Method for preparing honeysuckle extraction

A honeysuckle extract and filtration technology are applied in the field of preparation of honeysuckle extract, which can solve the problems of low purity of active ingredients and formulation stability, and achieve the effects of reducing allergenic components, reducing the dissolution of impurities, and increasing the content.

Inactive Publication Date: 2007-12-12
SHANGHAI KAIBAO PHARMA
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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a method for extracting active extracts from Flos Lonicerae Flos Lonicerae, which is used to solve preparations with higher requirements, such as injections, to solve the problem of low purity of active components (such as organic acid components) and Preparation stability and safety issues

Method used

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  • Method for preparing honeysuckle extraction

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preparation example Construction

[0016] Referring to Fig. 1, a kind of preparation method of honeysuckle extract, this method comprises the following steps:

[0017] 1. Decoction and extraction: take the honeysuckle medicinal material, add water to decoct for 1-2 hours, filter the medicinal liquid, add water to the medicinal residue and decoct for 0.5-1 hour, filter the medicinal liquid, discard the medicinal residue; combine the two decoctions, Concentrate the decoction to a relative density of 1.05-1.20 (60°C), and cool to room temperature to obtain a decoction;

[0018] 2. Purification: add alkali solution to the decoction and stir to adjust the pH value to 11-12, stir, filter, and double the amount of precipitate, stir and suspend the alcohol solution, add acid solution and stir to adjust the pH value to 3-6, centrifuge Filtrate, recover the alcohol solution from the filtrate, concentrate to a relative density of 1.02-1.10 (60°C), after cooling, refrigerate at 0-10°C for more than 24 hours, and filter to ...

Embodiment

[0029] Weigh 4000g of honeysuckle, add 16 times the amount of purified water and decoct (95°C) for 1.5 hours, filter to obtain the medicinal liquid, add 12 times the amount of water and decoct (95°C) for 1 hour, filter , to obtain the medicinal solution, discard the medicinal residues, combine two decoctions, concentrate under reduced pressure to a relative density of 1.20 (60°C), add about 2000ml of 20% milk of lime to adjust the pH value to 12, stir to make the reaction complete, filter, and the precipitate weighs Weight, a total of 3200g, divided into four equal parts, respectively add 5 times the amount of 95% ethanol 4000ml each, stir, fully suspend, adjust the pH value to 3 (the first part) and 4 (the second part) with 40% sulfuric acid solution respectively , 5 (the third part), 6 (the fourth part), fully stirred, filtered, the filtrate recovered ethanol, each concentrated under reduced pressure to a relative density of 1.08 (60 ° C), let cool, refrigerated (5 ° C) for 4...

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Abstract

The invention provides a preparation method of honeysuckle extract, and belongs to the field of preparative technique of Chinese traditional medicine. The inventive method comprises decocting honeysuckle with water for extraction, removing most impurities through mercaptan method, and refining through extraction method with water saturated n-butanol. Compared with present technology, The inventive method guarantees the extraction of effective ingredient from honeysuckle, reduces contamination of impurity; can effectively remove impurities, reduce sensitization ingredient, and improve the content of total effective ingredient .The method can overcome the defects in present technology, has simple operation, and provides technological conditions in favor of industrial production.

Description

technical field [0001] The present invention relates to the technical field of preparation of traditional Chinese medicines, in particular to a method for extracting and purifying active ingredients of traditional Chinese medicines, in particular to a method for preparing honeysuckle extracts, and in particular to a method for extracting and purifying honeysuckle extracts to obtain effective extracts mainly composed of chlorogenic acid. method of extraction. Background technique [0002] Lonicera japonica Thunb., Lonicera hypoglauca Miq., Lonicera confusa DC. or Lonicera dasystyla Rehd. are the dry flower buds or the first flowers of Lonicera dasystyla Rehd. Honeysuckle is a commonly used traditional Chinese medicine, cold in nature and sweet in taste. It has significant heat-clearing and detoxifying, anti-bacterial, anti-inflammatory and anti-viral effects. It cools and dispels wind-heat, and is used for carbuncle and furuncle, sore throat, erysipelas, toxic dysentery due ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355A61P11/04A61P17/02A61P31/04A61P31/12C07C67/58
Inventor 薛东升
Owner SHANGHAI KAIBAO PHARMA
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