Eye implanted gel containing cyclosporin

A technology of cyclosporine and gel, which is applied in the field of medicine to achieve good biocompatibility, high safety, and the effect of preventing scarring

Inactive Publication Date: 2007-12-12
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The research on the preparation of sustained-release preparations by embedding cyclosporine in cross-linked hyaluronic acid has not been published in the literature

Method used

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  • Eye implanted gel containing cyclosporin

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Dissolve 0.125 g of sodium hyaluronate (average molecular weight 1.415 million Daltons) in 5 ml of Tris-HCl (pH 4.5) buffer solution, add 12.5 mg of adipate dihydrazide (ADH), add cyclosporine A 0.25 g of fine powder, grinded evenly; another 30 mg of ethyl (N, N-dimethylaminopropyl) carbodiimide (EDCI) was dissolved in 1 ml of Tris-HCl (pH4.5) buffer solution, and then Pour into the above mixed solution of sodium hyaluronate, ADH and cyclosporine A, grind it evenly, pour it on a clean glass plate, flatten it, or pour it into the gap between two clean glass plates fixed in advance, put Place the glass plate horizontally and react for 2 to 24 hours until the reaction solution is completely gelled. Gel sheets of different thicknesses can be obtained by adjusting the size of the glass plate or the distance between the two glass plates. The thickness of the gel sheet used for glaucoma trabecular surgery is 0.45-0.5 mm, which is suitable for intraocular implantation. The thi...

Embodiment 2

[0021] Dissolve 0.125 g of sodium hyaluronate (average molecular weight: 370,000 Daltons) in 4 ml of Tris-HCl (pH4.0) buffer solution, add 21.7 mg of adipate dihydrazide (ADH), add cyclosporin A Fine powder 0.25 g, grind well; mix well; take another ethyl (N, N-dimethylaminopropyl) carbodiimide (EDCI) 30 mg dissolved in 1 ml Tris-HCl (pH4.0) buffer solution, and then poured into the above mixed solution of sodium hyaluronate, ADH and cyclosporin A, grind well, and then operate according to the steps described in Example 1 until the finished product is obtained.

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Abstract

The invention relates to ocular implantation gel containing ciclosporin and its preparation method and application. The gel is characterized in that ciclosporin disperses in cross linked hyaluronic acid gel, and the weight ratio of cross linked hyaluronic acid and ciclosporin is 1:5-5:1.The preparation method of the gel comprises suspending ciclosporin in sodium hyaluronateaqueous solution, mixing with cross-linking agent for reaction to form gel, purifying, cutting, packaging, and sterilizing to obtain final product. The gel can be be used for preparation of ocular drug implants for preventing adhesion of humor aquosus through filtering channel in non penetrable joist operation of glaucoma, improving filterability and keeping filtering channel, controlling intraocular pressure after operation, preventing rejection reaction after corneal transplantation and some ocular autoimmune disease.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an eye implant gel containing cyclosporine, a preparation method and application thereof. Background technique [0002] Cyclosporine (Cyclosporine) is a specific anti-drug inhibitor, and cyclosporine A (Cyclosporine A, CyA), which is commonly used in clinical practice, is currently recognized as the most effective drug against organ transplant rejection. It selectively inhibits helper lymphocytes, interferes with the activity of lymphocytes, and blocks the humoral and cellular effector mechanisms involved in rejection, thereby inhibiting rejection and immune responses. Oral preparations and injections of CyA are widely used in the treatment of rejection after organ transplantation, and CyA eye drops are mainly used in the treatment of corneal transplantation rejection, autoimmune eye disease and dry eye in ophthalmology, such as CN99102848 and CN02117619 Respectively disclose the prescript...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/13A61K9/00A61K47/36A61P37/06
Inventor 凌沛学贺艳丽陈建英刘杰汪敏荣晓花
Owner 凌沛学
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