Blood flow estimates through replenishment curve fitting in ultrasound contrast imaging
An imaging and contrast agent technology, applied in the field of blood flow estimation technology, can solve problems such as the estimation of absolute quantification of flow parameters that are not applicable
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[0083] The present invention proposes a method for the quantification of organ perfusion based on the study of the reperfusion kinetics of microbubble-based ultrasound contrast agents (UCAs). This method requires administering UCA, waiting for a period of time to establish a steady state of UCA concentration in the organ or region of interest (usually between 5 and 30 seconds), applying one or more agents at a sufficiently high sound pressure to disrupt the frame, to disrupt UCA microbubbles in slices containing the image plane and monitor reperfusion or resupply kinetic properties. Achieving the desired steady state perfusion can be achieved by continuous infusion of UCA or by bolus in such a way that a fairly constant infusion rate is achieved over a period of several seconds (usually between 1 and 15 seconds).
[0084] Reperfusion dynamics
[0085] The reperfusion kinetics were analyzed on the basis of a signal that is linearly proportional to the local UCA concen...
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