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Composition for matching with contact lenses and its application

A contact lens and composition technology, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of not taking into account the damage, cumbersome use, etc., to prolong the time of wearing lenses, improve Effect of comfort and safety, good health protection function

Active Publication Date: 2009-07-15
上海卫康光学眼镜有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also eye drops that are used in conjunction with contact lenses to add ingredients that nourish the eyes, such as the eye-moisturizing solution disclosed in the Chinese patent CN1215588A, but it does not take into account the possibility caused by the embedded effect of its nutritional ingredients and bactericide on the surface of the lens damage, and it is cumbersome to use in order to stabilize the entire system

Method used

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  • Composition for matching with contact lenses and its application
  • Composition for matching with contact lenses and its application
  • Composition for matching with contact lenses and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]

[0033]

[0034] * DBC is dodecyl dimethyl benzyl ammonium chloride.

[0035] First heat the water to above 60°C, then add HPMC and EDTA-2Na evenly under stirring state, cool to 30°C after completely dissolving, add buffer and tension regulator, wait for the water temperature to drop below 20°C, then add polyalkane Glycine, inosine and VB6 are all dissolved and then added into the bactericide, the pH value and osmotic pressure value of the solution are measured, and finally put into a sterile eye drop bottle for preservation after sterilization and filtration.

[0036] The reagents used in the composition are commercially available common reagents, the osmotic pressure of solutions A to G is 278 to 316 mOsm / kg H2O, and the pH value is 6.85 to 7.55.

Embodiment 2

[0037] Embodiment 2 Performance detection of the composition of the present invention

[0038] For detecting the safety of solution, utilize the measuring method mentioned in ISO9363-1, measure the cytotoxicity of above-mentioned 7 solutions, find that the growth of cell in 7 solutions is all better than negative control (isotonic saline), cell proliferation degree The values ​​measured by the method are all grade 0 (grade 0 is the best, and the degree of proliferation is >75%, grade 4 is the worst, and the degree of proliferation is <25%, and it is generally judged that grade 1 or above is a non-irritating liquid), which means that the 7 solutions The safety is relatively good, but the data also shows that the nutrients inosine, polyalkylglycine and VB6 in the solution have a huge positive impact on cell growth when the three are used in combination, while the effect of the two phases combined or used alone Both are slightly worse, and the specific results can be found in Tab...

Embodiment 3

[0045] Embodiment 3 Composition comfort detection of the present invention

[0046] A drop test was carried out on solutions A, C, D, and E. Randomly select 50 volunteers with no eye diseases and no history of eye drops as group 1, and 50 volunteers who have been wearing contact lenses for more than 2 years as group 2, and use normal saline as a control for test drops. The volunteers who instilled eye drops for the first time felt that there was no foreign body sensation at the moment of instilling the eye lotion. After instilling, they felt that the eyes were continuously moist and comfortable, which could properly relieve visual fatigue; while the volunteers who wore contact lenses The subjective feeling is that the vision is clearer, the feeling of dry eyes is relieved, the positioning of the lens on the surface of the eyeball is better, and there is no discomfort after wearing it continuously for more than 8 hours. See Table 2 for details.

[0047] Table 2 The test drop ...

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Abstract

The invention relates to a composition used with contact lenses and its application. The composition is an eye drop containing polymerized amino acid, inosine and VB6, which can not only lubricate contact lenses, keep eyes moist, but also properly protect eyes, improve the comfort of glasses and prolong the time of glasses. There is no need to remove the contact lens during use, and it can be directly instilled into the eye, and can be instilled in an unlimited amount every day without causing the problem of accumulation and embedding of the composition on the lens.

Description

technical field [0001] The invention relates to an eye drop composition capable of lubricating contact lenses and properly protecting eyes and its application. Background technique [0002] Contact lenses that are widely used today can be divided into two categories according to their raw materials, one is hard lenses with methyl methacrylate as the main raw material; the other is hydraulic lens with hydroxyethyl methacrylate as the main raw material. Rubber or soft lenses. Due to poor deformation characteristics of hard lenses, the foreign body sensation in the eyes is strong, and the adaptability to initial wear is poor. Consumers prefer to choose hydrogel or soft lenses with good deformation characteristics and comfortable wearing. The contact lenses mentioned in the present invention specifically refer to hydrogel or soft lenses. [0003] As a substitute for frame glasses, contact lenses are used to correct vision and some eye defects. Because of their advantages of ea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/785A61K31/4415A61K31/708A61P27/02
Inventor 徐新晨刘朝恒
Owner 上海卫康光学眼镜有限公司
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