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54 results about "Intracellular signal transduction pathway" patented technology

Pathways of Intracellular Signal Transduction. Most cell surface receptors stimulate intracellular target enzymes, which may be either directly linked or indirectly coupled to receptors by G proteins.

Compounds useful as inhibitors of atr kinase

InactiveUS20120046295A1Surprising synergyInhibitor usedBiocideOrganic chemistryKinase inhibitionPyrrole
The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula I:
wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

Compounds Useful as Inhibitors of ATR Kinase

InactiveUS20130115313A1Good pK profileReduce gapHeavy metal active ingredientsBiocideDiseaseKinase inhibition
Compounds Useful as Inhibitors of ATR Kinase
Compounds Useful as Inhibitors of ATR Kinase
Compounds Useful as Inhibitors of ATR Kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase

InactiveUS20120027874A1Surprising synergyInhibitor usedOrganic active ingredientsHeavy metal active ingredientsDiseasePyrazine
The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula I:
wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

Compounds Useful as Inhibitors of ATR Kinase

InactiveUS20130115314A1Surprising synergyHeavy metal active ingredientsBiocideDiseaseOrganic chemistry
Compounds Useful as Inhibitors of ATR Kinase
Compounds Useful as Inhibitors of ATR Kinase
Compounds Useful as Inhibitors of ATR Kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase

ActiveUS20140163000A1Surprising synergyBiocideNervous disorderKinase inhibitionMedicinal chemistry
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula I:
or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Moreover, The compounds of this invention have formula I-A:
or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase

ActiveUS20120177748A1Surprising synergyInhibitor usedHeavy metal active ingredientsBiocideDiseasePyridine
The present invention relates to pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula III:
wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of ATR kinase

InactiveUS20120035407A1Antibacterial agentsOrganic active ingredientsDiseaseOrganic chemistry
The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula II:wherein the variables are as defined herein.
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
View all
Owner:VERTEX PHARMA INC

Compounds Useful as Inhibitors of ATR Kinase

InactiveUS20130089625A1Excellent tumor regressionEnhance the imageBiocideHeavy metal active ingredientsDiseaseOrganic chemistry
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; solid forms of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I-1:wherein the variables are as defined herein.Additionally, the compounds of this invention have formula II:or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.
Compounds Useful as Inhibitors of ATR Kinase
Compounds Useful as Inhibitors of ATR Kinase
Compounds Useful as Inhibitors of ATR Kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase

InactiveUS20130095193A1Surprising synergyInhibitor usedHeavy metal active ingredientsBiocideDiseasePharmaceutical medicine
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

Compounds Useful as Inhibitors of ATR Kinase

InactiveUS20130096139A1Good pK profileReduce gapOrganic active ingredientsOrganic chemistryDiseaseOrganic chemistry
Compounds Useful as Inhibitors of ATR Kinase
Compounds Useful as Inhibitors of ATR Kinase
Compounds Useful as Inhibitors of ATR Kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of ATR kinase

ActiveUS20130018035A1BiocideOrganic chemistryPyrrolePathology diagnosis
The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:wherein the variables are as defined herein.
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase

ActiveUS20100222318A1Surprising synergyInhibitor usedBiocideGroup 5/15 element organic compoundsDiseaseKinase inhibition
The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula I:
wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

Compounds Useful as Inhibitors of ATR Kinase

InactiveUS20130115310A1Good pK profileReduce gapBiocideHeavy metal active ingredientsDiseaseOrganic chemistry
Compounds Useful as Inhibitors of ATR Kinase
Compounds Useful as Inhibitors of ATR Kinase
Compounds Useful as Inhibitors of ATR Kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase

InactiveUS20120178756A1Surprising synergyInhibitor usedOrganic active ingredientsOrganic chemistryDiseasePyrazine
The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula I:
wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of ATR kinase

ActiveUS8410112B2Heavy metal active ingredientsBiocideDiseasePyrazine
The present disclosure relates to pyrazine compounds of formula I:wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase

ActiveUS20130017273A1Surprising synergyInhibitor usedHeavy metal active ingredientsBiocideDiseasePyrrole
The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula I:
wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase

ActiveUS20120035408A1Surprising synergyInhibitor usedOrganic active ingredientsOrganic chemistryDiseasePyridine
The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula V:
wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of ATR kinase

ActiveUS20120122884A1Surprising synergyInhibitor usedOrganic active ingredientsOrganic chemistryDiseasePyrazine
The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula IV:
wherein the variables are as defined herein.
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of ATR kinase

InactiveUS8962631B2Antibacterial agentsOrganic active ingredientsDiseasePyrazine
The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula II:wherein the variables are as defined herein.
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of ATR kinase

InactiveUS8969360B2Organic active ingredientsBiocideDiseaseOrganic chemistry
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:or a pharmaceutically acceptable salt, wherein the variables R1, R2, R3, and R4 are as defined herein.
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase

ActiveUS20140249157A1Surprising synergyBiocideOrganic active ingredientsKinase inhibitionMedicinal chemistry
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:or a pharmaceutically acceptable salt, wherein the variables are as defined herein.Moreover, The compounds of this invention have formula I-A:or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of ATR kinase

InactiveUS20150158868A1BiocideOrganic chemistryDiseaseMedicinal chemistry
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention are represented by formula I-A and formula I-B:
or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase

InactiveUS20140275009A1BiocideOrganic chemistryDiseasePharmaceutical medicine
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula I:
or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase and combination therapies thereof

ActiveUS20160030424A1BiocideHeavy metal active ingredientsDiseaseCombination therapy
The present invention relates to compounds useful as inhibitors of ATR protein kinase and combination therapies thereof. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase and combination therapies thereof
Compounds useful as inhibitors of atr kinase and combination therapies thereof
Compounds useful as inhibitors of atr kinase and combination therapies thereof
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of ATR kinase

InactiveUS8957078B2BiocideOrganic chemistryDiseasePharmaceutical medicine
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of ATR kinase

InactiveUS8841449B2Good pK profileReduce gapHeavy metal active ingredientsBiocideDiseaseKinase inhibition
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of ATR kinase

InactiveUS8912198B2BiocideOrganic active ingredientsDiseaseMedicinal chemistry
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
Compounds useful as inhibitors of ATR kinase
View all
Owner:VERTEX PHARMA INC

Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase

ActiveUS8822469B2BiocideOrganic chemistryPyrazineKinase inhibition
The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:wherein the variables are as defined herein.
Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase
Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase
Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase

InactiveUS20140107093A1BiocideOrganic active ingredientsDiseaseMedicinal chemistry
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

Compounds useful as inhibitors of atr kinase

InactiveUS20140275130A1Organic active ingredientsBiocideComparative evaluationIntracellular signal transduction pathway
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have the formula I:
Additionally, the compounds of this invention have the formula I-A:
or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
Compounds useful as inhibitors of atr kinase
View all
Owner:VERTEX PHARMA INC

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