45 results about "Contrast-enhanced ultrasound" patented technology

The invention is a method of using ultrasound waves that are focused at a specific location in a medium to cause localized production of bubbles at that location and to control the production, and the cavitational and heating effects that take place there. According to the method of the invention, the production and control is accomplished by selecting the range of parameters of multiple transducers that are focused at the location such that they produce by interference specific waveforms at the focal point, which are not produced at other locations. Preferably the region within the focal zone of all the transducers in which the specific waveform develops at significant intensities, is typically very small. The invention is also a system for carrying out the method. The method and system of the invention can be used to perform a variety of therapeutic procedures. Typical of such procedures is occlusion of varicose veins.

The invention relates to an ultrasonic contrast imaging method and system. The system comprises a probe 1, a transmission circuit 2, a reception circuit 4 and a signal processing module, wherein the transmission circuit is used for respectively transmitting a first pulse sequence and a second pulse sequence to a target area through the probe; the reception circuit is used for respectively receiving ultrasonic echoes of the first pulse sequence and the second pulse sequence through the probe so as to obtain a first group of ultrasonic echo signals and a second group of ultrasonic echo signals; and the signal processing module is used for extracting echo signal components according to the first group of ultrasonic echo signals and the second group of ultrasonic echo signals. The invention furthermore discloses a new ultrasonic contrast image transmission control method, so that the registering success rate of a software analysis tool is improved.

Systems and methods for non-invasively quantifying tissue perfusion achievable through a destruction-replenishment process by deriving at least one local tissue perfusion value that provides a signal representative of a local agent concentration during reperfusion. The system includes means for calibrating or relating a time function having a sigmoidal characteristic to a signal proportional to the local agent concentration during reperfusion, and at least one parameter of the function having a sigmoidal characteristic A value is associated with at least one local tissue perfusion value (eg, mean velocity, mean transit time, mean flow, perfused volume) or property (eg, blood flow pattern, flow distribution variance, or slope).

The invention discloses a method for extracting a blood vessel perfusion region from contrast-enhanced ultrasound images based on a brox optical flow method. The method comprises the steps of (1) obtaining image frames and forming a contrast-enhanced ultrasound image sequence, (2) conducting image preprocessing to reduce speckle noise of each contrast-enhanced ultrasound image, (3) estimating a motion field of every two frames of adjacent contrast-enhanced ultrasound images based on the brox optical flow method, and correcting the two frames of adjacent contrast-enhanced ultrasound images according to an estimated deviation value, and (4) extracting points of the blood vessel perfusion region through a threshold segmentation method. The method has the advantages that the brox optical flow method which is insensitive to noise and high in robustness is adopted to estimate motion displacement of the adjacent image frames and correct the motion displacement; based on the corrected contrast-enhanced ultrasound image sequence, the perfusion region is extracted different from signal features of other tissue backgrounds according to highlight and flashing expressed by radiography microbubbles in blood; experiment results show that the method is small in calculated quantity, easy to realize and good in extraction effect when applied to clinical data.

Ultrasonic diagnostic arrangements (apparatus, methods, etc.) including: an ultrasonic probe or operation for transmitting an ultrasonic wave to an object to be tested and receiving an ultrasonic wave from the object; a transmitter or operation for pulse-driving the ultrasonic probe to transmit an ultrasonic beam to the object; a reception phasing unit or operation for performing phasing on reflected echo signals received by the ultrasonic probe, the reception phasing unit separately performing phasing at multiple phasing frequencies on the reflected echo signals received in response to at least one transmission of the ultrasonic beam; an image generator or operation for generating an ultrasonic image based on the phased received signal.

The invention provides an ultrasonic contrast imaging method. The method includes: performing feature point extraction and feature point matching according to two continuous frames of volume data to obtain a plurality of matching feature points; obtaining an affine matrix, multiplying the voxel value corresponding to each voxel point of the second volume data by the affine matrix to obtain each corresponding individual data value; subtracting the individual data value from the voxel values of the voxel points of the first volume data point by point to obtain a plurality of voxel difference values; and obtaining a difference region according to the voxel difference value, extracting the difference region of the new second volume data by using an iterative processing mode, completing the extraction of the difference region of all volume data, and filling different colors in each difference region to obtain an ultrasound contrast imaging image. According to the invention, the flow direction and process of the contrast agent can be clearly and visually displayed, and a more real contrast image can be obtained, so that a doctor can be better assisted in diagnosis. The invention furtherprovides an ultrasonic contrast imaging device, ultrasonic contrast imaging equipment and a readable storage medium which all have the above beneficial effects.

