Hard capsule containing etodolac

A technology of etodolac and hard capsules is applied in the directions of capsule delivery, medical preparations containing active ingredients, organic active ingredients, etc., and can solve problems such as affecting drug release.

Inactive Publication Date: 2009-03-25
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, when using cheap and easy-to-get, widely used gelatin as the capsule shell, etodolac will cause cross-linking reaction of the gelatin in the capsule shell, affecting drug release. This is due to the fact that the cross-linked gelatin will Swells into a rubbery, water-insoluble film that acts as a barrier to limit drug release

Method used

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  • Hard capsule containing etodolac
  • Hard capsule containing etodolac
  • Hard capsule containing etodolac

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: With binder (wet granulation)

[0016]

[0017] Preparation Process

[0018] Mix etodolac, lactose and carboxymethyl starch sodium in a fast stirring granulator, add binders containing gelatin, povidone and sodium lauryl sulfate to granulate, add micropowder silica gel and stearic acid after drying Magnesium blend, fill capsules.

Embodiment 2

[0019] Embodiment 2: dry granulation

[0020]

[0021] Preparation Process

[0022] Mix etodolac, microcrystalline cellulose, gelatin and sodium starch glycolate evenly, dry granulate, add micropowder silica gel, mix evenly, and fill capsules.

Embodiment 3

[0023] Embodiment 3: (powder directly filling capsules)

[0024]

[0025] Preparation Process

[0026] After the etodolac, microcrystalline cellulose and gelatin are mixed evenly, then micropowder silica gel and magnesium stearate are added and mixed evenly, and the capsules are filled.

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Abstract

The invention relates to a hard capsule which contains etodolac, the substance in the capsule contains glutin as anti-crosslinking agent; the hard capsule which contains etodolac has the advantages of good stability, avoiding the crosslinking reaction on the capsule shell, being applicable to analgesia, diminishing inflammation and antipyretic.

Description

technical field [0001] The invention relates to a hard capsule containing etodolac, in particular to a hard capsule containing gelatin etodolac. Background technique [0002] Etodolac is currently the most popular NSAID (non-steroidal anti-inflammatory drug), used by more than 5 million people in the United States every year, and has 18 years of clinical safety drug experience in the world. Compared with traditional NSAIDs, etodolac has analgesic, anti-inflammatory and antipyretic effects 26-50 times stronger than aspirin and 2-2.5 times stronger than indomethacin; oral absorption is rapid, and the blood concentration is within 1-2 hours after taking it That is, it reaches the peak and eliminates quickly. And taking it for many times has no accumulation, and the adverse reaction is mild. Pharmacokinetics are not affected by age, so it is the first-line drug of choice for elderly patients. [0003] Etodolac selectively inhibits COX-2 and distributes the drug intensively in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/407A61P29/00
Inventor 李文斌
Owner BEIJING D VENTUREPHARM TECH DEV
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