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Compound preparation for preventing and controlling chronic renal failure heart reconstruction and preparation thereof

A compound preparation and kidney function technology, applied in the field of traditional Chinese medicine, can solve the problems of not being able to significantly reduce mortality and inconsistent pathogenesis, and achieve the effects of improving anemia, preventing cardiac hypertrophy, and preventing collagen hyperplasia

Inactive Publication Date: 2008-08-20
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The current research has inconsistent views on the above pathogenesis, and the current treatment measures still cannot significantly reduce the mortality rate. Therefore, finding drugs with good curative effect is still a research hotspot in this field

Method used

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  • Compound preparation for preventing and controlling chronic renal failure heart reconstruction and preparation thereof
  • Compound preparation for preventing and controlling chronic renal failure heart reconstruction and preparation thereof
  • Compound preparation for preventing and controlling chronic renal failure heart reconstruction and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Using raw materials: 5 grams of rhubarb, 5 grams of salvia miltiorrhiza, 5 grams of peach kernel, 5 grams of raw astragalus, 5 grams of Radix Ophiopogon, 3 grams of antler slices, and 3 grams of turmeric, adding 7 times the amount of 90% ethanol and heat reflux for 1 hour to obtain Add 7 times the amount of 50% ethanol to the extract and reflux for 1 hour to obtain the extract, combine and mix the two extracts, dry, add appropriate auxiliary materials according to the conventional method, and make a solid oral dosage form. After the extracts are combined, add dextrin, spray dry to make fine powder, and make granules by dry granulation; or add sodium hydroxymethyl starch, micropowder silica gel, soluble starch, lactose, magnesium stearate, mix well, and 95% ethanol granules

Embodiment 2

[0032] Raw materials used: 50 grams of rhubarb, 50 grams of salvia miltiorrhiza, 30 grams of peach kernel, 60 grams of raw astragalus, 60 grams of Radix Ophiopogon, 50 grams of antler slices, and 30 grams of turmeric. Add 7 times the amount of 90% ethanol and heat reflux for 1 hour to obtain Add 7 times the amount of 50% ethanol to the extract and reflux for 1 hour to obtain the extract, combine and mix the two extracts, dry, add appropriate auxiliary materials according to the conventional method, and make a solid oral dosage form. After the extracts are combined, add dextrin, spray dry to make fine powder, and make granules by dry granulation; or add sodium hydroxymethyl starch, micropowder silica gel, soluble starch, lactose, magnesium stearate, mix well, and 95% ethanol granules.

Embodiment 3

[0034] Using raw materials: 10 grams of rhubarb, 10 grams of salvia miltiorrhiza, 10 grams of peach kernel, 20 grams of raw astragalus, 20 grams of Radix Ophiopogon, 10 grams of antler slices, 10 grams of turmeric, adding 7 times the amount of 90% ethanol and heat reflux for 1 hour to obtain Add 7 times the amount of 50% ethanol to the extract and reflux for 1 hour to obtain the extract, combine and mix the two extracts, dry, add appropriate auxiliary materials according to the conventional method, and make a solid oral dosage form. After the extracts are combined, add dextrin, spray dry to make fine powder, and make granules by dry granulation; or add sodium hydroxymethyl starch, micropowder silica gel, soluble starch, lactose, magnesium stearate, mix well, and 95% ethanol granules.

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Abstract

The invention relates to a Chinese herbal medicine compound preparation for treating and preventing chronic renal failure and cardiac remodeling, belonging to the field of Chinese herbal medicine. On the basis of the theory of ''coordination between heart and kidney'' of the Chinese traditional medicine, the invention adopts the Chinese herbal medicine, comprising Chinese rhubarb, danshen root, peach nut, hoantchy root, dwarf lilyturf tuber, buckhom sheet and turmeric root-tuber, to make into a solid orally-taking preparation according to the principle of treatment that ''root causes'' benefit the heart and warm the kidney and that ''symptoms'' dissolve the stasis. Shown via experiments, the compound preparation has the functions of reducing the weight of hypertrophic cardiac muscle and restraining myocardial remodeling and registers as the reduction of the heart-weight index and the corresponding index of left ventricle, the reduction of positive presentation of heart muscle collagen and the reduction of the PCNA positive cell numbers. The Chinese herbal medicine compound preparation for treating and preventing chronic renal failure and cardiac remodeling can efficiently prevent myocardial hypertrophy and collagen hyperplasia, restrain myocardial fibrosis and reverse left ventricular remodeling and can be used for treating and preventing chronic renal failure and cardiac remodeling. The Chinese herbal medicine compound preparation has the advantages of low cost, safety and reliability, and good curative effect in clinical application.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a compound preparation for preventing and treating cardiac remodeling in chronic renal failure and a preparation method thereof. technical background: [0002] Chronic renal failure (CRF) can lead to dysfunction of various systems, and cardiovascular disease (CVD) is its main complication. According to foreign data, the incidence of cardiovascular complications of CRF is 10-30 times that of the general population. Although there is a guarantee of alternative treatment, about 50% of them die from CVD and its cardiovascular-related complications, which is significantly higher than that of the general population. Death due to infection or sepsis (about 15%). According to the survey of CRF patients in Shanghai in my country, 86.0% of CRF patients had various types of CVD complications (mainly ischemic ST-T changes, heart failure, arrhythmia, etc.), and the re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P13/12A61P9/00A61K35/32
Inventor 何立群杨雪军
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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