Blood flow estimates through replenishment curve fitting in ultrasound contrast imaging

An imaging and contrast agent technology, applied in the field of blood flow estimation technology, can solve problems such as the estimation of absolute quantification of flow parameters that are not applicable

Active Publication Date: 2006-07-19
BRACCO SUISSE SA
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  • Abstract
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  • Claims
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Problems solved by technology

Extracted parameters are also specific to each instrument type, making comparisons between researchers using different equipment or setups impossible
Furthermore, the perfusion parameters extracted from the prior art are only relative estimates and are not suitable for the estimation of absolute quantification of flow parameters

Method used

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  • Blood flow estimates through replenishment curve fitting in ultrasound contrast imaging
  • Blood flow estimates through replenishment curve fitting in ultrasound contrast imaging
  • Blood flow estimates through replenishment curve fitting in ultrasound contrast imaging

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Embodiment Construction

[0083] The present invention proposes a method for the quantification of organ perfusion based on the study of the reperfusion kinetics of microbubble-based ultrasound contrast agents (UCAs). This method requires administering UCA, waiting for a period of time to establish a steady state of UCA concentration in the organ or region of interest (usually between 5 and 30 seconds), applying one or more agents at a sufficiently high sound pressure to disrupt the frame, to disrupt UCA microbubbles in slices containing the image plane and monitor reperfusion or resupply kinetic properties. Achieving the desired steady state perfusion can be achieved by continuous infusion of UCA or by bolus in such a way that a fairly constant infusion rate is achieved over a period of several seconds (usually between 1 and 15 seconds).

[0084] Reperfusion dynamics

[0085] The reperfusion kinetics were analyzed on the basis of a signal that is linearly proportional to the local UCA concen...

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Abstract

Systems and methods for non-invasively quantifying tissue perfusion achievable through a destruction-replenishment process by deriving at least one local tissue perfusion value that provides a signal representative of a local agent concentration during reperfusion. The system includes means for calibrating or relating a time function having a sigmoidal characteristic to a signal proportional to the local agent concentration during reperfusion, and at least one parameter of the function having a sigmoidal characteristic A value is associated with at least one local tissue perfusion value (eg, mean velocity, mean transit time, mean flow, perfused volume) or property (eg, blood flow pattern, flow distribution variance, or slope).

Description

technical field [0001] The present invention relates to a technique for blood flow estimation during destruction / replenishment monitoring of gas-filled microbubbles, wherein the flow parameters are derived from the analysis of the kinetic characteristics of the recharge. More specifically, the present invention relates to a method of non-invasively quantifying perfusion in living tissue. The invention also relates to a computer program for carrying out the method, and to a product containing the program. Furthermore, the invention relates to a corresponding system for the non-invasive quantification of perfusion, and a device for use in this system. Background technique [0002] The use of suspensions of air bubbles in a carrier liquid as effective ultrasound reflectors is well known in the art. The development of these suspensions as a means of enhancing ultrasound imaging follows early observations that rapid injection of aqueous solutions into veins causes dissolved gas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B8/06A61K49/22
Inventor 彼得・弗林京玛索・阿迪特伊莱瑞尔・乔瑞
Owner BRACCO SUISSE SA
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