Method for improving dissolution rate of triclabendazole particles and dissolution rate detection method of triclabendazole particles

Abstract

The invention discloses a method for improving the dissolution rate of triclabendazole particles and a dissolution rate detection method of the triclabendazole particles. The method comprises the following steps: firstly, mixing water, 95% ethanol, sorbitan monooleate and polyvinylpyrrolidone K30 according to a ratio of 3: 6: 0.4: 0.6, stirring and dissolving to obtain a clear and uniform composite solution for later use; then mixing triclabendazole, starch and glucose in a high-speed mixing pot according to a ratio of 1: 1: 8 for 5 minutes, slowly adding the mixture into the composite solution in the step S1 according to a ratio of 5% by adopting a method of stirring while adding, and then mixing for 5-10 minutes to prepare a soft material; and finally, feeding the soft material to a granulator, granulating with a 18-mesh screen, collecting, and drying in a drying oven. Compared with the prior art, the method for preparing the triclabendazole granules by using the composite solution has the advantages that the drug dissolution rate of the triclabendazole granules is improved, and the triclabendazole granules prepared from water, 95% ethanol, sorbitan monooleate and polyvinylpyrrolidone K30 according to the ratio of 3: 6: 0.4: 0.6 have the best dissolution rate.

Description

technical field [0001] The invention relates to the technical field of chemical drug preparations, in particular to a method for improving the dissolution rate of triclabendazole granules and a method for detecting the dissolution rate thereof. Background technique [0002] Triclobendazole (Triclabendazole, TCBZ) is a class of benzimazole derivatives developed and produced by Ciba-Geigy (Ciba-Geigy) pharmaceutical factory in Switzerland in the 1980s. It has been used in veterinary practice since 1983. It is mainly used to control the infection of Fasciola hepatica in sheep and cattle. This product is white to off-white crystalline powder, odorless, has a slight aroma, is insoluble in water, is a hydrophobic drug, is not easy to disperse in water, and needs to pass some Process technology means to improve its bioavailability. [0003] Fasciola hepatica is a common parasite that parasitizes in the bile ducts of cattle, sheep and dozens of mammals. It is sporadic and prevalent...

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Problems solved by technology

[0007] The purpose of the present invention is in order to solve the defect in the prior art, provides a kind of composite solution as wetting agent, surfactant and binding agent to change the dispersibility of triclabendazole, improve its drug dissolution rate, solve three problems The problem of the low dissolution rate of clobendazole was obtained through dissolution analysis. When the ratio of water, 95% ethanol, sorbitan monooleate and polyvinylpyrrolidone K30 was 3:6:0.4:0.6, The method for improving the dissolution rate of triclabendazole granules with the best dissolution rate and its dissolution testing method

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