Medicine combination for treating coprostasis and preparation method thereof

A technology for treating constipation and a composition, applied in the field of pharmaceutical compositions for treating constipation and their preparation, can solve the problems of intestinal wall cell function and morphological changes, large intestinal epithelium damage, a vicious circle of laxative dependence and the like, and achieves strict compatibility. , targeted and effective effect

Active Publication Date: 2011-05-11
湖南时代阳光药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(3) Lubricating laxatives
It may also cause changes in the function and morphology of intestinal wall cells, thereby causing damage to the large intestinal epithelium
In addition, it may also cause a vicious cycle of dependence on such laxatives

Method used

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  • Medicine combination for treating coprostasis and preparation method thereof
  • Medicine combination for treating coprostasis and preparation method thereof
  • Medicine combination for treating coprostasis and preparation method thereof

Examples

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preparation example Construction

[0020] Preparation of Chinese patent medicine pharmaceutical composition

[0021] In the case that the pharmaceutical composition of the present invention is a Chinese patent medicine form made from the above-mentioned Chinese medicinal materials, it is preferable to use ethanol, water or a mixture of alcohol and water for extraction. In the present invention, aloe vera does not need to be extracted, and can be directly added to the extract of other plant components after being crushed into powder. The extraction can be performed by mixing various medicinal materials other than aloe in the aforementioned ratio and then decocting or refluxing in an appropriate amount of water, ethanol or a mixture of alcohol and water. In this case, the extraction is usually 4 to 14 times the weight, preferably 5 to 12 times the weight, and more preferably 5 to 10 times the weight of the solvent to boil for 1 to 3 hours. In the case of using an aqueous alcohol solution as the extraction solvent,...

Embodiment 1

[0035] 5 parts by weight of aloe vera is crushed into fine powder for later use. 10 parts by weight each of angelica, peach kernel, hemp seed, and cassia seed, add 70% ethanol for reflux extraction twice, the first time add 6 times the amount of ethanol reflux extraction for 2.0 hours; the second time add 5 times the amount of ethanol reflux for 1.5 hours, combine the alcohol Extract the liquid, recover ethanol, concentrate under reduced pressure to an alcohol extract with a relative density of 1.20 (measured at 60°C), and set aside. 24 parts by weight of Rehmannia glutinosa, 24 parts by weight of Scrophulariaceae, 7 parts by weight of Cistanche, 10 parts by weight of Citrus aurantium, decocted twice with water, added 9 times the amount of water for the first time, decocted for 2.0 hours, and extracted with alcohol for the second time Combine the residues, add 7 times the amount of water and decoc for 1.5 hours, combine the decoction, filter, and concentrate the filtrate under ...

Embodiment 2

[0037] 3 parts by weight of aloe vera is crushed into fine powder for later use. 11 parts by weight each of angelica, peach kernel, hemp seed, and cassia seed, add 65% ethanol for reflux extraction twice, the first time add 7 times the amount of ethanol reflux extraction for 2.0 hours; the second time add 5 times the amount of ethanol reflux for 1.5 hours, combine the alcohol Extract the liquid, recover ethanol, concentrate under reduced pressure to an alcohol extract with a relative density of 1.20 (measured at 60°C), and set aside. 18 parts by weight of Rehmannia glutinosa, 25 parts by weight of Scrophulariaceae, 11 parts by weight of Cistanche, 7 parts by weight of Citrus aurantium, decocted twice with water, the first time with 10 times the amount of water, decocted for 2.0 hours, the second time with the alcohol-extracted medicine Combine the residues, add 7 times the amount of water and decoc for 1.5 hours, combine the decoction, filter, and concentrate the filtrate under...

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Abstract

The invention provides a drug combination for the treatment of constipation and a preparation method thereof. The drug combination is prepared by Chinese herbal medicines comprising the following components according to parts by weight: 18 portions to 25 portions of radices rehmanniae, 18 portions to 25 portions of radix scrophularise, 6 portions to 11 portions of angelica, 6 portions to 11 portions of semen persicae, 6 portions to 11 portions of broomrape, 6 portions to 11 portions of fructus cannabis, 6 portions to 11 portions of semen cassiae torae, 6 portions to 11 portions of fructus aurantii immaturus and 3 portions to 6 portions of aloe. The drug combination can further contain proper excipients and other accessories. The drug combination provided by the invention has no vent hard goods with a plurality of side effects, such as rhubarb, thereby forming a more unique characteristic of application so as to realize the functions of nourishing yin and increasing the body fluid as well as loosing the bowel to relieve constipation.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating constipation and a preparation method thereof. Background technique [0002] Constipation is a common clinical disease. According to incomplete statistics, about 3% of young people and 20% of old people suffer from this disease, which seriously affects people's health and life. Its main manifestations are prolonged defecation intervals, dry stools that are difficult to resolve, or difficulty passing out despite the intention of defecation. Constipation is divided into functional and organic constipation, and clinically functional constipation is more common. After the formation of constipation, it may cause dizziness, nausea, irritability, insomnia, abdominal distension and other autotoxic symptoms due to the inability to discharge harmful substances in the intestines in time. In severe cases, it may cause different degrees of inflammatory changes in the colonic mucosa, especially the recta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61P1/10
Inventor 蔡光先朱光葵黄江波张水寒杜赫钟振平
Owner 湖南时代阳光药业股份有限公司
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