3 results about "Tissue residue" patented technology

This invention belongs to the field of ecological risk assessment, specifically relating to a method for assessing the ecological risk of heavy metals in sediments based on the heavy metal tissue residues of benthic organisms. The method includes the following steps: (1) extracting and testing the total amount and occurrence forms of heavy metals in surface sediment samples from the target watershed, and effectively indicative of their presence in organisms. i Heavy metal content C i (2) Construct the first sediment in the target watershed. i Biosafety thresholds for heavy metals as effective indicator organisms P i (3) Based on the improved single-factor tissue residue index (TI) and the comprehensive tissue residue index N TI This invention classifies the ecological risks of a single heavy metal element in sediments to a target watershed, as well as the combined ecological risks of multiple heavy metal elements to the target watershed. This invention will provide important reference and basis for assessing the effectiveness of existing remediation measures and for developing scientific plans for the remediation of heavy metal pollution in sediments.

This invention discloses a compound, a chelate, a method for preparing the same, and its application in the preparation of magnetic resonance imaging contrast agents, belonging to the field of medical imaging technology. Specifically, this invention discloses a compound as shown in formula (I) or its stereoisomers, pharmaceutically acceptable salts, or mixtures thereof, which can significantly increase plasma exposure, has high bioavailability, and can prolong the in vivo imaging time window, possessing the advantages of long-acting, low-dose imaging; it also has good clearance properties and a low risk of tissue residue, thereby reducing free Gd. 3+ This approach aims to eliminate potential risks and provide a long-lasting, low-dose, and highly safe magnetic resonance imaging (MRI) contrast solution for clinical use.

This application relates to the field of biological sample processing technology, specifically disclosing a method for in-situ lysis of tissue sections. The method involves placing paraffin-embedded tissue sections on a glass slide for dewaxing; attaching a negative pressure adsorption device carrying lysis buffer to the glass slide, bringing the lysis buffer into contact with the tissue sections; adjusting the internal pressure of the negative pressure adsorption device to a negative pressure, causing the device to adhere to the surface of the glass slide, thus obtaining a negative pressure incubation component; and incubating the negative pressure incubation component to obtain tissue lysis buffer. The method for in-situ lysis of paraffin-embedded tissue sections under negative pressure provided by this invention can efficiently extract tissue sections from glass slides, reduce tissue residue, and achieve high tissue retention, DNA yield, and integrity. It also effectively avoids tissue contamination, solving the technical problems of easy cross-contamination of sections, low tissue retention, and poor DNA quality and integrity in existing tissue separation methods.