Compound cantharis liquid formulation and preparation method thereof
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A technology of liquid preparation and mylabris, applied in the field of compound mylabris liquid preparation and its preparation, can solve the problems of incomplete absorption, slow onset of action, low bioavailability, etc., and achieve low production cost, good stability, and high bioavailability Effect
Active Publication Date: 2009-02-04
GUIZHOU YIBAI PHARMA CO LTD
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Problems solved by technology
The route of administration is oral, and the oral preparation is absorbed into the systemic circulation through the gastrointestinal tract to exert its curative effect, which has the disadvantages of slow onset of action, incomplete absorption, and low bioavailability; at the same time, the application of oral preparations has certain advantages for patients who are inconvenient to take orally. limitation
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Embodiment 3
[0063] Example 3 of the present invention: Mylabris 6g, Ginseng 15g, Radix Astragali 100g, Acanthopanax 100g, Sanleng 24g, Scutellaria barbata 100g, Curcuma 24g, Cornus officinalis 30g, Ligustrum lucidum 30g, bear bile powder 1.0g, licorice 15g
[0064] The preparation method is: the eleven flavors in the recipe, except the bear bile powder, the mylabris is crushed into a 50-mesh coarse powder, add 25 times the amount of water, soak for 50 minutes, extract 3 times with water, and add 15 times the amount each time from the second time water, extract for 1.5 hours, filter, combine the filtrate, add ethanol until the alcohol content reaches 80%, stand still, filter, the filtrate is concentrated under reduced pressure into a thick paste, add 10 times the amount of water, stir, stand still, filter, The filtrate was centrifuged at a speed above 10,000 rpm for 25 minutes, the centrifugate was concentrated under reduced pressure, dried, and pulverized for later use;
[0065] Take the ...
Embodiment 6
[0077] According to the prescription and method of Example 2, the mylabris extract, total saponin extract and polysaccharide active components were prepared.
[0078] Dissolve the above-mentioned mylabris extract, total saponin extract, and polysaccharide active components with water for injection, then add bear bile powder to dissolve, add dextran, adjust the pH value to 4.5, filter through a 0.22 μm microporous membrane, freeze-dry, and prepare Become 1000 sticks of freeze-dried powder injection.
Embodiment 7
[0080] According to the prescription and method of Example 4, the mylabris extract, total saponin extract and polysaccharide active components were prepared.
[0081] Dissolve the above-mentioned mylabris extract, total saponin extract, and polysaccharide active components with water for injection, then add bear bile powder to dissolve, add dextran and polyvinylpyrrolidone, adjust the pH value to 4.3, and use a 0.22 μm micropore Filter through a filter membrane, freeze-dry, and prepare 1,000 freeze-dried powder injections.
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Abstract
The invention discloses a compound cantharis liquid preparation and a preparation method thereof, and the compound cantharis liquid preparation is prepared by cantharis, ginseng, radix astragali, acanthopanax, sparganium, herba scutellariae barbatae, rhizoma zedoariae, common macrocarpium fruit, glossy privet fruit, bear bile powder, liquorice and appropriate auxiliary materials. The invention adopts the methods of water extraction, ethanol depositing and centrifugation to extract, the extraction yield is high, water extract liquid is uniform, the stability is good, no residual solvent exist, and the production cost is lower; the rest nine drug ingredients except the bear bile powder and the cantharis are extracted by adopting the method of water decoction; meanwhile, the active ingredient of total saponin extracted from the nine drug ingredients is purified by using macroporous resin column, so that the purity quotient reaches over 55%; the extracted amyloses is purified by adopting the method of ethanol depositing for a plurality of times or hollow fiber column ultrafiltration. The preparation method combines the traditional Chinese medicine and advanced preparation technique, applies the modern scientific method and is on the basis of various scientific and clinical experiments and studies, as well as the summary of a great deal of documents and materials; the obtained compound cantharis oral preparation has high bioavailability and more remarkable drug action.
Description
Technical field: [0001] The invention relates to a compound mylabris liquid preparation and a preparation method thereof, belonging to the technical field of traditional Chinese medicine pharmacy. Background technique: [0002] The compound mylabris preparation is a medicine that has the effects of breaking blood, reducing weight, and attacking toxin and eroding sores. Among them, Fufang Mylabris Capsule is a variety recorded in the 17th volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health". The prescription is composed of 11 medicines including Mylabris, Ginseng, Astragalus, Acanthopanax, Sanleng, Scutellaria barbata, Curcuma, Cornus officinalis, Ligustrum lucidum, bear bile powder, and licorice. One of the better drugs for , malignant lymphoma, gynecological malignancies, etc. In recent years, the incidence of lung cancer, primary liver cancer, colorectal cancer, and gynecological malignant tumors has increased year by year...
Claims
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