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Medicament composition containing amlodipine besylate and candesartan cilexetil and medicine box

A technology of amlodipine besylate and amlodipine besylate, which is applied in directions such as drug combinations, medical preparations containing active ingredients, and pharmaceutical formulations, can solve problems such as differences in dosage ratios and achieve good synergistic effects

Active Publication Date: 2009-02-25
ZHEJIANG YONGNING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it can be seen from these documents that different ratios of amlodipine and ARB have different synergistic effects, and the dosage ratio of amlodipine combined with different ARBs to achieve a better synergistic effect is also very different

Method used

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  • Medicament composition containing amlodipine besylate and candesartan cilexetil and medicine box

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 Compound pharmaceutical composition

[0028] prescription:

[0029] Amlodipine Besylate 5g

[0030] Candesartan cilexetil 5g

[0031] Lactose 80g

[0032] Sodium carboxymethyl starch 10g

[0033] Low-substituted hydroxypropyl cellulose 10g

[0034] 5% (w / v) povidone ethanol solution appropriate amount

[0035] Magnesium Stearate 1g

[0036] Made: 1000 pieces

[0037]Process: Raw and auxiliary materials are crushed and passed through a 100-mesh sieve; candesartan cilexetil and amlodipine besylate are taken, mixed thoroughly, added lactose in equal amounts, mixed fully again, and then mixed with sodium carboxymethyl starch, low-substituted Hydroxypropyl cellulose, mixed evenly; take povidone and ethanol, make a 5% (w / v) solution, granulate in the above-mentioned mixture of raw and auxiliary materials, pass through 16 mesh, and dry at 50-60°C; dry granules with 16 Mesh sieve for granulation, add magnesium stearate, and compress into tablets.

Embodiment 2

[0038] Embodiment 2 Compound pharmaceutical composition

[0039] prescription:

[0040] Amlodipine Besylate 5g

[0041] Candesartan cilexetil 10g

[0042] Lactose 80g

[0043] Sodium carboxymethyl starch 10g

[0044] Low-substituted hydroxypropyl cellulose 10g

[0045] 5% povidone ethanol solution appropriate amount

[0046] Magnesium Stearate 1g

[0047] Made: 1000 pieces

[0048] Technology: with embodiment 1.

Embodiment 3

[0049] Embodiment 3 Compound pharmaceutical composition

[0050] prescription:

[0051] Amlodipine Besylate 2.5g

[0052] Candesartan cilexetil 5g

[0053] Lactose 80g

[0054] Sodium carboxymethyl starch 10g

[0055] Low-substituted hydroxypropyl cellulose 10g

[0056] 5% povidone ethanol solution appropriate amount

[0057] Magnesium Stearate 1g

[0058] Made: 1000 pieces

[0059] Technology: with embodiment 1.

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PUM

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Abstract

The invention discloses a drug composition containing amlodipine besylate and candesartan cilexetil and a drug box thereof, wherein, the weight ratio of the amlodipine besylate to the candesartan cilexetil is 1:1-6. The compound drug has a better synergistic effect in reducing blood pressure and extending blood vessels, and can be used for curing cardiovascular diseases such as hypertension and coronary heart disease.

Description

technical field [0001] The present invention relates to a compound medicine of a calcium channel blocker (CCB) and angiotensin receptor blocker (ARB), in particular to a pharmaceutical composition containing amlodipine besylate and candesartan cilexetil and pillbox. Background technique [0002] Amlodipine (amlodipine) or its salts, such as amlodipine besylate (trade name Norvasc) is a new generation of dihydropyridine calcium channel blockers (CCB); and candesartan (candesartan) is An angiotensin receptor blocker (ARB) that efficiently binds AT 1 receptor, and AT 1 The receptor affinity is 80 times that of losartan, 20 times that of valsartan, and 3 times that of irbesartan. In order to improve bioavailability, candesartan is usually selected for oral preparations The prodrug of candesartan cilexetil. Both have the effects of lowering blood pressure and dilating blood vessels, and can be used to prevent and treat cardiovascular diseases such as hypertension, coronary he...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K31/4184A61P9/10A61P9/12
Inventor 叶凤起苏定冯宋书伟郑翔蒋正平
Owner ZHEJIANG YONGNING PHARMA
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