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Anti-malaria prime/boost vaccines

A malaria and antigen technology, applied in the medical field, can solve the problems of insufficient protection and insufficient immunogenicity

Inactive Publication Date: 2007-11-07
JANSSEN VACCINES & PREVENTION BV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Other vaccine candidates tested were either insufficiently immunogenic or immunogenic but insufficiently protective

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0100] Heterologous Prime / Boost Immunization of Rhesus Monkeys Using Recombinant Adenoviral Vectors and Purified Adjuvanted Proteins

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Abstract

The invention relates to novel vaccine regimens in which specific prime / boost regimens are applied using low-neutralized recombinant adenoviral vectors harboring nucleic acids encoding antigens from Plasmodium falciparum and purified recombinant protein vaccines such as RTS,S, in the context of appropriate adjuvants.

Description

technical field [0001] The present invention relates to the field of medicine. Specifically, the present invention relates to a novel prime / boost vaccine strategy for preventing falciparum malaria using recombinantly produced adenovirus vectors and purified proteins combined with adjuvants. Background technique [0002] Malaria is currently one of the most prevalent infectious diseases in tropical and subtropical regions of the world. Each year, malaria infection kills an estimated 2.7 million people in developing countries. The widespread prevalence and increased incidence of malaria is due to the increase in the number of drug-resistant parasites and insecticide-resistant parasite vectors. Other factors include environmental and climate change, national instability, and increased population mobility. [0003] Malaria is caused by mosquito-borne blood-borne protozoan parasites belonging to the genus Plasmodium. Four species of Plasmodium (Plasmodium falciparum, P.vivax,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/015
CPCA61K2039/55572A61K2039/5256A61K2039/55577A61K39/015A61K2039/6075A61P33/06A61P37/02A61P43/00Y02A50/30
Inventor 马里亚·格拉西亚·帕乌杰普·古德斯米特约瑟夫·D·科恩帕特里斯·M·杜波依斯V·安·斯图尔特唐纳德·海普纳尔
Owner JANSSEN VACCINES & PREVENTION BV
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