopts itching relieving anti-allergy composite (Comthing Tetra) to lower susceptivity, adopts nicotinamide, inositol, capryloylglycine and an oil controlling plant composite (M82N) to maintain grease balance, adopts a metabolic balance composite (M3) to realize metabolic balance and adopts zizyphus joazeiro bark extractives, a first balance composite (ecological nutrient solution) and a second balance composite (Fensebiome Peptide) to achieve microorganism flora balance, and scalp problems are effectively alleviated.
Owner:HUNAN YUJIA COSMETICS MFG CO LTD

Antiallergic composition and application thereof in cosmetics

The invention discloses an antiallergic composition and an application thereof in cosmetics. The antiallergic composition comprises the following components in parts by mass: 20-40 parts of flos lonicerae, 10-18 parts of chamomile, 8-13 parts of anthocyanidin, 5-10 parts of a salicylic acid, 8-6 parts of astragalus membranaceus, 2-5 parts of serine, 1-4 parts of phytantriol, 2-4 parts of corn starch sulfonated succinate, 1-1.8 parts of caprylyl glycine, 0.08-1.46 parts of a nicotinic acid, 0.3-1.2 parts of carboxymethyl cellulose, 1.2-3.5 parts of benzoyl peroxide, 0.5-1.1 parts of isopropyl myristate, 0-1 part of an antioxidant, and 0-3 parts of a preservative. The antiallergic composition is composed of traditional Chinese medicines and western medicines in proportion, so that the antiallergic composition is good in antiallergic effect, and can significantly improve the allergic symptoms of the skin after being applied in cosmetics.
Owner:SUZHOU VIVOTIDE BIOTECH

Process for the preparation of enantiomerically-enriched cyclopropylalanine derivates

Disclosed are processes for the preparation of enantiomerically-enriched cyclopropylalanine derivatives by the hydrogenation of certain enamides in the presence of a catalyst comprising a transition metal and a substantially enantiomerically-pure bis-phosphine catalyst and certain novel enamide ester compounds which are intermediates in the processes. The processes include novel 2-step and 3-step processes for the preparation of enantiomerically-enriched cyclopropylalanine derivatives. The two-step process comprises the steps of reacting cyclopropanecarboxaldehyde with a substituted phosphorylglycine to afford an enamide ester which then is hydrogenated in the presence of a catalyst comprising a transition metal and a substantially enantiomerically-pure bis-phosphine catalyst. The three-step process comprises the steps of forming an azlactone from an N-acylglycine and cyclopropanecarboxaldehyde, converting the azlactone to the aforesaid enamide which then is hydrogenated in the presence of a catalyst comprising a transition metal and a substantially enantiomerically-pure bis-phosphine catalyst.
Owner:JOHNSON MATTHEY PLC

Glyoxylate assays and their use of inden tifying natural amidated compounds

Methods for detecting and assaying for glyoxylate, include enzyme-based assays and / or assays for hydrogen peroxide following liberation of hydrogen peroxide from glyoxylate, are disclosed. In some embodiments, the invention is directed to methods for assaying for glyoxylate produced by the reaction of peptidylglycine alpha-amidating monooxygenase (PAM). The subject invention also concerns methods for assaying for the enzyme peptidylglycine alpha-amidating monooxygenase and / or its substrates. The detection of glyoxylate is indicative of the presence of PAM and / or its substrates. The subject invention also concerns methods for screening for peptide hormones, amidated fatty acids, any N-acyl-glycine or N-aryl-glycine conjugated molecule, and generally compounds having a glycine reside in free acid form and attached to a carbonyl group.
Owner:UNIGENE LABORATORIES

Byosynthetic Production of Acyl Amino Acids

The present invention relates to a cell for producing acyl glycinates wherein the cell is genetically modified to compriseat least a first genetic mutation that increases the expression relative to the wild type cell of an amino acid-N-acyl-transferase,at least a second genetic mutation that increases the expression relative to the wild type cell of an acyl-CoA synthetase, andat least a third genetic mutation that decreases the expression relative to the wild type cell of at least one enzyme selected from the group consisting of an enzyme of the glycine cleavage system, glycine hydroxymethyltransferase (GlyA) and threonine aldolase (LtaE).
Owner:EVONIK DEGUSSA GMBH

