Method for improving dissolution rate of triclabendazole particles and dissolution rate detection method of triclabendazole particles

A technology of triclabendazole and detection method, which is applied to a method for improving the dissolution rate of triclabendazole granules and the field of dissolution detection thereof, and can solve the problems of low dissolution rate of triclabendazole and the like

Pending Publication Date: 2021-08-31
JIANGXI BOLAI PHARMACY CO LTD
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is in order to solve the defect in the prior art, provides a kind of composite solution as wetting agent, surfactant and binding agent to change the dispersibility of triclabendazole, improve its drug dissolution rate, solve three problems The problem of the low dissol

Method used

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  • Method for improving dissolution rate of triclabendazole particles and dissolution rate detection method of triclabendazole particles
  • Method for improving dissolution rate of triclabendazole particles and dissolution rate detection method of triclabendazole particles
  • Method for improving dissolution rate of triclabendazole particles and dissolution rate detection method of triclabendazole particles

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Embodiment Construction

[0025] In order to have a further understanding and understanding of the structural features of the present invention and the achieved effects, the preferred embodiments and accompanying drawings are used for a detailed description, as follows:

[0026] A method for improving the dissolution rate of triclabendazole granules, the specific steps are:

[0027] (1) After screening experiments, the present invention uses triclabendazole, starch and glucose in a ratio of 1:1:8 as the main body of the prescription;

[0028] (2) Add 1 part of starch to 9 parts of water, use steam to make a uniform starch slurry, let it cool, and set aside;

[0029] (3) Add 0.5 part of sodium carboxymethyl cellulose to 99.5 parts of water, stir and dissolve to a clear solution, and set aside;

[0030] (4) Mix water, 95% ethanol, sorbitan monooleate and polyvinylpyrrolidone K30 in a ratio of 3:6:0.4:0.6, stir and dissolve until a clear and uniform solution is set aside;

[0031] (5) Mix triclabendazol...

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Abstract

The invention discloses a method for improving the dissolution rate of triclabendazole particles and a dissolution rate detection method of the triclabendazole particles. The method comprises the following steps: firstly, mixing water, 95% ethanol, sorbitan monooleate and polyvinylpyrrolidone K30 according to a ratio of 3: 6: 0.4: 0.6, stirring and dissolving to obtain a clear and uniform composite solution for later use; then mixing triclabendazole, starch and glucose in a high-speed mixing pot according to a ratio of 1: 1: 8 for 5 minutes, slowly adding the mixture into the composite solution in the step S1 according to a ratio of 5% by adopting a method of stirring while adding, and then mixing for 5-10 minutes to prepare a soft material; and finally, feeding the soft material to a granulator, granulating with a 18-mesh screen, collecting, and drying in a drying oven. Compared with the prior art, the method for preparing the triclabendazole granules by using the composite solution has the advantages that the drug dissolution rate of the triclabendazole granules is improved, and the triclabendazole granules prepared from water, 95% ethanol, sorbitan monooleate and polyvinylpyrrolidone K30 according to the ratio of 3: 6: 0.4: 0.6 have the best dissolution rate.

Description

technical field [0001] The invention relates to the technical field of chemical drug preparations, in particular to a method for improving the dissolution rate of triclabendazole granules and a method for detecting the dissolution rate thereof. Background technique [0002] Triclobendazole (Triclabendazole, TCBZ) is a class of benzimazole derivatives developed and produced by Ciba-Geigy (Ciba-Geigy) pharmaceutical factory in Switzerland in the 1980s. It has been used in veterinary practice since 1983. It is mainly used to control the infection of Fasciola hepatica in sheep and cattle. This product is white to off-white crystalline powder, odorless, has a slight aroma, is insoluble in water, is a hydrophobic drug, is not easy to disperse in water, and needs to pass some Process technology means to improve its bioavailability. [0003] Fasciola hepatica is a common parasite that parasitizes in the bile ducts of cattle, sheep and dozens of mammals. It is sporadic and prevalent...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/4184A61K47/10A61K47/26A61K47/32A61K47/36A61K47/38A61K47/22A61P33/10
CPCA61K9/1694A61K9/1635A61K9/1652A61K9/1623A61K9/1617A61K31/4184A61P33/10G01N33/15
Inventor 肖兴丽唐进波肖欣戈胡国彬陈齐杰陈俞庆夏薇刘京京周子龙
Owner JIANGXI BOLAI PHARMACY CO LTD
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