7 results about "Tissue residue" patented technology

The invention relates to the technical field of environmental toxicology and ecological risk assessment, in particular to a system and a method for predicting chronic toxicity of bioaccumulation pollutants, and the system comprises a data acquisition and processing module, a model training and optimization module, a toxicity prediction module and an ecological risk assessment module. According to the method, full-process prediction is realized through data standardization, feature engineering, model training and model prediction; tissue residual toxicity data is obtained and standardized, a multi-dimensional characteristic matrix containing pollutant physicochemical properties, species biological characteristics and experimental conditions is constructed, a toxicity prediction model is optimized by using a machine learning algorithm, and tissue residual toxicity prediction of fishes in different life stages is realized. And calculating a risk quotient based on the predicted value, and generating a risk assessment report. The problems that an existing system depends on water body concentration toxicity data, is lack of biological accumulation pollutant chronic toxicity prediction capacity and does not aim at an endangered characteristic optimization model are solved.

The invention belongs to the field of ecological risk assessment, and particularly relates to an ecological risk assessment method for heavy metal in sediment based on benthic organism heavy metal tissue residues. The method comprises the following steps: (1) extracting and testing the total amount of heavy metals and the occurrence form of the heavy metals in a surface sediment sample of a target drainage basin, and measuring the content Ci of the ith heavy metal in an effective indication organism; (2) constructing a biological residue safety threshold Pi of the ith heavy metal in the sediment of the target drainage basin for the effective indicator organism; and (3) based on the improved single-factor tissue residual index TI and the comprehensive tissue residual index NTI, dividing the ecological risk of a single heavy metal element to the target drainage basin and the comprehensive ecological risk level of multiple heavy metal elements to the target drainage basin in the sediment. Important reference and basis are provided for evaluating the implementation effect of developed treatment measures and formulating scientific sediment heavy metal pollution treatment plans in the later period.

This invention belongs to the field of ecological risk assessment, specifically relating to a method for assessing the ecological risk of heavy metals in sediments based on the heavy metal tissue residues of benthic organisms. The method includes the following steps: (1) extracting and testing the total amount and occurrence forms of heavy metals in surface sediment samples from the target watershed, and effectively indicative of their presence in organisms. i Heavy metal content C i (2) Construct the first sediment in the target watershed. i Biosafety thresholds for heavy metals as effective indicator organisms P i (3) Based on the improved single-factor tissue residue index (TI) and the comprehensive tissue residue index N TI This invention classifies the ecological risks of a single heavy metal element in sediments to a target watershed, as well as the combined ecological risks of multiple heavy metal elements to the target watershed. This invention will provide important reference and basis for assessing the effectiveness of existing remediation measures and for developing scientific plans for the remediation of heavy metal pollution in sediments.

This invention discloses a compound, a chelate, a method for preparing the same, and its application in the preparation of magnetic resonance imaging contrast agents, belonging to the field of medical imaging technology. Specifically, this invention discloses a compound as shown in formula (I) or its stereoisomers, pharmaceutically acceptable salts, or mixtures thereof, which can significantly increase plasma exposure, has high bioavailability, and can prolong the in vivo imaging time window, possessing the advantages of long-acting, low-dose imaging; it also has good clearance properties and a low risk of tissue residue, thereby reducing free Gd. 3+ This approach aims to eliminate potential risks and provide a long-lasting, low-dose, and highly safe magnetic resonance imaging (MRI) contrast solution for clinical use.

The invention relates to the technical field of sewage treatment, and provides a medical instrument cleaning sewage treatment device which comprises a sewage treatment box, and a water inlet pipe slidably penetrates through the surface of the sewage treatment box. The fragment pipe rotates under the action of the contact wheel to drive the cutting blade to rotate, the cutting blade rotates to cut up fine impurities in the fragment pipe, and meanwhile, large impurities and tissue residues are conveyed to the outside through the threaded main shaft until being discharged, so that the grading separation effect of first rough filtration and then fine treatment is achieved; the technical problems that in the prior art, when tissue residues and fibers in medical instrument cleaning sewage are treated, large-particle residues are likely to cause blockage of a filtering part, then the operation effect and efficiency of equipment are affected, and meanwhile the treatment difficulty of follow-up sewage discharging and sedimentation is affected are solved.

The present application relates to the technical field of water quality criteria prediction, and particularly relates to a rare and endangered fish water quality criteria derivation method, which comprises the following steps: conducting habitat investigation, biological investigation and pollutant investigation, and dividing water areas and pollutants; obtaining pollutant exposure data, pollutant toxicity data, test biological information and related water quality parameter data; screening the toxicity data of pollutants to different test organisms according to the principles and priority evaluation principles; using the SSD method to calculate the species hazard concentration, otherwise using the toxicity percentage ranking method to determine the final toxicity value; deriving short-term water quality criteria, long-term water quality criteria and tissue residue criteria according to the calculation results of the SSD method and the toxicity percentage ranking method. The present application can derive water quality criteria for rare and endangered fish, and provide technical support for the research of rare and endangered fish.

This application relates to the field of biological sample processing technology, specifically disclosing a method for in-situ lysis of tissue sections. The method involves placing paraffin-embedded tissue sections on a glass slide for dewaxing; attaching a negative pressure adsorption device carrying lysis buffer to the glass slide, bringing the lysis buffer into contact with the tissue sections; adjusting the internal pressure of the negative pressure adsorption device to a negative pressure, causing the device to adhere to the surface of the glass slide, thus obtaining a negative pressure incubation component; and incubating the negative pressure incubation component to obtain tissue lysis buffer. The method for in-situ lysis of paraffin-embedded tissue sections under negative pressure provided by this invention can efficiently extract tissue sections from glass slides, reduce tissue residue, and achieve high tissue retention, DNA yield, and integrity. It also effectively avoids tissue contamination, solving the technical problems of easy cross-contamination of sections, low tissue retention, and poor DNA quality and integrity in existing tissue separation methods.