Enteric coated Chinese medicinal capsule for treating cancer and preparation method thereof

A technology for enteric-coated capsules and capsules, which is applied in the directions of capsule delivery, medical preparations containing active ingredients, and drug combinations, can solve the problems of aggravating the condition of patients with gastric diseases, aggravating the condition of patients, and strong irritation, and achieves the reduction of adverse effects. The effect of reaction, elimination of toxic and side effects, and symptom relief

Active Publication Date: 2009-05-27
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The capsules prepared in this way have been shown by clinical experiments and toxicological studies to produce strong irritation to the esophagus and stomach, causing nausea, vomiting and other discomforts after taking it, and inducing or aggravating the condition of patients with stomach problems
The main active ingredient, cantharidin, is strongly irritating to the esophagus and gastrointestinal tract after oral administration, so the preparation cannot be used for cancer patients with relatively low immunity and gastric cancer patients who have undergone radiotherapy and chemotherapy, and the patients have loss of appetite and severe vomiting. , exacerbating the condition of patients with a history of gastric disease

Method used

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  • Enteric coated Chinese medicinal capsule for treating cancer and preparation method thereof
  • Enteric coated Chinese medicinal capsule for treating cancer and preparation method thereof
  • Enteric coated Chinese medicinal capsule for treating cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] [Example 1] Get Mylabris 23.8g, Ginseng 59.5g, Radix Astragali 297.5g, Acanthopanax 297.5g, Triangle 95g, Scutellaria barbata 357g, Curcuma 95g, Cornus officinalis 119g, Ligustrum lucidum 119g, bear bile powder 2.4g, Licorice 59.5g, except bear bile powder, ginseng, dogwood, Ligustrum lucidum, Scutellaria barbata, crushed into fine powder, sieved for later use; Mylabris was soaked in chloroform for 3 times, 95.2ml each time, soaked for 72 hours, and the extracts were combined , recovered chloroform, concentrated to a thick paste, and set aside; the other five flavors such as Astragalus were decocted in water three times, the first time was 3 hours, the second time was 1.5 hours, the third time was 1 hour, the decoction was combined, filtered, and the filtrate was concentrated to relative The density is about 1.20 (80°C); after the bear bile powder is dissolved in 80°C water, add the above-mentioned thick pastes and fine powders such as ginseng, etc., stir well, dry below...

Embodiment 2

[0044] [Example 2] Get Mylabris 47.6g, Ginseng 119g, Radix Astragali 595g, Acanthopanax 595g, Sanleng 190g, Scutellaria Scutellariae 714g, Curcuma 190g, Cornus officinalis 238g, Ligustrum lucidum 138g, Bear bile powder 4.8g, Radix Glycyrrhizae 119g, In addition to bear bile powder, ginseng, dogwood, Ligustrum lucidum, and Scutellaria barbata were crushed into fine powder, and sieved for later use; Mylabris was extracted by soaking 190.4ml in chloroform three times, soaking for 72 hours, combining the extracts, recovering chloroform, Concentrate to a thick paste and set aside; the other five flavors such as astragalus are decocted three times with water, the first time is 3 hours, the second time is 1.5 hours, and the third time is 1 hour, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of about 1.20 (80°C); after the bear bile powder is dissolved in 80°C water, add the above-mentioned thick pastes and fine powders such as ginseng, sti...

Embodiment 3

[0045] [Example 3] Get Mylabris 11.9g, Ginseng 29.75g, Astragalus 148.75g, Acanthopanax 148.75g, Trigonum 47.5g, Scutellaria barbata 178.5g, Curcuma 47.5g, Cornus officinalis 59.5g, Ligustrum lucidum 34.5g, bear Gallbladder powder 1.2g, licorice 29.75g, in addition to bear gallbladder powder, ginseng, dogwood, privet fruit, Scutellaria barbata, crushed into fine powder, sieved for later use; mylabris soaked in chloroform for 3 times, 47.6ml each time, soaked for 72 hours, combine the extracts, recover chloroform, concentrate to a thick paste, and set aside; add water and decoct the remaining five flavors such as Astragalus membranaceus for three times, the first time for 3 hours, the second time for 1.5 hours, the third time for 1 hour, combine the decoctions, and filter , the filtrate is concentrated to a relative density of about 1.20 (80°C); after the bear bile powder is dissolved in 80°C water, add the above-mentioned thick pastes and fine powders such as ginseng, stir well...

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PUM

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Abstract

The invention relates to Chinese medicinal enteric-soluble capsules for treating cancer and the process for preparation, wherein the preparation is prepared from raw materials including cantharis, ginseng, astragalus root, acanthopanax root, burred tuber, barbat skullcap, zedoary, cornus officinalis, ligustrum japonicum, bear's gall powder and licorice root.

Description

technical field [0001] The invention relates to a traditional Chinese medicine enteric-coated capsule for treating cancer and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] The incidence and mortality of cancer are increasing year by year, which seriously threatens human health and has become one of the main causes of human death. Western medicine treatment is mainly based on surgery, radiotherapy, and chemotherapy. However, chemotherapy or radiotherapy often causes nausea, loss of appetite, changes in blood images, and impairment of immune function. While cancer cells are inhibited or partially killed, the human body is normal. Tissue cells are correspondingly greatly destroyed and damaged, so many patients cannot persist in completing the course of radiotherapy and chemotherapy, and lose the chance of effective treatment. However, traditional Chinese medicine believes that the main causes of c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/906A61K36/902A61K36/539A61K36/484A61K36/481A61K36/40A61K36/258A61K36/254A61K36/185A61K35/64A61K35/413A61P35/00
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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