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Blood flow estimate through replenishment curve fitting in ultrasound contrast imaging

A contrast agent, ultrasonic pulse technology, applied in the field of blood flow estimation technology, can solve problems such as estimation that is not suitable for absolute quantification of flow parameters

Active Publication Date: 2009-07-22
BRACCO SUISSE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Extracted parameters are also specific to each instrument type, making comparisons between researchers using different equipment or setups impossible
Furthermore, the perfusion parameters extracted from the prior art are only relative estimates and are not suitable for the estimation of absolute quantification of flow parameters

Method used

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  • Blood flow estimate through replenishment curve fitting in ultrasound contrast imaging
  • Blood flow estimate through replenishment curve fitting in ultrasound contrast imaging
  • Blood flow estimate through replenishment curve fitting in ultrasound contrast imaging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0082] In the following description, the symbols used are defined as follows:

[0083] x

The spatial coordinates in the image plane, the (horizontal) direction orthogonal to the beam

y

Spatial coordinates on the image plane, orthogonal (perpendicular) to the beam

z

Spatial coordinates in the image plane, along the (depth) direction of the beam

D

Spatial extent of microbubble disruption in the vertical (y) direction

F

ultrasonic frequency

c

speed of sound

A

Ultrasonic length

m

mean of natural logarithms

s

Standard Deviation of Natural Logarithm

mu

mean of the lognormal distribution

σ 2

Variance of lognormal distribution

gamma

Skewness of the lognormal distribution

τ

Flow transit time from the edge of the damaged area to the center

τmean

mean value of τ

C

Probability Density or Relative Concentra...

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Abstract

Systems and methods for non-invasively quantifying tissue perfusion achievable through a disruption-replenishment process by deriving at least one local tissue perfusion value that provides a signal representative of a local agent concentration during reperfusion. The system includes means for calibrating or relating a time function having a sigmoidal characteristic to a signal proportional to the local agent concentration during reperfusion, and at least one parameter of the function having a sigmoidal characteristic A value is associated with at least one local tissue perfusion value (eg, mean velocity, mean transit time, mean flow, perfused volume) or property (eg, blood flow pattern, flow distribution variance, or slope).

Description

technical field [0001] The present invention relates to a technique for blood flow estimation during destruction / replenishment monitoring of gas-filled microbubbles, wherein the flow parameters are derived from the analysis of the kinetic characteristics of the recharge. More specifically, the present invention relates to a method of non-invasively quantifying perfusion in living tissue. The invention also relates to a computer program for carrying out the method, and to a product containing the program. Furthermore, the invention relates to a corresponding system for the non-invasive quantification of perfusion, and a device for use in this system. Background technique [0002] The use of suspensions of air bubbles in a carrier liquid as effective ultrasound reflectors is well known in the art. The development of these suspensions as a means of enhancing ultrasound imaging follows early observations that rapid injection of aqueous solutions into veins causes dissolved gas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B8/06A61K49/22
Inventor 彼得·弗林京玛索·阿迪特伊莱瑞尔·乔瑞
Owner BRACCO SUISSE SA
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