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Medicine combination for treating coprostasis and preparation method thereof

A technology for treating constipation and composition, applied in the field of pharmaceutical composition for treating constipation and its preparation, can solve the problems of intestinal wall cell function and morphological changes, large intestinal epithelial damage, vicious cycle of laxative dependence, etc., and achieve strict compatibility , strong pertinence, exact effect

Active Publication Date: 2009-04-29
湖南时代阳光药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(3) Lubricating laxatives
It may also cause changes in the function and morphology of intestinal wall cells, thereby causing damage to the large intestinal epithelium
In addition, it may also cause a vicious cycle of dependence on such laxatives

Method used

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  • Medicine combination for treating coprostasis and preparation method thereof
  • Medicine combination for treating coprostasis and preparation method thereof
  • Medicine combination for treating coprostasis and preparation method thereof

Examples

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preparation example Construction

[0020] Preparation of Chinese patent medicine pharmaceutical composition

[0021] When the pharmaceutical composition of the present invention is a form of Chinese patent medicine made from the above-mentioned Chinese medicinal materials, it is preferably extracted with ethanol, water or a mixture of alcohol and water. In the present invention, the aloe does not need to be extracted, and can be directly added to the extracts of other plant components after being pulverized into powder. The extraction may be decocting or refluxing in an appropriate amount of water, ethanol or alcohol-water mixture after mixing various medicinal materials except aloe according to the aforementioned proportions. In this case, the extraction is usually by boiling 4 to 14 times by weight, preferably 5 to 12 times by weight, more preferably 5 to 10 times by weight of solvent for 1 to 3 hours. In the case of using alcohol aqueous solution as the extraction solvent, preferably 60-80% (weight ratio)...

Embodiment 1

[0035] 5 parts by weight of aloe is ground into fine powder for subsequent use. 10 parts by weight each of angelica, peach kernel, hemp seed, and cassia seed, add 70% ethanol for reflux extraction twice, add 6 times the amount of ethanol for reflux extraction for 2.0 hours for the first time; add 5 times the amount of ethanol for reflux for 1.5 hours for the second time, combine Extract the liquid, recover ethanol, concentrate under reduced pressure to an alcoholic extract with a relative density of 1.20 (measured at 60°C), and set aside. 24 parts by weight of Rehmannia glutinosa, 24 parts by weight of Scrophulariaceae, 7 parts by weight of Cistanche, 10 parts by weight of Fructus Citrus Citrus Fructus, add water and decoct twice, add 9 times the amount of water for the first time, decoct for 2.0 hours, the second time and the medicine after alcohol extraction Combine the slag, add 7 times the amount of water and decoct for 1.5 hours, combine the decoction, filter, and concent...

Embodiment 2

[0037] 3 parts by weight of aloe are ground into fine powder for subsequent use. Each 11 parts by weight of angelica, peach kernel, hemp seed, cassia seed, add 65% ethanol reflux extraction twice, add 7 times of ethanol reflux extraction 2.0 hours for the first time; Add 5 times of ethanol reflux 1.5 hours for the second time, combine alcohol Extract the liquid, recover ethanol, concentrate under reduced pressure to an alcoholic extract with a relative density of 1.20 (measured at 60°C), and set aside. Add 18 parts by weight of Rehmannia glutinosa, 25 parts by weight of Scrophulariaceae, 11 parts by weight of Cistanche, and 7 parts by weight of Citrus aurantium, add water and decoct twice, add 10 times the amount of water for the first time, and decoct for 2.0 hours. Combine the slag, add 7 times the amount of water and decoct for 1.5 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to an extract with a relative density of 1.20 (60°C th...

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Abstract

The invention provides a drug combination for the treatment of constipation and a preparation method thereof. The drug combination is prepared by Chinese herbal medicines comprising the following components according to parts by weight: 18 portions to 25 portions of radices rehmanniae, 18 portions to 25 portions of radix scrophularise, 6 portions to 11 portions of angelica, 6 portions to 11 portions of semen persicae, 6 portions to 11 portions of broomrape, 6 portions to 11 portions of fructus cannabis, 6 portions to 11 portions of semen cassiae torae, 6 portions to 11 portions of fructus aurantii immaturus and 3 portions to 6 portions of aloe. The drug combination can further contain proper excipients and other accessories. The drug combination provided by the invention has no vent hard goods with a plurality of side effects, such as rhubarb, thereby forming a more unique characteristic of application so as to realize the functions of nourishing yin and increasing the body fluid as well as loosing the bowel to relieve constipation.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating constipation and a preparation method thereof. Background technique [0002] Constipation is a clinically common disease. According to incomplete statistics, about 3% of young people and 20% of old people suffer from this disease, which seriously affects people's health and life. Its main manifestations are prolonged defecation intervals, dry and hard stools, or difficulty in expulsion despite the desire to defecate. Constipation is divided into functional and organic constipation, and functional constipation is more common clinically. After the formation of constipation, a series of self-poisoning symptoms such as dizziness, nausea, upset and irritability, insomnia, abdominal distension, etc. will occur due to the harmful substances in the intestinal tract not being discharged in time, and severe cases will cause different degrees of inflammatory changes in the colonic mucosa, especia...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P1/10
Inventor 蔡光先朱光葵黄江波张水寒杜赫钟振平
Owner 湖南时代阳光药业股份有限公司
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