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Medicinal composition with anti-infective and anti-inflammatory functions

An anti-inflammatory effect and composition technology, applied in the field of pharmaceutical compositions containing total flavonoids of Shegan and andrographolide or its derivatives, can solve problems such as deficiency

Active Publication Date: 2010-12-08
GUANGDONG QIFANG MEDICINES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, humans are often in a passive position in the competition between humans and bacteria. Drug-resistant bacterial infections are an urgent problem to be solved in the current medical field, but there is currently no effective means to fundamentally solve the problem in the body.

Method used

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  • Medicinal composition with anti-infective and anti-inflammatory functions
  • Medicinal composition with anti-infective and anti-inflammatory functions
  • Medicinal composition with anti-infective and anti-inflammatory functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Capsules Each capsule contains:

[0021]

[0022]Capsule preparation process: mix andrographolide and / or its derivative powder and dry total flavonoid powder according to the above-mentioned ratio according to the above-mentioned method, sieve, dry at 60°C, and then add Hydroxypropyl cellulose and 0.5% magnesium stearate are granulated with 50% ethanol according to a conventional method and then filled with hollow capsules to make capsules.

Embodiment 2

[0023] Example 2 Tablets Each tablet contains:

[0024]

[0025] According to the ratio in the above prescription, andrographolide and total flavonoids powder of Shegan are mixed evenly according to the method mentioned above, and after drying at 60°C, hydroxypropyl cellulose and 0.5% magnesium stearate are added, and then 50 % ethanol was granulated by conventional methods and then compressed into tablets.

Embodiment 3

[0026] Embodiment 3 injection Each (bottle) contains:

[0027]

[0028]

[0029] Injection preparation process 1:

[0030] According to the ratio in the above prescription, after weighing the medicine, mix it evenly, prepare the liquid according to the conventional method, adjust the pH value, filter with activated carbon, collect the filtrate, fill it, and sterilize it to make small-volume injection and large-volume injection , large-volume injection with appropriate amount of sodium chloride for isotonic adjustment. Or directly subpackage in aseptic containers after ultrafiltration to make small-capacity injections and large-capacity injections.

[0031] Injection preparation process 2:

[0032] According to the ratio in the above prescription, after weighing the medicine, mix it evenly, do the liquid preparation according to the conventional method, adjust the pH value, perform ultrafiltration, collect the ultrafiltrate, fill and seal, and freeze-dry to make a freez...

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Abstract

The invention is concerned with the compound medicine for dishimishing infenction and inflammation. It includes: Shegan total flavonoids and andrographolidume or derivatives thereof with the weight ratio of 1:20 to 20:1(endpoint included), which can execute all kinds of preparation with other supplementary materials or excipients that are pharmacy acceptable.

Description

[technical field] [0001] The invention relates to an anti-infection and anti-inflammation pharmaceutical composition, specifically a pharmaceutical composition containing total flavonoids and andrographolide or derivatives thereof. [Background technique] [0002] In recent years, the anti-inflammatory effect of natural medicines has been widely concerned by people. Clinical and experimental evidences show that many natural medicines have good anti-inflammatory effects. Experimental studies have confirmed that the anti-inflammatory mechanism of natural medicines is manifested in multiple ways, corresponding to modern pharmacology, generally mainly affecting the function of the thalamus-pituitary-adrenal cortex axis (HPAA), interfering with arachidonic acid metabolism, and inhibiting inflammatory mediators , Anti-thrombosis, etc. With the continuous deepening of research on inflammation, the anti-inflammatory effect of natural medicines is also closely related to the generatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/88A61K31/7048A61P31/00A61P29/00A61K31/365A61K31/352
Inventor 杨春玮孔庆文
Owner GUANGDONG QIFANG MEDICINES CO LTD