The invention discloses a composite door and window grouting mortar and a use method thereof, wherein the composite door and window grouting mortar comprises a powder material and a liquid material, the powder material comprises, by weight, 50-65 parts of cement, 15-25 parts of a mineral admixture, 10-16 parts of a compacting agent, 0.2-0.4 part of an anti-shrinking agent, 3-5 parts of polystyreneparticles, 0.1-0.3 part of cellulose ether, 0.3-0.5 part of a thixotropic agent, 0.2-0.4 part of a water repellent, and 0.05-0.3 part of a water reducing agent, and the liquid material comprises, byweight, 20-35 parts of a polymer emulsion, 0.1-0.5 part of a defoamer, 0.05-0.6 part of a dispersant, 0.03-0.2 part of an antibacterial agent, and 60-70 parts of water. The invention further disclosesa use method of the composite door and window grouting mortar. According to the present invention, the composite door and window grouting mortar has advantages of excellent bonding ability, excellentimpermeability, good reinforcement ability, good anti-deformation ability, shrink cracking resistance, simple use and construction period shortening.