A composite intrauterine device using copper salts as copper ion source

A technology of intrauterine device and composite material, which is applied in the field of composite material intrauterine device, can solve the problem of active oxygen damage to the uterus, and achieve the effect of avoiding damage and excellent contraceptive effect

Inactive Publication Date: 2007-08-01
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] The polymer-based composite intrauterine device using elemental copper particles (copper nanoparticles, copper microparticles) as the source of copper ions can well solve the above problems, but the process of oxidizing elemental copper to produce copper ions in the uterine cavity is always Accompanied by the generation of active oxygen, and active oxygen has a damaging effect on the uterus

Method used

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  • A composite intrauterine device using copper salts as copper ion source

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Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 25g CuCl 2 Ultrafine powder, 25g of medical grade low-density polyethylene (LDPE), using methods such as premixing, blending, pressure injection or injection molding, to prepare a γ-shaped composite material IUD.

[0026] Examples 2-27 were all prepared by a method similar to that of Example 1, and the composition of the prepared composite IUD is shown in Table 1.

[0027] Table 1 Composition of composite material IUD in each embodiment

[0028] Reality

[0029] example

[0030] The technical effect of using low-density polyethylene as the base material is obviously better than that of using silicone rubber as the base material, so the preferred base material is low-density polyethylene. CuCl 2 、CuSO 4 and Cu(NO 3 ) 2 etc., especially CuCl 2 for the best. Steroidal hormonal contraceptives can use the various progestogens available. Since the melting points of megestrol, norethindrone and levonorgestrel, etc. are higher than the therma...

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Abstract

The invention discloses a composite uterine pregnant contraceptive device based on copper salt as copper ion source, which is characterized by the following: adopting base material and active material to form kinds of shape through thermo plasticity or heat solidity; setting the weight quantity of active material at 0.5-50% corresponding to IUD; setting the base material as low-density polyethylene or silicon rubber; selecting active material from one kind of copper salt or copper salt and sulphanilamide haemostatic drug and steroid hormone contraceptive pill; reducing a series of hemorrhagic and pain on the clinic; avoiding the damage of active oxygen for uterus.

Description

technical field [0001] The invention relates to a female long-acting contraceptive and birth control device, specifically a composite intrauterine device with water-soluble copper salt as a copper ion source, which can be loaded with copper salt alone or in combination with copper salt, anti-inflammatory and hemostatic drugs or steroids. Hormonal contraceptives. technical background [0002] Intrauterine Device (IUD) is a safe, effective, economical, reversible and simple contraceptive tool, and it is also one of the most widely used methods in the world. There are two types of IUDs: inert and active. The inert IUD has been completely replaced by the active IUD due to its poor contraceptive effect. There are two main types of active IUDs: copper-loaded IUDs (Cu-IUDs) and extended-release hormonal contraceptive IUDs. Cu-IUD has the advantages of good contraceptive effect, long continuous use time, high cost performance, and reversibility, so it has become the most studied ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F6/14A61K33/34A61P15/18A61K31/565
Inventor 谢长生蔡水洲夏先平
Owner HUAZHONG UNIV OF SCI & TECH
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