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Application of Li2WO4 in preparing medicine

A technology of lithium tungstate and drugs, which is applied in the application field of lithium tungstate in pharmaceuticals, can solve the problems of no reports or patent applications for treatment-related diseases, and achieve improvement of neurodegenerative diseases, inhibition of hyperphosphorylation, and reduction of The effect of Aβ production

Inactive Publication Date: 2009-07-22
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Through literature search, it is found that lithium tungstate is currently limited to the application in the chemical industry, and there is no report or patent application for the treatment of related diseases.

Method used

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  • Application of Li2WO4 in preparing medicine
  • Application of Li2WO4 in preparing medicine
  • Application of Li2WO4 in preparing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: The role of lithium tungstate in promoting the growth of neonatal mouse cerebral cortex neurons

[0021] As shown in Table 1-2, compared with the vehicle control group, the low concentration lithium tungstate group had no significant difference in the total number of processes, the length of processes, and the number of neurons with processes; the middle concentration lithium tungstate group and the high concentration tungstate Compared with the vehicle control group, the total number of processes, the length of processes, and the number of neurons with processes in the lithium group were significantly increased, and the effect of the high-concentration lithium tungstate group was significant. And the effect is better than lithium chloride group, sodium tungstate group and lithium chloride+sodium tungstate group.

[0022] Table 1 Effect of Lithium Tungstate on Cultured Cerebral Cortex Neurons for 48h (x±s, n=10)

[0023]

[0024] Compared with the vehicle...

Embodiment 2

[0028] Example 2: Lithium tungstate reduces Aβ secreted by M146L cells 42 content

[0029] The M146L cell line is a CHO cell transfected with APP and mutant PS-1 genes of human AD patients. Quantitative detection of Aβ by ELISA 42 output. As shown in Table 3: low doses of lithium tungstate have no effect on the production of Aβ42, medium and high doses of lithium tungstate can significantly reduce the production of Aβ42, especially the inhibition rate of the high dose group exceeds 70%, showing a good dose effect relation. And the effect is better than lithium chloride group, sodium tungstate group and lithium chloride+sodium tungstate group.

[0030] Table 3 The effect of lithium tungstate on the Aβ42 secreted by M146L cells (x±s, n=8)

[0031]

[0032] Compared with the vehicle control group: * P** P<0.01

Embodiment 3

[0033] Example 3: Lithium tungstate reduces Aβ in model mice injected with streptozotocin 1-40 , Aβ 1-42 content

[0034] Streptozotocin (STZ) is a nitrosourea derivative that can selectively destroy islet cells in the periphery, cause glucose metabolism disorders, and lead to diabetes; in the center, it can block insulin receptor autophosphorylation and intrinsic Tyrosine kinase activity, resulting in impaired insulin signaling.

[0035] Select 20 adult SD rats and divide them into 5 groups: normal control group, solvent control group, low-, medium- and high-dose lithium tungstate groups. The solvent control group and the lithium tungstate low, medium and high dose groups were injected with STZ 10 μl (3 mg / kg) into the bilateral lateral ventricles with a stereotaxic apparatus, and the injection was repeated on the third day. The normal control group was replaced by STZ with an equal amount of normal saline as described above. One week after modeling, the low-, medium-, an...

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Abstract

The invention discloses the application of lithium tungstate in pharmaceuticals, especially in the preparation of drugs for treating neurodegenerative diseases, neuropathy caused by diabetes, and cerebral ischemia including brain dysfunction. Since lithium tungstate anion and cation are both active, the two play a synergistic effect and can better inhibit the activity of GSK-3. By inhibiting the activity of GSK-3α, reducing the production of Aβ to reduce SP; by inhibiting the activity of GSK-3β, inhibiting the hyperphosphorylation of tau protein to reduce NFT. By increasing the content of BDNF in cortical neurons, it can promote the survival and repair of nerve cells in the state of ischemia and hypoxia, and improve learning and memory dysfunction.

Description

technical field [0001] The invention relates to the application of lithium tungstate as an active ingredient in medicines for treating neurodegenerative diseases, treating neuropathy caused by diabetes, and treating cerebral ischemia (including brain dysfunction) and related diseases. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD), also known as senile dementia, is a clinical feature of progressive memory loss, cognitive impairment and personality changes, with extracellular senile plaques (senile plaques) appearing in the cerebral cortex and hippocampus. Plaque, SP), intracellular neurofibrillary tangles (neurofibrillary tangles, NFT) and loss of cholinergic neurons are pathologically characterized neurodegenerative diseases. [0003] SP is slightly spherical, and its main component is β-amyloid protein (amyloid β-protein, Aβ). The newly produced Aβ is soluble, not only has no neurotoxicity, but also has a certain neurotrophic effect. However,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61P25/28
Inventor 罗焕敏翁文
Owner JINAN UNIVERSITY
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