The present application discloses an ultrasound contrast imaging method comprising: transmitting an unfocused wave to a target region containing microbubbles in a plurality of directions; receiving echo signals of the unfocused wave; and selecting an echo signal corresponding to at least a portion of the angles in a plurality of angles from the echo signals; and generating a contrastographic picture based on the selected echo signal and displaying the same in color codes. The application also discloses an ultrasound imaging system.

The invention provides a patterning-set device and a correlation method for ultrasonic equipment to be used for providing a patterning setting scheme for imaging parameters and an imaging algorithm of an ultrasonic contrast imaging system. According to the technical scheme, the patterning-set device comprises an initializing unit, a selection prompting unit and a configuring unit, wherein the initializing unit is used for initializing the imaging parameters and the imaging algorithm according to a general pattern, the selection prompting unit is used for prompting a user to select a pattern from a pattern set to serve as a preference pattern, the configuring unit is used for configuring the imaging parameters and the imaging algorithm according to the preference pattern, and patterns in the pattern set comprise configuring modes of the imaging parameters and the imaging algorithm. By means of the technical scheme, the operating efficiency of a user can be improved, and meanwhile the diagnosing effect of ultrasonic contrast imaging can be improved.

The invention relates to a novel ultrasonic / magnetic resonance dual-mode contrast agent and a preparation method and an application thereof; the contrast agent is a coordination polymer nanoparticle contrast agent with the surface modified by polyvinylpyrrolidone; the interior of the coordination polymer nanoparticle contrast agent has a cavity structure, the coordination polymer nanoparticle contrast agent is also doped with rare earth elements Ir and Ho. The preparation method comprises the steps: during preparation, preparing a DMSO solution of a 2-phenylquinoline 3,3'-iridium dipyridine dicarboxylate complex, adding polyvinylpyrrolidone, stirring and mixing evenly, heating up to 30-200 DEG C, keeping constant temperature for 0.1-2 h, then adding a DMSO solution of holmium acetate, carrying out a reaction for 0.1-48 h, after the reaction is finished, dialyzing for 10-12 h with deionized water, and centrifuging. The prepared dual-mode contrast agent is used in ultrasound contrast imaging and magnetic resonance contrast imaging. Compared with the prior art, the dual-mode contrast agent has the advantages of uniform morphology, good dispersion, excellent stability, simple synthetic process, easily obtained raw materials, no pollution to the environment, and quite good application prospects.

A method for improving the definition of ultrasonic image features that after a low mechanical index is used for scanning, the low mechanical index is regulated to high mechanical index. An ultrasonic imaging method features that after a low mechanical index is used to scan for finishing the ultrasonic image, the contrast medium micro-bubble residual in the tissue and a high mechanical index are used for instantaneous ultrasonic imaging to obtain high-definition image of tissue. An ultrasonic imaging method for diagnosing tumor with high correctness is also disclosed.

The invention provides a method for automatically removing an ultrasound contrast imaging non-contrast region. The method comprises the following steps: collecting N rolls of ultrasound contrast imaging data in a filling process of a contrast agent, wherein N is greater than or equal to 2; setting a grey value difference threshold T of two adjacent rolls of ultrasound contrast imaging data; solving a grey value difference between every two adjacent rolls of ultrasound contrast imaging data at all the same positions in the N rolls of ultrasound contrast imaging data; comparing the solved grey value difference with the threshold T, setting a point where the grey value difference is greater than the threshold T as a contrast imaging region, estimating a background region by solving a complementary set of N rolls of contrast imaging region union sets, and removing the background region. The invention also provides a corresponding device and corresponding equipment. By the adoption of the method, the device and the equipment, the background region is estimated according to the grey value difference between every two adjacent rolls of data at the same positions in the filling process of the contrast agent and is removed for each roll of data of an ultrasound image, so that the operation trouble of manually removing the background region by a doctor in ultrasound contrast imaging is eliminated.

The invention discloses an ultrasonic contrast method and device and a storage medium. The method comprises the steps: obtaining a plurality of multi-pulse signals which are ultrasonic echo signals passing through a target region containing an ultrasonic contrast agent, and enabling every two adjacent multi-pulse signals to be spaced by one pulse repetition period; carrying out subtraction processing on the multiple multi-pulse signals to eliminate noise signals in the multi-pulse signals to obtain processed signals; and generating an ultrasound contrast image by using the processed signals, wherein in a pulse repetition period, the harmonic noise generated by the tissue background and the ultrasonic system is basically unchanged, the change is mainly concentrated on the ultrasonic contrast agent, the inhibition of the harmonic noise of the tissue background and / or the ultrasonic system can be better completed through subtraction, and the effect of ultrasonic contrast imaging is improved.

