A liver-protecting japonicus traditional Chinese medicine oral liquid and preparation method thereof

A technology of traditional Chinese medicine oral liquid and sea cucumber enzymolysis liquid, which is applied in the directions of pharmaceutical formulation, drug combination, drug delivery, etc., can solve the problem of not finding liver-protecting preparations, and achieve outstanding liver-protecting effects, improve immunity, reduce The effect of transaminases

Active Publication Date: 2019-03-08
SHANDONG HOMEY AQUATIC DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the preparation of liver-protecting preparations using sea cucumber as a raw material and other traditional Chinese medicines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of liver-protecting japonicus japonicus traditional Chinese medicine oral liquid, through the following process steps:

[0023] (1) Preparation of sea cucumber enzymatic hydrolyzate

[0024] Select fresh sea cucumbers as raw materials, remove the viscera of sea cucumbers, wash them, take the body wall of sea cucumbers and blanch them with hot water at 80°C, add distilled water, use a colloid mill to grind them into a slurry, and prepare sea cucumbers with a protein concentration of 15%. ginseng solution; heat the sea cucumber solution to 95°C, keep it for 20min, then cool to 50°C, add compound protease with a solution weight of 5‰ to hydrolyze for 2 hours, and then add flavor protease with a solution weight of 6‰ to hydrolyze for 2 hours; after hydrolysis, heat to Keep at 95°C for 25 minutes to inactivate the enzyme; after inactivating the enzyme, quickly cool to 4°C to prepare the sea cucumber enzymatic hydrolyzate; among them, the complex protease...

Embodiment 2

[0031] A preparation method of liver-protecting japonicus japonicus traditional Chinese medicine oral liquid, through the following process steps:

[0032] (1) Preparation of sea cucumber enzymatic hydrolyzate

[0033]Select fresh sea cucumbers as raw materials, remove the viscera of sea cucumbers, wash them, take the body wall of sea cucumbers and blanch them with hot water at 90°C, add distilled water, use a colloid mill to grind them into a slurry, and prepare sea cucumbers with a protein concentration of 20%. ginseng solution; heat the sea cucumber solution to 100°C, keep it for 10 minutes, then cool it to 55°C, add a compound protease with a solution weight of 4‰ to hydrolyze for 3 hours, and then add a flavor protease with a solution weight of 7‰ to hydrolyze for 1 hour; after hydrolysis, heat to Keep at 100°C for 20 minutes to inactivate the enzyme; after inactivating the enzyme, cool it down to 5°C quickly to prepare the sea cucumber enzymatic hydrolysis solution; amon...

Embodiment 3

[0040] A preparation method of liver-protecting japonicus japonicus traditional Chinese medicine oral liquid, through the following process steps:

[0041] (1) Preparation of sea cucumber enzymatic hydrolyzate

[0042] Select fresh sea cucumbers as raw materials, remove the viscera of sea cucumbers, wash them, take the body wall of sea cucumbers and blanch them with hot water at 85°C, add distilled water, grind them into a slurry with a colloid mill, and prepare sea cucumbers with a protein concentration of 10%. ginseng solution; heat the japonicus japonicus solution to 90°C, keep it for 30 minutes, then cool it to 40°C, add a compound protease with a solution weight of 7‰ to hydrolyze for 1 hour, and then add a flavor protease with a solution weight of 4‰ to hydrolyze for 3 hours; after hydrolysis, heat to Keep at 90°C for 30 minutes to inactivate the enzyme; after inactivating the enzyme, quickly cool to 3°C to prepare the sea cucumber enzymatic hydrolyzate; among them, the ...

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Abstract

The invention relates to a liver-protecting stichopus japonicus traditional Chinese medicine oral solution and a preparation method thereof. The method comprises the following steps: blanching and homogenating the wall of a stichopus japonicus body, carrying out controlled enzyme hydrolysis sequentially by compound protease and flavourzyme, deactivating enzyme, and cooling to prepare a stichopus japonicus enzymatic hydrolysate; preparing a substrate raw material from schisandra chinensis, fructus lycii and chrysanthemum indicum, obtaining a water extract by using a hot-water decoction method, removing precipitate with ethanol, distilling supernate to remove ethanol, and adding pure water to prepare a traditional Chinese medicine extract; mixing the stichopus japonicus enzymatic hydrolysate and the traditional Chinese medicine extract, preparing, concentrating, centrifuging to obtain supernate, adding auxiliaries, uniformly stirring, and sequentially carrying out UHT sterilization, hot filling and secondary sterilization to prepare the liver-protecting stichopus japonicus traditional Chinese medicine oral solution. The liver-protecting stichopus japonicus traditional Chinese medicine oral solution is scientific in formula, sour and sweet, tastes delicious, has the effects of soothing-liver, regulating qi, clearing heat, removing toxicity, calming the liver and tranquilizing, and has double functions of health protection and nourishing. The preparation method is reasonable in process and feasible in operation, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a pharmaceutical preparation with an undetermined structure of traditional herbal medicine, in particular to a liver-protecting japonicus traditional Chinese medicine oral liquid and a preparation method thereof. Background technique [0002] With the development of society and the improvement of living standards, the number of people facing liver injury is increasing. Excessive drinking, drug abuse, and a fatty diet are all triggers of liver damage. How to protect the liver has become an urgent problem to be solved. [0003] Sea cucumber, also known as sea cucumber, sea rat, sea cucumber, etc., is a rare marine animal, named for its tonic effect similar to ginseng. Sea cucumber is not only a precious food, but also a valuable medicinal material. According to the records in "Compendium of Materia Medica": Sea cucumbers are sweet and salty, tonify the kidneys, benefit the essence, take urine, aphrodisiac and treat impotence. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/815A61K9/08A61P1/16A23L33/00A61K35/616
CPCA23V2002/00A61K9/08A61K35/616A61K36/287A61K36/57A61K36/79A61K36/815A61K2236/19A61K2236/331A61K2236/55A61K2300/00A23V2200/30A23V2200/324A23V2250/21
Inventor 孙玥袁文鹏胡炜孙永军王志伟张泮池王昌伟邹志海鞠文明唐晓波
Owner SHANDONG HOMEY AQUATIC DEV
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