Medicinal composition of milkvetch root, chinaroot greenbrier and Hong Jingtian and its making method

A composition, technology of Rhodiola rosea, used in the field of medicine

Inactive Publication Date: 2009-08-12
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the preparation of drugs for improving brain function by using the interaction of astragalus or its extracts, rhodiola or its extracts, sarsaparilla or its extracts, and compatible prescriptions

Method used

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  • Medicinal composition of milkvetch root, chinaroot greenbrier and Hong Jingtian and its making method
  • Medicinal composition of milkvetch root, chinaroot greenbrier and Hong Jingtian and its making method
  • Medicinal composition of milkvetch root, chinaroot greenbrier and Hong Jingtian and its making method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0166] Example 1 Preparation, Identification and Content Determination of Astragalus Total Saponins

[0167] Preparation of Total Astragalus Saponins

[0168]Take 50kg of Radix Astragali medicinal material, add water and decoct three times, 1.5 hours each time, add 10 times the amount of water for the first time, and 8 times the amount for the second and third times, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.20-1.25 (60 ℃), with ethanol precipitation treatment for 2 times, the alcohol content in the solution for the first time is 75%, and the second time is 85%, each time it is refrigerated and placed, and the ethanol is recovered and concentrated to the equivalent of 10g of the original medicinal material per 1ml, and added to On the treated macroporous adsorption resin column, wash the column with 2 times the volume of water, then elute with 4 times the volume of 70% ethanol, collect the eluate, concentrate under reduced pressur...

Embodiment 2

[0187] Example 2 Preparation, Identification and Content Determination of Astragalus Polysaccharide

[0188] Preparation of astragalus polysaccharide

[0189] Take the Radix Astragali medicinal material, add 7 times the amount of 70% ethanol to extract twice, each time for 2 hours, discard the extract, take the dregs and add water to extract twice, combine the extract, concentrate until the ratio of the volume of the extract to the raw medicinal material is 1.05: 1. Add ethanol to precipitate to make the alcohol content reach 70%, filter to obtain a precipitate, wash the precipitate with 70% ethanol, dissolve it with an appropriate amount of water, filter, pass the filtrate through a macroporous resin, elute with water, collect the washing liquid, and put Concentrate the washing liquid until the ratio of the volume of the medicinal liquid to the medicinal material is 1:2.5, add ethanol to make the alcohol content reach 70%, and obtain a precipitate, wash and dehydrate the pr...

Embodiment 3

[0202] Example 3 Preparation, Identification and Content Determination of Rhodiola Rosea Extract

[0203] Preparation of Rhodiola Rosea Extract

[0204] Take 20kg of Rhodiola rosea medicinal material, grind it into coarse powder, add 70% ethanol to reflux and extract three times, each time for 1.5 hours, combine the extracts, filter, recover the ethanol from the filtrate to contain 1g of raw medicinal material per 2ml, and degrease with 2 times the amount of petroleum ether , discard the petroleum ether solution, extract with n-butanol saturated with water, concentrate under reduced pressure to a thick paste, add to the pre-treated macroporous resin, elute with water and different concentrations of ethanol in turn, and recover ethanol under reduced pressure to relative The density is 1.03~1.06 (60°C), and it can be obtained by spray drying.

[0205] Three batches of Rhodiola rosea extracts were prepared respectively, and the yields are shown in Table 2-3.

[0206] Identifi...

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Abstract

The invention belongs to the technical field of medicine, and discloses a new pharmaceutical composition for improving brain function and a preparation method thereof. It can be prepared from 2-200 parts of astragalus total saponins or astragalus polysaccharides, 6-160 parts of rhodiola rosea extract and 2-90 parts of smilax total saponins. It can be made into any clinically or pharmaceutically acceptable dosage form, preferably oral preparation and injection. The pharmaceutical composition of the present invention has clear active ingredients and exact content, which can jointly play the role of protecting cerebral ischemia or hypoxic damage, improving the learning and memory ability of senile dementia, vascular dementia, etc., and has remarkable effect, and is mainly used for preparing the medicine for improving brain function. drug. The preparation process is simple and easy, the quality of the preparation is high and stable, and it is suitable for large-scale industrial production.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition mainly made of astragalus or its extract, rhodiola rosea or its extract, and sarsaparilla or its extract, a preparation method thereof and a preparation method for improving brain function. functional medicine applications. 2. Background technology [0002] Brain dysfunction includes brain tissue ischemia or hypoxic injury, memory impairment, dementia, etc. Brain tissue is very sensitive to ischemia and hypoxia. With the aging trend of society and the prolongation of life expectancy, the incidence of ischemic cerebrovascular disease has increased significantly, seriously endangering human health and bringing heavy burdens to society and families. Cognitive dysfunction caused by cerebral ischemia and reperfusion has also received increasing attention. Memory impairment includes memory loss and hypomnesis etc. Dementia is a common senile disease, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61K36/481A61K36/41A61K31/715A61P9/10A61P25/00
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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