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Synergistic combinations of non-steroidal antiinflammatory drugs with alpha-2 delta-ligands

A drug, ligand technology for the veterinary treatment of pain and/or inflammation in cats and horses, Carprofen with alpha-2-delta ligands, Dog field

Inactive Publication Date: 2008-05-14
PFIZER INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] No alpha-2-delta ligands have been approved for veterinary use

Method used

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  • Synergistic combinations of non-steroidal antiinflammatory drugs with alpha-2 delta-ligands
  • Synergistic combinations of non-steroidal antiinflammatory drugs with alpha-2 delta-ligands
  • Synergistic combinations of non-steroidal antiinflammatory drugs with alpha-2 delta-ligands

Examples

Experimental program
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Embodiment 1

[0183] The purpose of this experiment was to describe the anti-nociceptive and anti-inflammatory effects of gabapentin co-administered with carprofen in rats. In this example, gabapentin, carprofen, and the combination of gabapentin and carprofen were evaluated in a standard rat carrageenan footpad thermal hyperalgesia assay. The assay utilizes a seaweed extract (carrageenan), which, when injected into the footpads of test animals, causes sterile inflammation, thereby lowering the pain threshold. Anti-epileptic agents with analgesic properties, such as gabapentin, raise pain thresholds to normal values, thereby rendering animals tolerant to external pain for prolonged periods of time relative to untreated control animals.

[0184] As shown in Figure 1, gabapentin and carprofen were provided separately (gabapentin at 120 minutes post dose; carprofen at 120 minutes post dose). Each data point represents the mean and standard deviation of the mean. Data for each drug were fitte...

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Abstract

This invention relates to synergistic combinations of non-steroidal anti not inflammatory drugs, particularly carprofen, with alpha-2-delta ligands, such as gabapentin or pregabalin, for veterinary treatment of pain and / or inflammation, particularly in dogs, cats and horses.

Description

field of invention [0001] The present invention relates to combinations of non-steroidal anti-inflammatory drugs (NSAIDs) with alpha-2-delta ligands, in particular carprofen and alpha-2-delta ligands such as gabapentin or pregabalin. More specifically, the present invention relates to combinations of NSAIDs and alpha-2-delta ligands showing synergy and the use of such combinations in the veterinary treatment of pain and / or inflammation in mammals, especially dogs, cats and horses use. Background of the invention [0002] The use of NSAIDs in dogs, cats and horses is more restricted than the use of NSAIDs in humans. Thus, there is not much veterinary experience and knowledge surrounding the safety and efficacy issues of NSAID use in these animals. In veterinary medicine, for example, the most common indications for NSAIDs are degenerative joint disease (DJD) and osteoarthritis, which in dogs, cats and horses often results from the development of various diseases as well as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/195A61K31/405A61P29/00
CPCA61K31/405A61K31/195A61P29/00A61P29/02A61P39/00A61P43/00A61K2300/00
Inventor A·P·福斯特
Owner PFIZER INC
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