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Canton love-pea vine total flavone c-glycosides effective part, preparation method and use thereof

A kind of technology of total flavonoid carbon glycosides and hairy chicken bone grass, which is applied in the preparation of medicines for the prevention and treatment of acute and chronic hepatitis and related diseases, the field of effective parts of total flavonoid carbon glycosides

Inactive Publication Date: 2008-08-27
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Extraction and isolation of a total flavonoid carbon glycoside effective part from the traditional Chinese medicine Phyllostachys japonicus, and its use in the preparation of drugs for the prevention and treatment of acute and chronic hepatitis and related diseases, no literature reports

Method used

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  • Canton love-pea vine total flavone c-glycosides effective part, preparation method and use thereof
  • Canton love-pea vine total flavone c-glycosides effective part, preparation method and use thereof
  • Canton love-pea vine total flavone c-glycosides effective part, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of total flavonoid carbon glycosides extract from Jigucao

[0030] Take 1Kg of chicken bone herbal medicine, add 70% ethanol to reflux and extract twice, combine the alcohol extracts, recover under reduced pressure until there is no alcohol smell, centrifuge, and put the supernatant on the treated D101 macroporous adsorption resin column after adsorption , followed by elution with 3 liters of deionized water and 5 liters of 50% ethanol, collecting the 50% ethanol eluate, and evaporating to dryness under reduced pressure to obtain 21 g of total flavonoid glycosides extract of Chickweed. Using HPLC-UV method for quantitative analysis, apigenin-6,8-diC-glucoside, apigenin-6-C-glucose-8-C-arabinoside and apigenin-6-C-arabinose-8- The contents of C-glucoside were 17.0%, 15.1%, and 19.6%, respectively.

Embodiment 2

[0032] Preparation of total flavonoid carbon glycosides extract from Jigucao

[0033] Add 10 times the amount of 95% ethanol to the extract obtained in Example 1, heat and reflux for extraction for 1 hour, and suction filter while it is hot. The filtrate is recovered from ethanol and then vacuum-dried to obtain a high-purity total flavonoid glycosides extract of Chickweed. Using HPLC-UV method for quantitative analysis, apigenin-6,8-diC-glucoside, apigenin-6-C-glucose-8-C-arabinoside and apigenin-6-C-arabinose-8- The contents of C-glucoside were 20.0%, 17.5%, and 25.6%, respectively.

Embodiment 3

[0035] Preparation of total flavonoid carbon glycosides extract from Jigucao

[0036] Add 10 times the amount of 75% ethanol to the extract obtained in Example 1, heat and reflux for extraction for 1 hour, and suction filter while it is hot. The filtrate is recovered from ethanol and then vacuum-dried to obtain a high-purity total flavonoid glycosides extract of Chickweed. Using HPLC-UV method for quantitative analysis, apigenin-6,8-diC-glucoside, apigenin-6-C-glucose-8-C-arabinoside and apigenin-6-C-arabinose-8- The contents of C-glucoside were 22.0%, 15.5%, and 24.3%, respectively.

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Abstract

The invention relates to a total flavone c-glycoside effective component extract separated from traditional Chinese medicine abrus mollis hance, belonging to natural medicine technical field, which mainly contains apigenin-6, 8-bis-C-glucoside, apigenin-6-C-glucose-8-C-arabinfuranoside and apigenin-6-C-arabinose-8-C-glucoside, whose flavone c-glycoside content is higher than 40%. The invention relates to an extraction method of the total flavone c-glycoside effective component extract. Pharmacodynamic tests prove that the abrus mollis hance total flavone c-glycoside extract can be used as active component to prepare the drugs for the prevention and treatment of acute and chronic hepatitis or the like.

Description

technical field [0001] The invention belongs to the field of natural medicines, and in particular relates to a total flavonoid carbon glycoside effective fraction extracted and separated from the traditional Chinese medicine Phyllostachys japonicus, its preparation method and its application in the preparation of medicines for preventing and treating acute and chronic hepatitis and related diseases. Background technique [0002] Liver disease is one of the common infectious diseases and frequently-occurring diseases that seriously threaten human health. According to the etiology, it can be divided into viral hepatitis, autoimmune hepatitis, drug-induced hepatitis, alcoholic hepatitis, non-alcoholic fatty liver, genetic metabolic liver disease and Hepatitis caused by other infectious agents. Among hepatitis, viral hepatitis is the most harmful to human beings, and among viral hepatitis, hepatitis B and C are particularly prominent. Hepatitis B is a worldwide disease. There a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07A61K31/7048A61K36/48A61P1/16
Inventor 汪豪张陆勇江振洲刘卓伟熊非叶文才赵守训
Owner CHINA PHARM UNIV
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