Agent for treatment of keratoconjunctive disorder
A therapeutic agent and corneal technology, applied in sensory diseases, organic active ingredients, organic chemistry, etc., can solve problems such as reports of pharmacological effects that have not yet been studied, and achieve the effect of improving the effect
Inactive Publication Date: 2007-08-08
SANTEN PHARMA CO LTD
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Problems solved by technology
[0004] However, there is no report on the pharmacological effects of the above-mentioned carboxylic acid compounds on eye diseases such as keratoconjunctivopathy
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[0021] The results of pharmacological tests and preparation examples are given below. The above examples are used to further understand the present invention, and the scope of the present invention is not limited thereto.
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Abstract
A new medicinal use of E-4-[4-(5-methyl-2phenyl-4-oxazolylmethoxy)benzyloxyimino]-4-phenylbutyric acid, Z-2-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-2-(4-phenoxyphenyl)acetic acid, 2-[2-propyl-3[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acid, 2(S)-methoxy-3-[4-[3-(4phenoxyphenoxy)propoxy]phenyl]propionic acid, or a salt of any of these. These carboxylic acid compounds and salts thereof each produces an excellent alleviating effect on corneal disorder models and is useful as a therapeutic agent for keratoconjunctiva disorders such as dry eye, corneal ulcer, keratitis, conjunctivitis, superficial punctate keratopathy, subepithelial corneal defects, subepithelial conjunctival defects, keratoconjunctivitis sicca, superior limbic keratoconjunctivitis, and filamentary keratitis.
Description
technical field [0001] The present invention relates to dry eye, corneal ulcer, keratitis, conjunctivitis, superficial punctate keratopathy, corneal epithelial defect, conjunctival epithelial defect, keratoconjunctivitis sicca, and superior keratoconjunctivitis (superior limbickeratoconjunctivitis), filamentous keratitis (Filamentary Keratitis) and other keratoconjunctivitis therapeutic agents, the therapeutic agent contains (1) E-4-[4-(5-methyl-2-phenyl-4-oxo Azolylmethoxy)benzyloxyimino]-4-phenylbutanoic acid, (2)Z-2-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy) Benzyloxyimino]-2-(4-phenoxyphenyl)acetic acid, (3)2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl) )-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acid, (4)2(S)-methoxy-3-[4-[3-(4-phenoxyphenoxy) Propoxy] phenyl] propionic acid and at least one of the salts of the above compounds as an active ingredient. Background technique [0002] The cornea is a transparent, avascular tissue with a diameter of about 1 cm and a thickness ...
Claims
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K31/421A61K31/603A61P27/02A61P43/00C07D263/32
CPCA61K31/603A61K31/421A61K31/192A61K9/0048A61P27/02A61P43/00
Inventor 中村雅胤平井慎一郎柴垣圭一
Owner SANTEN PHARMA CO LTD
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