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Chemotactic antibacterial nanometer material, and preparation method and application thereof

A nanomaterial and antibacterial peptide technology, applied in the field of medical and sanitary materials, can solve the problems of bacterial invasion and residue, achieve good protection, promote wound healing, and avoid invasion and infection.

Pending Publication Date: 2020-08-14
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a chemotactic antibacterial nanomaterial and its preparation method and application, which solve the problems of bacteria invading the body and bacteria and drugs remaining in the tissue

Method used

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  • Chemotactic antibacterial nanometer material, and preparation method and application thereof
  • Chemotactic antibacterial nanometer material, and preparation method and application thereof
  • Chemotactic antibacterial nanometer material, and preparation method and application thereof

Examples

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Embodiment 1

[0044] Embodiment 1, a chemotactic antibacterial nanomaterial, comprising graphene oxide and polydopamine coated on the surface of graphene oxide, the surface of the polydopamine is adsorbed with antimicrobial peptides, and the antimicrobial peptides are loaded with chemotactic The graphene oxide GO is a sheet-like structure with a sheet diameter of about 500nm, the antimicrobial peptide is gramicidin HHC-36, and the sequence is KRWWKWWRR, and the chemoattractant is L-lysine, namely L-Lysine, It is abbreviated as L-Lys for convenience of description. see figure 2 , the chemotaxis and antibacterial nanomaterials have quite strong bacterial chemotaxis properties, and can gather bacteria in a short period of time. The chemotaxis of the chemotaxis and antibacterial nanomaterials to wound bacteria presents a 3D effect, which can attract the surface layer of the wound and tissue Internal bacteria, to avoid bacterial invasion and infection. In addition, since the material does not...

Embodiment 2

[0046] Embodiment two, see figure 1, the preparation method of the chemotactic antibacterial nanomaterial described in embodiment one comprises the steps:

[0047] S1, 16 mg of dopamine hydrochloride was added to 80 mL of Tris-HCl buffer solution, shaken and mixed, the concentration of the Tris-HCl buffer solution was 10 mM, and the pH value was 8.5. Then 8 mg of graphene oxide was added, and after ultrasonic treatment for 30 minutes, the mixture was stirred and reacted on a magnetic stirrer at room temperature for 24 hours to coat polydopamine on the surface of graphene oxide. Then centrifuge at 12000 rpm for 30 min at high speed, collect the centrifuged product, wash and centrifuge the centrifuged product with ultrapure water, and repeat three times to obtain pure PDA@GO.

[0048] S2. Dissolve the PDA@GO obtained from HHC-36 and S1 in a solvent to obtain a HHC-36 solution with a concentration of 1 mg / mL and a PDA@GO solution with a concentration of 1 mg / mL. Take 1 mL of the...

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Abstract

The invention discloses a chemotactic antibacterial nanometer material which comprises graphene oxides and polydopamine coating the surfaces of the graphene oxides, wherein antibacterial peptides areadsorbed on the surface of the polydopamine; and a chemotactic agent is loaded on the antibacterial peptides through a chemical reaction. The problems that bacteria invade organisms, and bacteria andmedicines are remained in tissues are solved. The invention also discloses a preparation method and application of the chemotactic antibacterial nanometer material.

Description

technical field [0001] The invention relates to medical hygiene materials, in particular to a chemotactic and antibacterial nanometer material and its preparation method and application. Background technique [0002] Infection poses a huge threat to human health, and antibiotics have brought hope to infectious diseases and saved many lives in the past few decades. However, problems such as allergic reactions, toxic reactions and bacterial resistance caused by antibiotics cannot be underestimated. Non-antibiotic antibacterial agents are an important direction of antibacterial research. [0003] Non-antibiotic antimicrobial agents currently being studied mainly include primitive metal nanoparticles, oxygen free radicals, photothermal materials, antimicrobial peptides, and so on. Although these materials and methods have certain advantages in killing bacteria, they also have some limitations, such as poor selectivity, damage to normal tissues and cells, low activity and insta...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61K47/34A61K41/00A61K47/04A61P31/04
CPCA61K38/08A61K47/34A61K41/0052A61K47/02A61P31/04A61K2300/00
Inventor 詹日兴罗高兴肖玲郭熠城倪文强
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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