The invention provides an ultrasound contrast imaging method and apparatus. The method comprises: S1. transmitting a plurality of pulse waveform sequences, and acquiring echo signals of various pulses; S2. processing echoes of the various pulses to extract non-linear components of the echoes, and acquiring amplitude information about the non-linear components; S3. selecting echoes of any one or more pulses for processing to extract linear components of the echoes, and acquiring amplitude information about the linear components; S4. using the amplitude information about the non-linear components and that of the linear components to generate a non-linear parameter; and S5. performing imaging processing on the non-linear parameter. In the method, by simultaneously using amplitude information about linear components and non-linear components of an echo to generate a non-linear parameter, and performing imaging after processing this parameter, tissue residues can be effectively inhibited, and the dynamic range of a contrast agent signal is increased, thereby improving the CTR and contrast resolution of a contrast image.

The invention discloses an ultrasound contrast imaging adjustment method, system and device and a computer medium. The method comprises the steps: acquiring an imaging frame rate and real-time imagingdepth of a target ultrasound contrast device in the ultrasound contrast process, adjusting an emission time sequence of the target ultrasound contrast equipment based on the imaging frame rate, adjusting the real-time transmitting frequency of the target ultrasound contrast equipment based on the real-time imaging depth, acquiring radio frequency signal data of the target ultrasound contrast equipment in an ultrasound contrast process, adjusting real-time receiving demodulation parameters of the target ultrasound contrast equipment based on the radio frequency signal data, and performing ultrasonic contrast imaging again based on the adjusted target ultrasonic contrast equipment to obtain a target ultrasonic contrast image. According to the method and the device, multiple parameters of the target ultrasound contrast equipment are adjusted, the adjusted target ultrasound contrast equipment is more consistent with the actual operation condition, and the adjusting effect is good.

The invention provides a method for ultrasonography, an image storage method for ultrasonography and ultrasonography equipment. The method for ultrasonography comprises the steps: transmitting first ultrasonic waves to inspected tissue, so as to determine a target area; transmitting second ultrasonic waves to the contrast-microbubble-containing target area when the target area contains contrast microbubbles, so as to obtain an ultrasonic image at least comprising contrast images; receiving a first instruction for storing dynamic images of the ultrasonic image; and storing the dynamic images inresponse to the first instruction. The method further comprises the steps: when the dynamic images are stored, receiving a second instruction for storing one-frame or multi-frame static images and / ordynamic short films in the dynamic images; and storing the one-frame or multi-frame static images and / or dynamic short films in response to the second instruction. According to the methods and the equipment, the complexity and difficulty of inspection operations of doctors can be lowered, and the working efficiency is increased.

The invention provides an ultrasonic contrast imaging method and device. The method comprises the steps that a first ultrasonic probe is controlled to emit first ultrasonic waves to a liver area of a target object; a first ultrasonic image is generated based on a first ultrasonic echo signal, and an area of interest on the first ultrasonic image is acquired to determine a position area to be subjected to contrast imaging in the liver area; under the condition that a contrast agent is injected into the target object, the first ultrasonic probe is controlled to emit second ultrasonic waves to the position area; after the contrast agent is injected and when preset conditions are met, a second ultrasonic probe is controlled to emit third ultrasonic waves to a portal vein area of the liver area, wherein the third ultrasonic waves are used for bursting microbubbles generated by the contrast agent in the portal vein, and emission of the second ultrasonic waves and emission of the third ultrasonic waves are conducted alternately or conducted independently; and a contrast image is generated based on a second ultrasonic echo signal. According to the method and device, pure hepatic artery ultrasonic contrast imaging can be achieved.

The invention discloses a preparation method of a dabrafenib-loaded lipid nano-microbubble ultrasonic contrast agent. The preparation method comprises the following steps, step 1, establishing covalent connection between dabrafenib and DSPE-PEG2000-COOH by EDC-NHS amide reaction method to synthesize DSPE-PEG2000-Dabrafenib; step 2, preparing a lipid suspension by membrane hydration method; and step 3, preparing the high-concentration lipid nano-microbubble ultrasonic contrast agent by mechanical oscillation method. Inert gas C3F8 constitutes a core, so that the nano-microbubble has good stability. The DSPE-PEG2000-Dabrafenib is used as a main component of a lipid nano-microbubble shell membrane to realize the effective and reliable connection between Dabrafenib and nano-microbubble. According to the present invention, one-stop contrast-enhanced ultrasonograhy and precise treatment on BRAFV600E gene mutant tumors is achieved.

The invention is suitable for the technical field of ultrasonic contrast imaging, and provides a signal processing system and method based on the ultrasonic contrast imaging technology and terminal equipment. The system comprises a signal acquisition module and a signal processing module; the signal acquisition module is used for transmitting pulse waves, receiving the corresponding echo signals and sending same to the signal processing module; the signal processing module is used for extracting target frequency signals in the echo signals, obtaining the amplitude of the target frequency signals through calculation according to the target frequency signals, performing denoising processing on the amplitude of the target frequency signals through a Kalman filter, and obtaining the amplitude of the denoised target frequency signal. Noise signal interference is overcome, and the processing efficiency of the amplitude of the target frequency signal and the precision of the processing result are improved.

