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Methocarbamol dry mixing suspension

A technology of methocarbamol and dry suspension, which is applied in the field of new drug preparations and can solve problems such as low bioavailability

Inactive Publication Date: 2007-09-26
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thereby overcoming the defect that Methocarbamol is insoluble in water and low in bioavailability,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Methocarbamol 500g

[0092] Hypromellose (E 5 -LV) 100g

[0093] Microcrystalline Cellulose 200g

[0094] Sucrose 200g

[0095] 50% ethanol aqueous solution 20ml

[0096] Make 1000 bags

[0097] 1. Preparation and processing of raw and auxiliary materials:

[0098] Crush Methocarbamol through a 100-mesh sieve, hypromellose E 5 -LV, microcrystalline cellulose, and sucrose are pulverized and passed through a 100-mesh sieve.

[0099] 2 Weighing and mixing:

[0100] 2-1 Weigh the above-mentioned raw and auxiliary materials according to the prescription amount and calculate the feeding amount after double checking.

[0101] 2-2 Put the above raw and auxiliary materials into the mixer and mix them evenly.

[0102] 3 Granulation:

[0103] 3-1 Making soft materials Use 50% ethanol to make soft materials, and granulate them with 20-mesh nylon mesh. The granules should be free of fine powder and neat without long strips.

[010...

Embodiment 2

[0110] Methocarbamol 250g

[0111] Hypromellose (E 5 -LV) 50g

[0112] Microcrystalline Cellulose 100g

[0113] Sucrose 100g

[0114] 50% ethanol aqueous solution 10ml

[0115] Make 1000 bags

[0116] 2. Preparation and processing of raw and auxiliary materials:

[0117] Crush Methocarbamol through a 100-mesh sieve, hypromellose E 5 -LV, microcrystalline cellulose, and sucrose are pulverized and passed through a 100-mesh sieve.

[0118] 2 Weighing and mixing:

[0119] 2-1 Weigh the above-mentioned raw and auxiliary materials according to the prescription amount and calculate the feeding amount after double checking.

[0120] 2-2 Put the above raw and auxiliary materials into the mixer and mix them evenly.

[0121] 3 Granulation:

[0122] 3-1 The soft material is made of 50% ethanol, and granulated with a 20-mesh nylon net. The granules should be free of fine powder and neat without long strips.

[0123] 3-2 Drying: Dry in a ...

Embodiment 3

[0129] Methocarbamol 1000g

[0130] Hypromellose (E 5 -LV) 200g

[0131] Microcrystalline Cellulose 400g

[0132] Sucrose 400g

[0133] 50% ethanol aqueous solution 50ml

[0134]Make 1000 bags

[0135] Preparation and handling of raw materials:

[0136] Crush Methocarbamol through a 100-mesh sieve, hypromellose E 5 -LV, microcrystalline cellulose, and sucrose are pulverized and passed through a 100-mesh sieve.

[0137] 2 Weighing and mixing:

[0138] 2-1 Weigh the above-mentioned raw and auxiliary materials according to the prescription amount and calculate the feeding amount after double checking.

[0139] 2-2 Put the above raw and auxiliary materials into the mixer and mix them evenly.

[0140] 3 Granulation:

[0141] 3-1 Making soft materials Use 50% ethanol to make soft materials, and granulate them with 20-mesh nylon mesh. The granules should be free of fine powder and neat without long strips.

[0142] 3-2 Drying: Dry in a dr...

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PUM

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Abstract

A dry suspension of methocarbamol contains methocarbamol and the pharmacologically acceptable carrier including cellulose derivative chosen from hydroxypropyl methyl cellulose, and microcrystalline cellulose, flavouring (cane sugar), and adhesive (the mixture of alcohol and water).

Description

technical field [0001] The invention relates to a new drug preparation, in particular to a dry suspension of muscle relaxant methocarbamol. Background technique [0002] Muscle relaxants are drugs that reduce the tone of skeletal muscles (striated muscles). It is mainly divided into neuromuscular blocking drugs and central skeletal muscle relaxants. The former mainly acts on nerve synapses and is usually used as an anesthesia adjuvant drug, such as chlorsicurine, atracurium besylate, and pipecuronium bromide etc. belong to this class of drugs; while the latter mainly acts on the central nervous system (outside of synapses), and is usually used to relieve skeletal muscle spasm and the pain caused by it, such as Eperisone Hydrochloride Granules, Chlorzoxazone, Methocarbamol etc. belong to this class of drugs. Among them, Methocarbamol has been widely used clinically at home and abroad in the 1980s. It is clinically suitable for the treatment of various acute and chronic sof...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/17A61K9/16A61P21/02
Inventor 严洁
Owner TIANJIN HANKANG PHARMA BIOTECH
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