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Externally-applied drug delivery preparations containing bullatacin part medicine exquisite articles

A technology of parts and products, applied in the field of topical drug delivery preparations containing blastatine part medicines, can solve problems such as toxic and side effects, and achieve the effects of less damage to normal cells, reduction of drug dosage, and improvement of related complications

Inactive Publication Date: 2008-09-10
贵州正鑫实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide an external administration preparation containing bratasine local drug essence, which solves the disadvantages of oral or intravenous administration of anti-tumor and anti-HIV drugs in the past.

Method used

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  • Externally-applied drug delivery preparations containing bullatacin part medicine exquisite articles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Get 6 kg of washed and dried custard apple seeds and pulverize them to 40-50 meshes, add 95% alcohol to soak and extract for 18-20 hours (repeated 4 times), concentrate under reduced pressure to recover the alcohol, add 800 ml each of water and petroleum ether Fully shake, after standing for stratification, back extraction with 78% alcohol (800ml each time, repeated 6 times), after standing for stratification, release the lower layer stripping solution (5600ml), after decompression and recovery of alcohol, to obtain 180g of total lactones in custard apple. Mix well with 270g of silica gel (100-200 mesh) and total annona lactones, then dry it and set aside. Use 450g of silica gel (100-200 mesh) to dry-pack the column, then add the prepared mixed sample silica gel for column chromatography, and use petroleum ether-acetone mixture (95:5, 92:8, 90:10, 88: 12) Elution with the eluent, collect and recover acetone and petroleum ether, and combine the required activ...

Embodiment 2

[0021] Dissolve 198g of local medicinal products containing bullatacin in 1100ml of a mixture of absolute ethanol and propylene glycol (volume ratio 1:1), stir thoroughly to mix the medicine and the mixture evenly, and follow the paste 20400 patches (size: 7×10cm) were made by using the production method of the patch.

Embodiment 3

[0023] Dissolve 168g of the local drug essence containing bullatacin in 1200ml of a mixed solution of absolute ethanol and propylene glycol (volume ratio is 1:1), stir well, and after the medicine and the mixed solution are completely mixed, follow the gas The production method of spray and film is made into aerosol and film.

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PUM

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Abstract

The invention discloses a drug delivery system for external use containing the effective composition of bullatacin locality drug; the effective composition containing the bullatacin locality drug is dissolved in a mixed liquid of absolute alcohol and propylene glycol and fully stirred and mixed, and then prepared into the drug delivery system for external use; the drug delivery system comprises a patch, an aerosol or a film agent. Adoptions of the natural substance bullatacin extracted from cherimoya and an external using manner of the invention overcomes the shortcoming that the antitumor drugs and anti-AIDS drug have to be orally used or intravenously medicated, and the drug delivery system can ensure the drug to be absorbed through the skin, thus slowly releasing the drug and reducing the delivery dosage of the drug and the economic cost for the treatment.

Description

technical field [0001] The invention relates to a preparation for external use, in particular to a preparation for external use containing buratasine local drug essence. Background technique [0002] Annonaceae (Annonaceae) is a large plant group in tropical and subtropical regions, which contains alkaloids, terpenoids, flavonoids, annonaceae, polyoxycyclohexenes and styrylactones. Among them, the latter three types of compounds have anti-tumor activity, and have aroused widespread interest of scholars from various countries. Annonaceous acetogenins (annonaceous acetogenins) were first discovered in 1982 in Annonaceae plants (Annonaceae) a new class of new natural products. Annonaceolide has a wide range of physiological activities, the most typical of which are anti-tumor activity and cytotoxicity. Studies have shown that most annona lactones generally have a strong cytotoxic effect on tumor cells cultured in vitro. [0003] In addition, anemone lactone can overcome mult...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K9/12A61K31/365A61P35/00A61P31/12
Inventor 杨正强杨仁洲脱冰林周显勇张安袁胜伟
Owner 贵州正鑫实业有限公司
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