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Composition for matching with contact lenses and its application

A technology for contact lenses and compositions, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of not taking into account the damage and the cumbersome use methods, and can prolong the wearing time of lenses, improve the The effect of comfort and safety, good health protection function

Active Publication Date: 2006-11-08
上海卫康光学眼镜有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are also eye drops that are used in conjunction with contact lenses to add ingredients that nourish the eyes, such as the eye-moisturizing solution disclosed in the Chinese patent CN1215588A, but it does not take into account the possibility caused by the embedded effect of its nutritional ingredients and bactericide on the surface of the lens damage, and it is cumbersome to use in order to stabilize the entire system

Method used

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  • Composition for matching with contact lenses and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0036] Embodiment 2 Performance detection of the composition of the present invention

[0037] For detecting the safety of solution, utilize the measuring method mentioned in ISO9363-1, measure the cytotoxicity of above-mentioned 7 solutions, find that the growth of cell in 7 solutions is all better than negative control (isotonic saline), cell proliferation degree The values ​​measured by the method are all grade 0 (grade 0 is the best, and the degree of proliferation is > 75%, grade 4 is the worst, and the degree of proliferation is < 25%, and it is generally judged that grade 1 or above is a non-irritating liquid), which means that the 7 solutions The safety is relatively good, but the data also shows that the nutrients inosine, polyalkylglycine and VB6 in the solution have a huge positive impact on cell growth when the three are used in combination, while the effect of the two phases combined or used alone Both are slightly worse, and the specific results can be found in T...

Embodiment 3

[0042] Embodiment 3 Composition comfort detection of the present invention

[0043] A drop test was carried out on solutions A, C, D, and E. Randomly select 50 volunteers with no eye diseases and no history of eye drops as group 1, and 50 volunteers who have been wearing contact lenses for more than 2 years as group 2, and use normal saline as a control for test drops. The volunteers who instilled eye drops for the first time felt that there was no foreign body sensation at the moment of instilling the eye lotion. After instilling, they felt that the eyes were continuously moist and comfortable, which could properly relieve visual fatigue; while the volunteers who wore contact lenses The subjective feeling is that the vision is clearer, the feeling of dry eyes is relieved, the positioning of the lens on the surface of the eyeball is better, and there is no discomfort after wearing it continuously for more than 8 hours. See Table 2 for details.

[0044] Solution A ...

Embodiment 4

[0050] Example 4 Observation of eye drops remaining on the lens

[0051] The eye drops are directly dripped into the eyes, but most of them will be washed away by tears after two blinks, but the various components contained in them will still remain on the surface of the lens after multiple drops. Soak the lens in each solution for 24 Take it out after an hour, observe the lens surface under a slit lamp, observe the section at the lens gap under a high-power microscope (500 times), the result shows that the composition of the present invention has less residual substances on the lens surface and the lens gap, specifically See Table 3.

[0052] Slit lamp observation of lens surface

[0053] Note: "-" means no observed or no variation, "+" means observed or variation. Eye drops I is commercial eye drops for ordinary contact lenses, and eye drops II is commercial eye drops, which are rich in ingredients such as taurine, VB6 and hydrolyzed pearl liquid.

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Abstract

The present invention relates to a kind of composition for use matching with contact lenses and its application. The composition contains amino acid polymer, inosine and vitamin B6 eye drop, and can lubricate contact lenses and eyes, protect eyes and make wearing of contact lenses comfortable. It is dropped into eyes while the contact lenses are in.

Description

technical field [0001] The invention relates to an eye drop composition capable of lubricating contact lenses and properly protecting eyes and its application. Background technique [0002] Contact lenses that are widely used today can be divided into two categories according to their raw materials, one is hard lenses with methyl methacrylate as the main raw material; the other is hydraulic lens with hydroxyethyl methacrylate as the main raw material. Rubber or soft lenses. Due to poor deformation characteristics of hard lenses, the foreign body sensation in the eyes is strong, and the adaptability to initial wear is poor. Consumers prefer to choose hydrogel or soft lenses with good deformation characteristics and comfortable wearing. The contact lenses mentioned in the present invention specifically refer to hydrogel or soft lenses. [0003] As a substitute for frame glasses, contact lenses are used to correct vision and some eye defects. Because of their advantages of ea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/785A61K31/4415A61K31/708A61P27/02
Inventor 徐新晨刘朝恒
Owner 上海卫康光学眼镜有限公司
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