Meisuoshuli suppository, and preparation method and use thereof

A technology for mesosol suppositories and suppositories, applied in the field of medicine, can solve the problems of poor medication compliance of patients, inconvenience of patients taking tablets, difficulty in taking tablets, etc., to avoid first-pass effect, avoid gastrointestinal side effects, and inhibit bacterial autogenesis. effect of ability

Inactive Publication Date: 2016-03-30
WUHAN OPTICS VALLEY HUMANWELL BIO PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mesosulide is a non-steroidal anti-inflammatory drug (NSAID for short), which can be prepared into tablets, but it is difficult to take tablets for children and elderly patients, or for patients who cannot swallow or have difficulty swallowing , leading to poor drug compliance in patients
Mesosulide has a slightly bitter taste. If it cannot solve the taste problem, it will also cause inconvenience to patients.
[0003] At present, research on mesosulide preparations still needs to be strengthened

Method used

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  • Meisuoshuli suppository, and preparation method and use thereof
  • Meisuoshuli suppository, and preparation method and use thereof
  • Meisuoshuli suppository, and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1, the preparation of methosulide suppository

[0041] In the present embodiment, the prescription and preparation process of mesosulide suppository are studied:

[0042] 1. Screening of suppository base

[0043] The suppository base is the key to suppository molding. The selected base must meet the requirements of easy mixing of drugs, injection molding, molding, good appearance of the finished suppository, and compliance with the pharmacopoeia for the melting time limit. Specifically, in this test, the appearance of the suppository, the time limit for melting, and the dissolution rate of mesosulide in 1 hour were used as evaluation indicators. A kind of, or the combination of glycerin gelatin and a kind of mixed fatty acid glycerides is screened, wherein, when the suppository base is the combination of glycerin gelatin and a kind of mixed fatty acid glycerides, the ratio of glycerin gelatin and mixed fatty acid glycerides is selected as 1 : 1, the screeni...

Embodiment 2

[0076] Embodiment 2: the preparation of methosulide suppository

[0077] 1) Prescription:

[0078]

[0079] 2) Preparation method:

[0080] Micronize the prescribed amount of mesosulide raw materials to a particle size of 30-60 microns, add liquid paraffin and mix thoroughly to obtain mixture 1; Mix fatty acid glycerides, heat and melt in a water bath at 50°C, add to the above mixture 1, continue stirring and mixing, add isopropyl myristate, and ethylparaben, mix, and stir well to obtain mixture 2. Pour the above mixture 2 into the plug mold which has been cooled and coated with an appropriate amount of lubricant until it slightly overflows the die opening. After cooling at room temperature for 30 minutes to completely solidify, cut off the overflowing part with a knife, open the model, push out the suppository, and pack it in a double-layer low-density polyethylene film bag to obtain the mesosulide suppository.

Embodiment 3

[0081] Embodiment 3: the preparation of mesosulide suppository

[0082] 1) Prescription:

[0083]

[0084] 2) Preparation method

[0085] Micronize the prescribed amount of mesosulide raw materials to a particle size of 10-30 microns, add liquid paraffin and mix thoroughly to obtain mixture 1; Mix fatty acid glycerides, heat and melt in a water bath at 40°C, add to the above mixture 1, continue to stir and mix, add isopropyl myristate, and ethylparaben, mix, and stir well to obtain a mixture 2. The mixture 2 is poured into the plug mold that has been cooled and coated with an appropriate amount of lubricant until it overflows the die opening slightly. After cooling at room temperature for 30 minutes to completely solidify, cut off the overflowing part with a knife, open the model, push out the suppository, and pack it in a double-layer low-density polyethylene film bag to obtain the mesosulide suppository.

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Abstract

The invention provides a Meisuoshuli suppository, and a preparation method and a use thereof. The Meisuoshuli suppository comprises Meisuoshuli and pharmaceutically acceptable auxiliary materials. The Meisuoshuli suppository has high dissolution rate and no irritation, has very good fever relieving, pain easing and inflammation preventing effects, has the advantages of large drug load, small administration frequency, simple use, low price, economy and practicality, and is very convenient for old people, children or unable oral administration patients to administrate.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a mesosulide suppository and a preparation method and application thereof. Background technique [0002] Mesosulide is the world's first Class 1.1 new chemical drug jointly developed by the Academy of Military Medical Sciences and Humanwell Pharmaceutical Group. Mesosulide is a non-steroidal anti-inflammatory drug (NSAID for short), which can be prepared into tablets, but it is difficult to take tablets for children and elderly patients, or for patients who cannot swallow or have difficulty swallowing , leading to poor medication adherence by patients. Mesosulide has a slightly bitter taste, and if it cannot solve the taste problem, it will also cause inconvenience to patients when taking it. [0003] At present, research on mesosulide preparations still needs to be strengthened. Contents of the invention [0004] The present invention aims to solve one of the technical problems in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K31/18A61P29/00
Inventor 王学海李莉娥许勇廖娟娟黄怡黄璐涂荣华杨仲文乐洋江曦朱垒余艳平刘荃王伟田华肖强范昭泽杨菁张毅
Owner WUHAN OPTICS VALLEY HUMANWELL BIO PHARMA
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