Method for refining valid target of bitter gourd for dropping blood sugar

A technology of effective parts and refining methods, applied in the field of medicine, can solve the problems of many impurities, affecting drug efficacy and product quality, and low content of active ingredients, and achieve the effects of simple process, convenient quality control, and improved preparation level

Inactive Publication Date: 2008-05-21
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above process has many impurities, low content of active ingredients, a lot of sugars, and certain moisture-absorbing ingredients, which affect the efficacy and product quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The raw material is balsam pear with impurities removed, dried and crushed, and refluxed with 90% ethanol to extract twice, each time the amount is 7 or 5 times the weight of the raw medicinal material, the extraction time is 2 or 1 hour, the extracts are combined, filtered, and the ethanol is recovered , concentrated to get the medicinal extract, the medicinal extract is diluted with water to 15 times the volume of the original medicinal material, and adsorbed on a resin column. The weight ratio of the original medicinal material and resin is 1: 3, washed with water, and eluted with 50% ethanol solution for 15 resin column volumes , collect the ethanol eluent, add activated carbon according to the volume of the eluent at 10%, heat to reflux for 2 hours, filter, concentrate under reduced pressure, and dry in vacuum to obtain Momordica charantrin. The content of momordica glycosides in the effective part of the bitter gourd for lowering blood sugar by the method can reach...

Embodiment 2

[0021] The raw material is balsam pear that removes impurities, dried and crushed, and refluxed with 70% ethanol to extract twice, each time the amount is 8 or 6 times the weight of the raw medicinal material, the extraction time is 2 or 2 hours, the extracts are combined, filtered, and the ethanol is recovered , concentrated to obtain medicinal extract, the medicinal extract is diluted with water to 25 times the volume of the original medicinal material, and adsorbed on a resin column. The weight ratio of the original medicinal material and resin is 1: 5, washed with water, and eluted with 70% ethanol solution for 20 resin column volumes , collect the ethanol eluent, add activated carbon according to the volume of the eluent at 7%, ultrasonicate for 1.5 hours, filter, concentrate under reduced pressure, and dry in vacuum to obtain Momordica charantrin. The content of momordica glycosides in the effective part of the bitter gourd for lowering blood sugar by the method can reach...

Embodiment 3

[0023] The raw material is balsam pear with impurities removed, dried and crushed, and refluxed with 70% ethanol to extract twice, each dosage is 10 or 8 times the weight of raw medicinal materials, and the extraction time is 2 or 1 hour. Combine the extracts, filter, and recover ethanol , concentrated to obtain medicinal extract, the medicinal extract is diluted with water to 25 times the volume of the original medicinal material, and adsorbed on a resin column. The weight ratio of the original medicinal material and resin is 1: 5, washed with water, and eluted with 70% ethanol solution for 20 column volumes, Collect the ethanol eluent, add diatomaceous earth according to the volume of the eluent at 7%, heat to reflux for 2 hours, filter, concentrate under reduced pressure, and dry in vacuo to obtain Momordica charantrin. The content of momordica glycosides in the effective part of the bitter gourd for lowering blood sugar by the method can reach more than 50%.

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PUM

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Abstract

The invention belongs to the technical field of medicine and discloses a refining method of an effective part of bitter gourd for reducing blood sugar, comprising the steps that: (1) the bitter gourd medicine liquid is prepared before decoloring and refining: the decoction sheet of the bitter gourd is dried, crushed, extracted in an recycling manner by ethanol and concentrated to gain the extract; the extract is diluted, absorbed through big-pore absorbing resin column, washed, eluted with the ethanol solution to obtain the bitter gourd medicine liquid before decoloring and refining; (2) a refining process is carried out: the ethanol eluting solution of the resin column is collected and a discoloring agent is added , the mixing solution is heated and recycled, filtered, concentrated after reducing the pressure, dried in vacuum to obtain the steroidal glucoside of the bitter gourd. The steroidal glucoside of the bitter gourd extracted by the method of the invention can be directly made into various preparations, such as troche, capsule, grain, oral liquid, tablet, suspension, pill, cataplasma and paste, etc. Compared with the traditional technique, the invention is characterized by small volume, strong resistance against moisture and high content of the effective component. Compared with a solvent extracting method, the invention does not use organic toxic solvent which volatilizes easily in the technological flow, thus, the invention has safe and reliable operation, low production cost and no pollution to the environment.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a method for refining bitter melon effective fractions (KGE) for lowering blood sugar, in particular to a method for refining steroidal components of effective fractions for lowering blood sugar in bitter melon. Background technique [0002] Bitter gourd is a traditional Chinese medicine, and there are many records in ancient prescriptions. In recent years, domestic and foreign studies and a large number of literature reports have shown that bitter melon has a sustained and efficient hypoglycemic effect without any toxic and side effects. The active ingredients contained in bitter melon can not only regulate blood sugar by promoting the secretion of insulin by β-cells, but also have insulin-like effects, and the oral curative effect is definite. Developing it into a highly efficient, low-toxic, and cheap modern Chinese medicine preparation for treating type II diabetes has broad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/42A61K9/00A61P3/10A61K131/00
Inventor 赵余庆关健
Owner SHENYANG PHARMA UNIVERSITY
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