Water supplementing-type bath lotion and preparation method thereof

The invention discloses a water supplementing-type bath lotion and a preparation method thereof. The water supplementing-type bath lotion comprises the following raw materials by percentage: 2-7% of lauric acid, 5-8% of myristic acid, 0.5-1.5% of stearic acid, 2-5% of potassium hydroxide, 6-12% of a cocamidopropyl MIPA thickening agent, 0.5-1.5% of coconut oil acylglycine salt, 5-10% of glycerin,70-60% of water, 0.2-1% of an antiseptic, and 1-3% of aloe, tea and Chinese ilex bark extracts. By adding an aloe extract, microbial fermentation is used for biological extraction, the aloe extract isbenefit for skin pore convergence, and is capable of smoothing the skin, magnetic water is used during an extraction process, active factors of the skin is increased, water supplementing effect is enhanced, water retention performance is increased, skin absorption is convenient, coconut oil acylglycine salt can effectively improve the system foams, the steps of drying, crushing, and sieving filtering are carried out on the tea and Chinese ilex bark, and the anticorrosion performance of the bath lotion is increased.
Owner:佛山市欧若拉生物科技有限公司

Anti-allergic cosmetic and production process thereof

The present invention discloses an anti-allergic cosmetic and a production process thereof. The anti-allergic cosmetic is prepared ?from the following raw materials: attapulgite, caprylylglycine, (-)-alpha-bisabolol, titanium dioxide, fish oil, an aroma agent, fruit acid and deionized water. The cosmetic can be applicable for all types of people. With trials, no allergy symptom is generated aftercosmetic allergy people use the product of the present invention, and a plurality functions of anti-allergy, whitening, water retention, wrinkle removing, aroma increasing, and the like are provided.
Owner:曾技

Special ultrafine tiopronin powder lyophilized preparation and preparation method thereof

The invention discloses a special ultrafine tiopronin powder lyophilized preparation and a preparation method thereof. The preparation method comprises the following steps: reacting 2-chloropropionic acid with phosphorus trichloride to generate 2-chloropropionyl chloride, reacting 2-chloropropionyl chloride with glycine to generate 2-chloropropionyl glycine, reacting 2-chloropropionyl glycine with sodium disulfide, reducing by zinc powder to obtain crude tiopronin, purifying, carrying out air jet ultrafine crushing, and lyophilizing to prepare the special ultrafine tiopronin powder lyophilized preparation. The special ultrafine tiopronin powder lyophilized preparation has the advantages of good clarity, high stability, high purity, few impurities, small particle size, large specific surface area, good solubility, small toxic side effects, difficult allergy and the like.
Owner:杭州长典老一元健康管理有限公司

Amino acid anionic-cationic surfactant based composite foaming agent

InactiveCN104446088AStrong foaming abilityHigh foaming ratioPalmitoyl glycineFoaming agent
The invention discloses an amino acid anionic-cationic surfactant based composite foaming agent. The composite foaming agent is prepared by mixing an amino acid anionic surfactant with an amino acid cationic surfactant at a mass ratio of 1:(1-4), wherein the amino acid anionic surfactant is sodium lauroyl glycine, sodium palmitoyl glycine or sodium octadecanoyl glycine, and the amino acid cationic surfactant is dodecyl trimethyl ammonium bromide, hexadecyl trimethyl ammonium bromide or octadecyl trimethyl ammonium bromide. Because the two different types of surfactants act synergistically, the surface tension of the amino acid anionic-cationic surfactant based composite solution can be reduced, the thickness of the foam film can be increased effectively, and further the strength of the foam can be enhanced. The composite foaming agent disclosed by the invention contains a few components, does not contain any additive, can foam quickly in quantity and has good stability.
Owner:SHAANXI NORMAL UNIV

Isotropic, flowable, skin ph aqueous cleansing compositions comprising n-acyl glycinates as primary surfactants

ActiveUS20160228343A1Affects the isotropy or clarity and benefitsEasy maintenanceCosmetic preparationsHair cosmeticsShower gelSURFACTANT BLEND
Disclosed is an aqueous cleansing composition comprising N-acyl glycinates as primary surfactants wherein the said cleansing compositions are isotropic and flowable at skin pH. The aqueous cleansing compositions are isotropic and flowable at temperature 25° C. Also disclosed is the use of these aqueous cleansing compositions in preparing isotropic aqueous personal skin and hair cleansing formulations such as body wash, shower gels, shampoos, and other such products.
Owner:GALAXY SURFACTANTS LTD

Liquid personal cleansing composition

The invention relates to aqueous skin cleansing compositions. Specific amounts and chain length of acyl glycinate and acyl glutamate when used in specified ratios, have been found to unexpectedly enhance lather volume and texture, as well as provide superior mildness.
Owner:CONOPCO INC D B A UNILEVER
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