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Miniaturized flow controller using closed loop regulation
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A technology of a controller and a fluid sensor, applied in the general field of the present invention, can solve problems such as unsuitable use of a flow cytometer, and achieve the effects of enhancing the ability of biological defense, saving lives, and improving the level of medical care.
Active Publication Date: 2012-08-08
HONEYWELL INT INC
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[0007] Therefore, in remote locations or for continuous blood monitoring, this type of flow cytometer is usually not suitable
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[0049] figure 1 is a perspective view of an exemplary miniature portable blood cell counter according to the present invention. The hemocytometer is indicated by reference numeral 10 and includes a housing 12 and a removable or replaceable cartridge 14 . The exemplary housing 12 includes a base 16 , a cover 18 , and a hinge 20 connecting the base 16 to the cover 18 . Base 16 includes light sources 22a and 22b, associated optics and required electronics for operating the hemocytometer. Cover 12 includes a manual pressure application element, a pressure chamber with a control microvalve, and light detectors 24a and 24b with associated optics.
[0050] Removable cartridge 14 preferably receives sample fluid via sample collection port 32 . When removable cartridge 14 is not in use, cover 38 may be used to protect sample collection port 32 . The removable chuck 14 preferably performs hemodilution, erythrocyte lysis of cells, and hydrodynamic focusing for core formation. The re...
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Abstract
An apparatus having scattering and multi-color fluorescence detecting, analyzing and identification capabilities of blood or other fluids of interest. The sample to be tested may be entered in a disposable microfluidic cartridge (14) which in turn is insertable in a hand-holdable or implantable miniaturized and portable cytometer instrument (10). This cytometer has significant application in biological warfare agent detection, hematology and other clinical and research fields.
Description
[0001] This application is a continuation of US Patent Application 10 / 304,773, filed November 26, 2002, which in turn is part of US Patent Application 09 / 630,924, filed August 2, 2000, and US Patent 6,597,438 Continuing to apply, and this application claims the priority of the above earlier application. The above patent documents are hereby incorporated by reference. [0002] Cross Reference to Related Co-Pending Applications [0003] This application is related to: Co-pending U.S. Patent Application Serial No. 09 / 630,927, filed August 2, 2000, by Cabuz et al. Co-pending U.S. Patent Application Serial No. 09 / 630,924, filed August 2, 2000, entitled "Portable Flow Cytometer"; Co-pending U.S. Patent Application Serial No. 09 / 630,923, entitled "Optical Detection System for a Flow Cytometer," filed June 29, 2001, by Fritz; and U.S. Patent Application Serial No. 09 / 404,560, entitled "Addressable Valve Arrays for Proportional Pressure or Flow Control," filed September 23, 1999, by C...
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