An ultrasound imaging device, a system and an image enhancement method for contrast-enhanced ultrasound imaging thereof. Because the image enhancement coefficients of each position point in the detected biological tissue are first calculated according to the contrast channel data, and then the image enhancement coefficients and the beamforming data are weighted.

A method, system and ultrasound contrast imaging equipment for enhancing ultrasound contrast images. Based on nonlinear contrast information and linear tissue information obtained from ultrasound echo signals, nonlinear parameters are calculated to obtain nonlinear parameter distribution diagrams, respectively. The bipolar threshold divides the nonlinear parameter distribution map. Each division separates the contrast agent area and the tissue residual area. The contrast agent area is enhanced and the tissue residual area is suppressed, so that the area that absolutely belongs to the contrast agent can be processed. Enhance to a large extent, suppress areas that are definitely tissue residues to a large extent, enhance and suppress areas between contrast agents and tissue residues to a slightly weaker degree, and finally combine the results after two classifications and weight adjustments. Fusion processing enables the enhancement of contrast agents, suppression of contrast agents, and conservative treatment of residues between contrast agents and tissues to achieve ideal contrast image enhancement effects.

An embodiment of the invention provides a method, a device and equipment for identifying flow directions of contrast agents. When contrast examination is performed, an ultrasonic contrast image of anarea of interest is acquired in an ultrasonic contrast examination state. The ultrasonic contrast image is analyzed, and the flow directions of the contrast agents in the ultrasonic contrast image areacquired. Each flow direction of the contrast agents is identified. Therefore, the contrast agents in different flow directions are identified in different modes, ultrasonic contrast imaging accuracyis improved, and ultrasonic contrast diagnosis of a doctor is facilitated by identifying the flow directions of the contrast agents.

An ultrasound contrast imaging method and device, and a storage medium. The method comprises: acquiring at least two frames of contrast data (S310); calculating an information difference between two adjacent frames of contrast data, and calculating a relationship between the information difference and one frame of contrast data in the two adjacent frames of contrast data (S320); and classifying the one frame of contrast data based on the relationship, and performing suppression processing on at least partial data of the one frame of contrast data based on the classification result (S330). According to the method, the difference between the tissue residue and the contrast agent signal is mined from the angle of time domain difference (inter-frame difference), and the tissue residue part and the contrast agent signal part in the contrast data can be effectively distinguished, so that the tissue residue part can be effectively inhibited, and the intensity of the contrast agent is not influenced as far as possible.

The present application discloses a contrast-enhanced ultrasound imaging method, including: sending at least one combination of excitation pulse sequences including multiple sets of excitation pulse sequences to an ultrasonic transmitting circuit; wherein, in each combination of excitation pulse sequences, the pulses of each group of excitation pulse sequences The amplitudes are not exactly the same; obtain the echo signals corresponding to each group of excitation pulse sequences; respectively calculate the characteristic values ​​of the contrast tissue ratio of each group of echo signals; the excitation pulse sequence corresponding to the characteristic value with the smallest difference from the preset ideal value determining the optimal excitation pulse sequence; sending the optimal excitation pulse sequence to the ultrasonic transmitting circuit, so as to generate image data based on the echo signal of the optimal excitation pulse sequence. The present application can effectively ensure the image quality of contrast-enhanced ultrasound imaging for any imaging target, greatly improving applicability and flexibility. The present application also discloses an ultrasound contrast imaging system, a control device, and a computer-readable storage medium, which also have the above beneficial effects.

The invention provides a ultrasonic contrast imaging method and ultrasonic imaging device for a fallopian tube and a storage medium. The method comprises the following steps: acquiring four-dimensional contrast data and four-dimensional tissue data of a fallopian tube area of a target object; respectively acquiring three-dimensional radiography data and three-dimensional tissue data at at least one moment from the four-dimensional radiography data and the four-dimensional tissue data; rendering the acquired three-dimensional radiography data and the three-dimensional tissue data at each moment, and fusing rendering results obtained after rendering the three-dimensional radiography data and the three-dimensional tissue data at the same moment to obtain a mixed rendered image; performing feature extraction on the mixed rendering image, and outputting an analysis result of the fallopian tube region based on a feature extraction result; and displaying the mixed rendered image and the analysis result. According to the oviduct ultrasound contrast imaging method and device, a user can understand and observe the spatial position relation and the flowing condition of the contrast agent in the tissue more visually.