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Oral paste with blood glucose reducing function and preparation method thereof

A blood sugar-lowering, functional technology, applied in the field of ointment with hypoglycemic function, can solve the problems of large ethanol, consumption, and many operation steps, and achieve the effect of mild reaction, wide source of raw materials, and reduced side effects

Inactive Publication Date: 2019-05-21
HUNAN BUTIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both of the above two processes require secondary alkalization and ethanol reaction system, and there are many operation steps and consume a large amount of ethanol

Method used

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  • Oral paste with blood glucose reducing function and preparation method thereof
  • Oral paste with blood glucose reducing function and preparation method thereof
  • Oral paste with blood glucose reducing function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Described carboxymethyl pachyrhin is prepared by following method:

[0034] S1. Cultivation of Poria cocos: aseptically inoculate Poria cocos hyphae in wort juice liquid medium, and cultivate at 28°C for 4 days;

[0035] S2. Preparation of Poria cocos polysaccharide: Ferment the cultured Poria cocos medium at 35°C for 2 days, heat to a slight boil, extract for 1 hour, filter, add 3 times the amount of mixed solvent of chloroform and n-butanol, the chloroform and n-butanol The mixed volume ratio is 4:1, shaken, centrifuged, add 3 times the amount of 95% ethanol, overnight, filter to obtain a precipitate, wash 2 times with ether to obtain pachyman;

[0036] S3. Preparation of Poria Cocos Polysaccharide: Add 10g of Poria cocos polysaccharide into 100mL0.5mol / L sodium periodate solution for selective oxidation, adjust the pH value to 3 with trifluoroacetic acid, moderate acid hydrolysis, acid hydrolysis time is 30min, filter , washing the solid with water to obtain Poria c...

Embodiment 2

[0040] Described carboxymethyl pachyrhin is prepared by following method:

[0041] S1. Cultivation of Poria cocos: aseptically inoculate Poria cocos hyphae in wort liquid culture medium, and cultivate at 28° C. for 5 days;

[0042] S2. Preparation of Poria cocos polysaccharide: Ferment the cultured Poria cocos medium at 35°C for 2 days, heat to a slight boil, extract for 2 hours, filter, add 5 times the volume of a mixed solvent of chloroform and n-butanol, the chloroform and n-butanol The mixed volume ratio is 6:1, shaken, centrifuged, add 3 times the amount of 95% ethanol, overnight, filter to obtain a precipitate, wash 3 times with ether to obtain pachymane;

[0043] S3. Preparation of Poria Cocos Polysaccharide: Add 10g of Poria cocos polysaccharide into 30mL 1.5mol / L sodium periodate solution for selective oxidation, adjust the pH value to 4 with trifluoroacetic acid, moderate acid hydrolysis, acid hydrolysis time is 1h, filter , washing the solid with water to obtain Po...

Embodiment 3

[0047] Described carboxymethyl pachyrhin is prepared by following method:

[0048] S1. Cultivation of Poria cocos: aseptically inoculate Poria cocos hyphae in wort juice liquid medium, and cultivate at 28°C for 4 days;

[0049] S2. Preparation of Poria cocos polysaccharide: Ferment the cultured Poria cocos medium at 35°C for 2 days, heat to a slight boil, extract for 2 hours, filter, add a mixed solvent of chloroform and n-butanol, the mixing volume ratio of chloroform and n-butanol 5:1, shake, centrifuge, add 3 times the amount of 95% ethanol, overnight, filter to get precipitate, wash 3 times with diethyl ether to obtain pachyrhin;

[0050] S3. Preparation of Poria Cocos Polysaccharide: Add 10g of Poria cocos polysaccharide into 50mL 1.0mol / L sodium periodate solution for selective oxidation, adjust the pH value to 3.6 with trifluoroacetic acid, moderate acid hydrolysis, acid hydrolysis time is 45min, filter , washing the solid with water to obtain Poria cocos polysaccharid...

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Abstract

The invention provides oral paste with a blood glucose reducing function. The oral paste is prepared from, by weight, 45-50 parts of carboxymethyl pachymaran, 20-30 parts of cyclocarya paliurus leaves, 12-17 parts of inulin, 3-8 parts of earthworm protein, 20-30 parts of camellia chrysantha, 20-30 parts of fructus lycii, 20-30 parts of cinnamon, 20-30 parts of Chinese yam, 30-40 parts of rhizoma polygonati, 20-30 parts of radix puerariae, 10-15 parts of stigma maydis and 0.5-1 part of stevioside. The raw materials are wide in source, a preparation method is simple, the prepared oral paste hasthe effects of obviously reducing blood glucose, urine glucose, blood lipid and glycosylated hemoglobin, improving the insulin function, controlling blood lipid, enhancing immunity and the like, and has wide application prospects.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine health care, in particular to a cream with the function of lowering blood sugar. Background technique [0002] Diabetes is a disease that seriously endangers human health. According to statistics, the incidence rate of diabetes in the world is 3% to 5%, and the average incidence rate of people over 50 years old is 10%. In the United States, more than 160,000 people die each year from complications of diabetes. In my country, with the development of the economy, the change of people's diet structure and the aging of the population, the number of diabetic patients is increasing rapidly. [0003] Diabetes is a lifelong disease whose severity lies in the high incidence of complications. Studies in the United States have shown that 95% of patients with diabetes for more than 20 years have retinopathy, and diabetic patients die of cardiovascular disease. In addition, diabetic pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61K31/715A61K36/899A61K9/06A61P3/10A61P3/06A61P5/50A61P37/04C08B37/02
Inventor 孙梦锦戴鑫汶戴甲木龙孝金邹奇唐心文张豪
Owner HUNAN BUTIAN PHARMA
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