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Novel ultrasonic/magnetic resonance dual-mode contrast agent and preparation method and application thereof

A contrast agent and dual-mode technology, which is applied in the field of medical imaging, can solve the problems of little research on contrast agents and limit the development of multi-mode imaging technology, and achieve the effect of uniform shape, excellent stability and no pollution to the environment

Inactive Publication Date: 2016-02-03
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, currently in the research of contrast agents, the existing clinically used contrast agents can only be used for one imaging method for inspection, and the contrast agents that can be used for both ultrasound and magnetic resonance imaging There are few studies, which will undoubtedly limit the development of multimodal imaging technology

Method used

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  • Novel ultrasonic/magnetic resonance dual-mode contrast agent and preparation method and application thereof
  • Novel ultrasonic/magnetic resonance dual-mode contrast agent and preparation method and application thereof
  • Novel ultrasonic/magnetic resonance dual-mode contrast agent and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Prepare 0.3 mg / mL DMSO solution of 2-phenylquinoline 3,3'-bipyridine dicarboxylate iridium complex and 0.3 mg / mL holmium acetate solution in DMSO for use. Take 2mL of the DMSO solution of the prepared 2-phenylquinoline 3,3'-bipyridinedicarboxylate iridium complex and place it in a single-necked flask, and add 10mg of polyvinylpyrrolidone (PVPK30), mix well, and raise the temperature to 50°C, keep the temperature constant for 0.1h, then take 2mL of the above-mentioned holmium acetate solution into the flask, and react for 0.25h. After the reaction, dialyze with deionized water for 12 hours, centrifuge and wash 3 times, disperse the obtained sample in deionized water, and perform ultrasonic and nuclear magnetic resonance tests.

[0042] figure 1 The scanning electron microscope spectrum of the dual-mode contrast agent prepared for this example, it can be seen from the figure that the contrast agent is spherical particles with good dispersibility and no agglomeration.

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Embodiment 2

[0047] Prepare 0.5 mg / mL DMSO solution of 2-phenylquinoline 3,3'-bipyridyl dicarboxylate iridium complex and 0.7 mg / mL holmium acetate solution in DMSO for use. Take 2mL of the DMSO solution of the prepared 2-phenylquinoline 3,3'-bipyridinedicarboxylate iridium complex and place it in a single-necked flask, and add 20mg of polyvinylpyrrolidone (PVPK30), mix well, and raise the temperature to 70°C, keep the temperature constant for 0.2h, then take 2mL of the above-mentioned holmium acetate solution into the flask, and react for 0.5h. After the reaction, dialyze with deionized water for 12 hours, centrifuge and wash 3 times, disperse the obtained sample in deionized water, and perform ultrasonic and nuclear magnetic resonance tests.

Embodiment 3

[0049] Prepare 0.5 mg / mL DMSO solution of 2-phenylquinoline 3,3'-bipyridyl iridium complex and 0.9 mg / mL holmium acetate solution in DMSO for use. Take 5mL of the DMSO solution of the prepared 2-phenylquinoline 3,3'-bipyridinedicarboxylate iridium complex and place it in a single-necked flask, and add 30mg of polyvinylpyrrolidone (PVPK30), mix well, and raise the temperature to 70°C, keep the temperature constant for 0.3h, then take 2mL of the above-mentioned holmium acetate solution into the flask, and react for 1h. After the reaction, dialyze with deionized water for 12 hours, centrifuge and wash 3 times, disperse the obtained sample in deionized water, and perform ultrasonic and nuclear magnetic resonance tests.

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Abstract

The invention relates to a novel ultrasonic / magnetic resonance dual-mode contrast agent and a preparation method and an application thereof; the contrast agent is a coordination polymer nanoparticle contrast agent with the surface modified by polyvinylpyrrolidone; the interior of the coordination polymer nanoparticle contrast agent has a cavity structure, the coordination polymer nanoparticle contrast agent is also doped with rare earth elements Ir and Ho. The preparation method comprises the steps: during preparation, preparing a DMSO solution of a 2-phenylquinoline 3,3'-iridium dipyridine dicarboxylate complex, adding polyvinylpyrrolidone, stirring and mixing evenly, heating up to 30-200 DEG C, keeping constant temperature for 0.1-2 h, then adding a DMSO solution of holmium acetate, carrying out a reaction for 0.1-48 h, after the reaction is finished, dialyzing for 10-12 h with deionized water, and centrifuging. The prepared dual-mode contrast agent is used in ultrasound contrast imaging and magnetic resonance contrast imaging. Compared with the prior art, the dual-mode contrast agent has the advantages of uniform morphology, good dispersion, excellent stability, simple synthetic process, easily obtained raw materials, no pollution to the environment, and quite good application prospects.

Description

technical field [0001] The invention belongs to the technical field of medical imaging, and relates to a novel ultrasound / magnetic resonance dual-mode contrast agent and its preparation method and application. Background technique [0002] Molecular imaging is a subject that combines medical imaging technology and molecular biology. In this subject, early disease information of the body can be obtained by using imaging instruments. Among the many imaging studies, ultrasound imaging has low medical cost, can obtain imaging images of any section of body tissue, has the characteristics of fast imaging, visible organ movement, timely diagnosis, etc., is painless, non-dangerous, and non-invasive; Resonance imaging, because it can perform multi-parameter imaging, provides rich diagnostic information, is fast and safe, and has a clear contrast between lesions and normal parts, has been widely used. [0003] Ultrasound imaging uses the physical characteristics of ultrasound and the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K49/12A61K49/18
Inventor 杨仕平张红卫杨红崔丽丽张晓芬阎聪洋潘立星
Owner SHANGHAI NORMAL UNIVERSITY
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