Anti-worm formulation
An anti-helminth and preparation technology, which is applied in biocides, anti-infection drugs, animal repellents, etc., can solve the difficulty of triclabendazole in pouring preparations due to the dissolution characteristics of triclabendazole, and can not effectively treat liver tablets Trematodes and other issues
Active Publication Date: 2008-11-26
BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC
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Problems solved by technology
However, as mentioned earlier, these anthelmintics are not effective in treating early immature and mature Fasciola hepatica
The solubility characteristics of triclabendazole make it extremely difficult to prepare effective pour-on formulations of triclabendazole
Method used
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This invention relates to the preparation of veterinary anthelmintic formulations including triclabendazole in solution, particularly for the treatment of parasitic infections such as fasciolisis, and particularly for administration to an animal in the form of a pour-on. The solutions include triclabendazole dissolved in a solvent system including at least one solvent selected from 2-pyrrolidone and liquid polyethylene glycol. Additional solvents may also be included. The present invention is advantageous as triclabendazole can be included in solution up to a concentration of about 60% w / v allowing for an effective dose to be delivered to the animal in a volume of 25 ml or less.
Description
anti-helminth preparations field of invention The present invention relates to liquid solutions of triclabendazole, and in particular to veterinary anthelmintic formulations comprising liquid solutions of triclabendazole, which have particular, though not exclusive, application as liquid pour-on formulations. Background of the invention Diseases caused by parasitic worms such as nematodes, tapeworms and trematodes (liver flukes) can cause serious economic losses on farms of ruminants and other animals. Fascioliasis is a disease caused by a parasitic liver fluke that commonly infects domesticated herbivores such as sheep, cattle, and goats. The liver flukes Fasciola hepatica and Fasciola large are flatworms that live in the bile ducts (in the liver) of their hosts. Fasciola hepatica infection is widespread and is generally associated with low-lying moist or water-covered areas. Areas with an average annual rainfall of or above about 600 mm, especially irrigated areas, cr...
Claims
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IPC IPC(8): A61K31/4184A61K9/08A01N43/52A01N43/04A61P33/10
CPCA61K31/4184A01N43/52A61K9/0017A61K47/10A61K47/22A61P33/00A61P33/10A01N25/02A01N2300/00A61K9/08
Inventor M·H·A·拉扎克
Owner BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC