Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Hard capsule containing etodolac

A technology of etodolac and hard capsules is applied in the directions of capsule delivery, medical preparations containing active ingredients, organic active ingredients, etc., and can solve problems such as affecting drug release.

Inactive Publication Date: 2009-03-25
BEIJING D VENTUREPHARM TECH DEV
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, when using cheap and easy-to-get, widely used gelatin as the capsule shell, etodolac will cause cross-linking reaction of the gelatin in the capsule shell, affecting drug release. This is due to the fact that the cross-linked gelatin will Swells into a rubbery, water-insoluble film that acts as a barrier to limit drug release

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hard capsule containing etodolac
  • Hard capsule containing etodolac
  • Hard capsule containing etodolac

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: With binder (wet granulation)

[0016]

[0017] Preparation Process

[0018] Mix etodolac, lactose and carboxymethyl starch sodium in a fast stirring granulator, add binders containing gelatin, povidone and sodium lauryl sulfate to granulate, add micropowder silica gel and stearic acid after drying Magnesium blend, fill capsules.

Embodiment 2

[0019] Embodiment 2: dry granulation

[0020]

[0021] Preparation Process

[0022] Mix etodolac, microcrystalline cellulose, gelatin and sodium starch glycolate evenly, dry granulate, add micropowder silica gel, mix evenly, and fill capsules.

Embodiment 3

[0023] Embodiment 3: (powder directly filling capsules)

[0024]

[0025] Preparation Process

[0026] After the etodolac, microcrystalline cellulose and gelatin are mixed evenly, then micropowder silica gel and magnesium stearate are added and mixed evenly, and the capsules are filled.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a hard capsule which contains etodolac, the substance in the capsule contains glutin as anti-crosslinking agent; the hard capsule which contains etodolac has the advantages of good stability, avoiding the crosslinking reaction on the capsule shell, being applicable to analgesia, diminishing inflammation and antipyretic.

Description

technical field [0001] The invention relates to a hard capsule containing etodolac, in particular to a hard capsule containing gelatin etodolac. Background technique [0002] Etodolac is currently the most popular NSAID (non-steroidal anti-inflammatory drug), used by more than 5 million people in the United States every year, and has 18 years of clinical safety drug experience in the world. Compared with traditional NSAIDs, etodolac has analgesic, anti-inflammatory and antipyretic effects 26-50 times stronger than aspirin and 2-2.5 times stronger than indomethacin; oral absorption is rapid, and the blood concentration is within 1-2 hours after taking it That is, it reaches the peak and eliminates quickly. And taking it for many times has no accumulation, and the adverse reaction is mild. Pharmacokinetics are not affected by age, so it is the first-line drug of choice for elderly patients. [0003] Etodolac selectively inhibits COX-2 and distributes the drug intensively in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/407A61P29/00
Inventor 李文斌
Owner BEIJING D VENTUREPHARM TECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com