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Stomach nourishing dispersible tablet with aucklandia root and amomum fruit and its preparation method

A technology for nourishing the stomach and dispersible tablets with fragrant sand, which is applied in the directions of medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, and pill delivery, etc. And other issues

Inactive Publication Date: 2007-10-17
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to a large number of literatures, various volatile oils contained in the Xiangsha Yangwei preparation play a very important pharmacological role in its therapeutic effect. Insufficient content of volatile oil will reduce the efficacy of the medicine. The traditional Chinese medicine preparation Xiangsha Yangwei Pill and on this basis The improved Xiangsha Yangwei Granules, Xiangsha Yangwei Capsules, Xiangsha Yangwei Tablets, Xiangsha Yangwei Oral Liquid and other series of Xiangsha Yangwei preparations will volatilize a large amount of volatile oil due to the high temperature in the preparation process And the loss; the part where these drugs produce drug effect is in the stomach of the patient. Factors such as delay and slow release of active ingredients of the drug not only affect the curative effect of the drug, but also stimulate the stomach of the patient, limiting its application
Patent application No. 01100749 is to use nanotechnology for the raw materials of Xiangsha Nourishing Stomach Preparation, but the nano-grinding technology is difficult and requires high equipment. At the same time, during the milling process, due to the rupture of the cell wall, a large amount of volatile oil can be lost. And cause drug effect to reduce; Patent Application No. 03118954 is Xiangsha nourishing stomach two-phase hard capsule, before preparing hard capsule, volatile oil will be made into soft capsule or capsule earlier, preparation requirement is high, and process is complicated, hard capsule after molding It is more difficult to disintegrate in the stomach, the active ingredients are more difficult to dissolve, and cause different degrees of stimulation to the stomach

Method used

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  • Stomach nourishing dispersible tablet with aucklandia root and amomum fruit and its preparation method
  • Stomach nourishing dispersible tablet with aucklandia root and amomum fruit and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0030]According to the Ministry of Health of the People's Republic of China "Drug Standard Traditional Chinese Medicine Prescriptions" Volume 20, page 253 (Pharmacopoeia Committee of the Ministry of Health of the People's Republic of China, the raw material composition and dosage ratio of Xiangsha Yangwei Soft Capsules), take woody 154g , Amomum 154g, Atractylodes macrocephala 221g, Chenpi 221g, Poria cocos 221g, Pinellia 221g, Cyperus cyperi 154g, Citrus aurantium 154g, White cardamom 154g, Ginger Magnolia officinalis 154g, Patchouli 154g, Licorice 66g, Ginger 66g, Jujube 110g.

[0031] Preparation method:

[0032] (1) Preparation of Xiangsha Nourishing Stomach Volatile Oil Inclusion Compound

[0033] Extract volatile oil from woody, amomum, patchouli, white cardamom, and tangerine peel with steam distillation to obtain 18ml of volatile oil. The extracted volatile oil is made into a 50% ethanol solution by volume, and added to a saturated solution containing 180g of β-cyclod...

Embodiment 2

[0055] According to the prescription and method of Example 1, collect 16.5ml of volatile oil of Xiangsha Nourishing Stomach, add it to a saturated solution containing 150g of β-cyclodextrin and carry out inclusion complexation at 20°C for 2 hours, after inclusion, obtain 48g of volatile oil inclusion compound, and obtain Xiangsha Yangwei dry extract powder 93g, microcrystalline cellulose is adjusted to 150g, sodium carboxymethyl starch is adjusted to 55g, other preparation prescriptions are unchanged according to Example 1, and Xiangsha Yangwei dispersible tablets are prepared according to Example 1, each tablet Theoretical sheet weight 0.5g, carry out quality inspection by the quality inspection method of embodiment 1, each meets the regulation, wherein carries out the result of dispersion uniformity inspection, disintegrates completely and the time that can pass through No. 2 sieve is 2 minutes and 45 seconds.

Embodiment 3

[0057] According to the prescription and method of Example 1, collect 16ml of volatile oil from Xiangsha Yangwei, add it to a saturated solution containing 100g of hydroxypropyl β-cyclodextrin, and carry out inclusion complexation at 20°C for 2 hours. After inclusion, 45g of volatile oil inclusion compound is obtained. Xiangsha nourishing stomach dry extract powder 95g, microcrystalline cellulose is adjusted to 150g, carboxymethyl starch sodium is adjusted to 55g, other preparation prescription is unchanged by embodiment 1, prepares Xiangsha nourishing stomach dispersible tablet according to embodiment 1, Each theoretical tablet weighs 0.5g, and the quality inspection is carried out according to the quality inspection method of Example 1, and all items meet the requirements. The result of the dispersion uniformity inspection is that the time for completely disintegrating and passing through the No. 2 sieve is 2 minutes and 20 seconds. bell.

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Abstract

The invention relates to a stomach nourishing dispersible tablet with aucklandia root and amomum fruit and its preparation method which comprises, choosing raw material according to official drug standards, extracting volatile oil and extractive, preparing inclusion compound from the volatile oil by employing beta-cyclodextrin or hydroxypropyl beta-cyclodextrin, concentrating and drying the extractive into dried extract powder, choosing right amount of microcrystalline cellulose, stevioside, mannitol, sodium carboxymethylstarch, miropowdered silica gel, low substituted methylcellulose propylene glycol ether as dispersible tablets excipient, low temperation drying the obtained particles, tabletting to obtain the dispersible tablets.

Description

technical field [0001] The invention relates to a Xiangsha nourishing stomach dispersible tablet. Background technique [0002] Xiangsha Nourishing Stomach Preparation is a medicine that warms the stomach and relieves stomach discomfort such as indigestion, vomiting of acid water, indigestion, and epigastric pain. Twenty volumes (the Pharmacopoeia Commission of the Ministry of Health of the People's Republic of China 1998) just recorded Xiangsha Yangwei Oral Liquid and Xiangsha Yangwei Soft Capsules. According to a large number of literatures, various volatile oils contained in the Xiangsha Yangwei preparation play a very important pharmacological role in its therapeutic effect. Insufficient content of volatile oil will reduce the efficacy of the medicine. In the preparation process of the improved Xiangsha Yangwei Granules, Xiangsha Yangwei Capsules, Xiangsha Yangwei Tablets, Xiangsha Yangwei Oral Liquid and other series of Xiangsha Yangwei preparations, a large amount of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/9068A61K36/9064A61K36/8905A61K36/8888A61K36/752A61K36/75A61K36/725A61K36/575A61K36/53A61K36/484A61K36/285A61K36/284A61K36/076A61P1/14
Inventor 周国平
Owner XIANGTAN UNIV