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Gel containing betulaprenol from ginkgo leaves and its preparing method

A kind of technology of leaf polyprenol gel and polyprenol gel is applied in the field of gel containing ginkgo biloba polyprenol and its preparation, which can solve the problems of no polyprenol and achieve Effects of promoting healing, strong operability, and easy spreading

Inactive Publication Date: 2008-04-30
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And there is no report of any dosage form of polyprenol in China

Method used

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  • Gel containing betulaprenol from ginkgo leaves and its preparing method
  • Gel containing betulaprenol from ginkgo leaves and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 polyprenol gel is made from the raw materials of following weight ratio:

[0028] Calculated according to the content per 100g of gel:

[0029] 15g of polyprenol, 15g of organic bentonite, 25g of vegetable oil, 40g of liquid paraffin, 804g of Tween, 0.5g of VE, and 0.5g of essence.

Embodiment 2

[0030] The preparation method of embodiment 2 polyprenol gel, its preparation steps are as follows:

[0031] 1. Extract polyprenol from Ginkgo biloba:

[0032] (1) Take 10kg of dried ginkgo leaves, crush them, put them into a Soxhlet extractor, add 120kg of petroleum ether (60-90°C), extract for 4 hours, filter, add 50kg of petroleum ether (60-90°C) to extract the residue For the second time, combine the filtrates. Add 5% KOH ethanol solution to the filtrate, hydrolyze at room temperature for 3 hours, and let stand to separate layers;

[0033] (2) Adsorb the organic phase containing polyprenyl alcohol compounds with macroporous resin NKA-II, carry out column adsorption at a flow rate of 0.2BV / min, and elute with petroleum ether / acetone 8:2 after saturation, and the eluted The solution was concentrated under reduced pressure to obtain 70% to 80% crude polyprenol extract;

[0034] (3) The above-mentioned crude polyprenol was subjected to silica gel column chromatography, and ...

Embodiment 3

[0038] Embodiment 3 polyprenol gel preparation method, its preparation steps are:

[0039] 1. Extract polyprenol from Ginkgo biloba:

[0040] (1) Take 15kg of dried ginkgo leaves, crush them, put them into a Soxhlet extractor, add 180kg of petroleum ether (60-90°C), extract for 4 hours, filter, and extract the residue with 60kg of petroleum ether (60-90°C) For the second time, combine the filtrates. The filtrate was added with methanol solution of 5% KOH, the reaction temperature was 50°C, hydrolyzed for 4 hours, and allowed to stand for separation;

[0041] (2) Adsorb the organic phase containing polyprenyl alcohol compounds with macroporous resin NKA-9, carry out column adsorption at a flow rate of 0.2BV / min, and elute with petroleum ether / acetone 8:1 after saturation, and the eluted The solution was concentrated under reduced pressure to obtain 70% to 80% crude polyprenol extract;

[0042] (3) The above-mentioned crude polyprenol was subjected to silica gel column chroma...

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PUM

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Abstract

The present invention discloses a gel preparation containing polypentenol extracted from ginkgo leaf and its preparation method. Said gel preparation is made up by using the components of polypentenol, liquid paraffine wax, Tween-80, organic bentonite, edible soybean oil. VE and essence, etc. Besides, said invention also provides the concrete steps of said preparation method.

Description

1. Technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a gel containing ginkgo biloba polyprenol and a preparation method thereof. 2. Background technology [0002] Ginkgo biloba (Folium Ginkgo) is a traditional Chinese medicine. The main medicinal active ingredients in Ginkgo biloba extract (GBE) and its preparations are ginkgo flavonoids and terpene lactones, which have been widely used in the clinical treatment of coronary heart disease and hyperlipidemia. In addition to the above two components that have been developed as medicines in Ginkgo biloba, there is another compound polyprenol (PolyprenolsGP) with a wide range of biological activities. [0003] Ginkgo biloba polyprenols (polyprenols) are linear oligomers composed of 14 to 23 isopentene units, which are another class of substances with important physiological activities after ginkgo flavonoids and terpene lactones. Studies have show...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/765A61K36/16A61K9/00A61P17/02
Inventor 李海涛王成章周春祥
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE