Compressed formed preparation

Abstract

The object of the invention is to provide a small troche which contains high content L-cysteine and ascorbic acid as medicinal composition as well as has excellent prepare-ability. The object is to provides a compression molding preparation which is characterized in containing 20 to 40 wt. % L-cysteine or the salt of L-Cysteine whose L-Cysteine calculated content is 20 to 40 wt. %, 30 to 70 wt. %ascorbic acid or the salt of ascorbic acid whose ascorbic acid calculated content is 30 to 70 wt. %, multi-crystalline cellulose whose content is totaled 7.5 to 25 wt. %, and 1 to 20 wt. % high-swelling property macromolecule.

Description

technical field [0001] The present invention relates to a compression molding preparation, more specifically, relates to a compression molding preparation containing high content of L-cysteine ​​and ascorbic acid as medicinal components. Background technique [0002] Preparations made by blending L-cysteine ​​and ascorbic acid, used to be used for pigmentation diseases such as age spots, freckles, sunburn, macules, general fatigue, hangover, acne, eczema, urticaria, macules, Prevention of drug rash, gum bleeding, epistaxis, physical fatigue, pregnancy, lactation, physical decline during and after illness, vitamin C supplementation in old age, etc. [0003] Moreover, for example, for pigmentation diseases such as age spots, freckles, and sunburn, general fatigue, hangover, acne, eczema, urticaria, macules, and drug rashes, the daily dosage of L-cysteine ​​is 240 mg 300 mg of ascorbic acid and 24 mg of calcium pantothenate. Vitamin C supplementation for age spots, freckles, ...

AI Technical Summary

Problems solved by technology

[0008] Moreover, in Patent Document 7, although it is clearly stated that the content of L-cysteine ​​is 22% by weight, the content of ascorbic acid is as little as 28% by weight; the content of L-cysteine ​​in plain tablets is 20% by weight. % or more, and containing 30% by weight of ascorbic acid, excellent manufacturability of tablets, so far not provided

[0009] And, the lozenge that contains L-cysteine ​​and ascorbic acid, even if can carry out a small amount of tableting, but when carrying out mass production, because the formulation additives such as the prepared excipient, its fluidity is poor and cannot be tabletted or Barriers to pelleting due to sticking or capping, large variations in component content, and large variations in weight make it impossible to efficiently manufacture

In addition, even if tablets can be made into tablets, in order to prevent the taste of cysteine, when film coating or sugar coating is applied to plain tablets, even if the content of the ingredients is not reduced, discoloration or cracking may occur during storage