Preparation method of allogenic blood vessel decellularised scaffold

A decellularized scaffold and allogeneic technology, which is applied in the field of preparation of allogeneic vascular decellularized scaffolds, can solve the problems of limited sources of autologous blood vessels, low long-term patency rate, and inability to guarantee clinical use, etc., to achieve cell adhesion, Good tissue compatibility and biodegradability, favorable exchange effect
CN101011604AInactive Publication Date: 2007-08-08THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
Publication Date
2007-08-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for preparing the conspecific allo vessel de-cell support, which comprises that using the abdominal aorta of rabbit of New Zealand, using surface activator Triton X-100 to extract the liposome of cell membrane, and digesting the parenzyme, using nuclease DNAse and RNAse to degrade the DNA and RNA of cell, to obtain the support. The invention uses the similar structures of conspecific allo materials, with better histocompatibility, to support healing after surgery, with simple preparation and high efficiency. And the invention can be transplanted with low caused immunity reaction of host, to supply physical strength and tension. The invention can be used to replace blood vessel.
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Description

technical field

[0001] The invention relates to a preparation method of a blood vessel decellularized scaffold, in particular to a preparation method of an allogeneic blood vessel decellularized scaffold. Background technique

[0002] Arterial ischemic diseases, mainly represented by arteriosclerotic vascular diseases, are an important cause of death.

[0003] Before the present invention, arterial bypass surgery was one of the main methods for treating arteriosclerotic vascular diseases, that is, using autologous blood vessels or artificial blood vessels as graft materials to perform bypass surgery. At present, the sources of available autologous blood vessels are limited, and most operations cannot be performed at all; artificial blood vessels, especially those with a diameter of less than 4-6 mm, have low short-term and long-term patency rates and cannot be used clinically. Contents of the invention

[0004] The purpose of the present invention is to overcome the above...

Claims

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